MNAT1 - MNAT1 component of CDK activating kinase Gene

Also Known as MAT1; TFB3; CAP35; RNF66

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4331

About MNAT1

Cytogenetic location: 14q23.1 Genomic coordinates (GRCh38): 14:60,734,761-60,969,965 (from NCBI)

This gene has 9 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in fat (RPKM 3.3), prostate (RPKM 3.0) and 25 other tissues.

Summary

The protein encoded by this gene, along with cyclin H and CDK7, forms the CDK-activating kinase (CAK) enzymatic complex. This complex activates several cyclin-associated kinases and can also associate with TFIIH to activate transcription by RNA polymerase II. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

MNAT1 Products (2)

mRNA Protein Name
NM_001177963.2 NP_001171434.1 CDK-activating kinase assembly factor MAT1 isoform 2
NM_002431.4 NP_002422.1 CDK-activating kinase assembly factor MAT1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
8692842 GOA
Biological Process GO Annotation Evidence References Source
involved in regulation of G1/S transition of mitotic cell cycle IDA
IDA: Inferred from direct assay
23622515 GOA
involved in regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9852112 GOA
involved in regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
8692842 GOA
involved in transcription initiation at RNA polymerase II promoter IDA
IDA: Inferred from direct assay
8692841 GOA
Cellular Component GO Annotation Evidence References Source
part of CAK-ERCC2 complex IDA
IDA: Inferred from direct assay
8692841 GOA
part of cyclin-dependent protein kinase holoenzyme complex IDA
IDA: Inferred from direct assay
23622515 GOA
part of transcription factor TFIIH core complex IDA
IDA: Inferred from direct assay
8692841 GOA
part of transcription factor TFIIH holo complex IDA
IDA: Inferred from direct assay
9852112 GOA
part of transcription factor TFIIK complex IDA
IDA: Inferred from direct assay
8692841 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MNAT1 Protein Structure

MAT1

MAT1: CDK-activating kinase assembly factor MAT1 (53 - 252)

  • 0
  • 100
  • 200
  • 309 a.a.
Protein Preferred Names Protein Names

CDK-activating kinase assembly factor MAT1

  • CDK7/cyclin-H assembly factor

MNAT1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MNAT1 P51948 TARDBP Homo sapiens Q13148
Y2H Array
32814053
Intra
MNAT1 P51948 TARDBP Homo sapiens Q13148
Y2H Pooling
32814053
Intra
MNAT1 P51948 TARDBP Homo sapiens Q13148
Validated Y2H
32814053
Intra
MNAT1 P51948 RNF11 Homo sapiens Q9Y3C5
Validated Y2H
32814053
Intra
MNAT1 P51948 RNF11 Homo sapiens Q9Y3C5
Y2H Pooling
32814053
Intra
MNAT1 P51948 RNF11 Homo sapiens Q9Y3C5
Y2H Array
32814053
Intra
MNAT1 P51948 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
26871637
Intra
MNAT1 P51948 GOLGA2 Homo sapiens Q08379
Validated Y2H
26871637
Intra
MNAT1 P51948 GOLGA2 Homo sapiens Q08379
Y2H Array
26871637
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MNAT1 Proteins

Cat. No. Product Name Accession Purity
HY-P75361 CDK7-CCNH-MNAT1 Protein, Human (Active, sf9, His) P50613 (A2-F346)&P51946 (Y2-L323)&P51948 (D2-S309) ≥ 85%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Trichothiodystrophy

  • Ttd

  • Amish Brittle Hair Syndrome

  • Bids Syndrome

  • Brittle Hair-Intellectual Impairment-Decreased Fertility-Short Stature Syndrome

  • Ibids

  • Pibids

  • Trichothiodystrophy Syndromes
Seckel Syndrome 2

  • SCKL2

  • Seckel-Type Dwarfism 2

  • Microcephalic Primordial Dwarfism 2

  • Bird-Headed Dwarfism 2

  • Seckel Syndrome, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08566 MNAT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18829 Mnat1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25320 Mnat1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris MNAT1 VGNC VGNC:43295
Bos taurus MNAT1 VGNC VGNC:31537
Rattus norvegicus MNAT1 RGD RGD:628874
Felis catus MNAT1 VGNC VGNC:68295
Mus musculus MNAT1 MGD MGI:106207
Macaca mulatta MNAT1 VGNC VGNC:74905
Others MNAT1 NCBI