2. Gene
  3. MNAT1 - MNAT1 component of CDK activating kinase Gene

MNAT1 - MNAT1 component of CDK activating kinase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MAT1; TFB3; CAP35; RNF66

Gene ID: 4331 | Gene type: protein coding

About MNAT1

Cytogenetic location: 14q23.1 Genomic coordinates (GRCh38): 14:60,734,761-60,969,965 (from NCBI)

This gene has 9 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in fat (RPKM 3.3), prostate (RPKM 3.0) and 25 other tissues.

Summary

The protein encoded by this gene, along with cyclin H and CDK7, forms the CDK-activating kinase (CAK) enzymatic complex. This complex activates several cyclin-associated kinases and can also associate with TFIIH to activate transcription by RNA polymerase II. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

MNAT1 Products(2)

mRNA Protein Name
NM_001177963.2 NP_001171434.1 CDK-activating kinase assembly factor MAT1 isoform 2
NM_002431.4 NP_002422.1 CDK-activating kinase assembly factor MAT1 isoform 1

MNAT1 Protein Structure

MAT1

MAT1: CDK-activating kinase assembly factor MAT1 (53 - 252)

  • 0
  • 100
  • 200
  • 309 a.a.
Protein Preferred Names Protein Names

CDK-activating kinase assembly factor MAT1

CDK7/cyclin-H assembly factor

Recombinant MNAT1 Proteins

Cat. No. Product Name Accession Purity
HY-P75361 CDK7&CCNH&MNAT1 Protein, Human (sf9, His) P50613 (A2-F346)&P51946 (Y2-L323)&P51948 (D2-S309) ≥95%

Related Diseases

Diseases Alias
Trichothiodystrophy

Ttd

Amish Brittle Hair Syndrome

Bids Syndrome

Brittle Hair-Intellectual Impairment-Decreased Fertility-Short Stature Syndrome

Ibids

Pibids

Trichothiodystrophy Syndromes
Seckel Syndrome 2

SCKL2

Seckel-Type Dwarfism 2

Microcephalic Primordial Dwarfism 2

Bird-Headed Dwarfism 2

Seckel Syndrome, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08566 MNAT1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris MNAT1 VGNC VGNC:43295
Bos taurus MNAT1 VGNC VGNC:31537
Rattus norvegicus MNAT1 RGD RGD:628874
Felis catus MNAT1 VGNC VGNC:68295
Mus musculus MNAT1 MGD MGI:106207
Macaca mulatta MNAT1 VGNC VGNC:74905
Others MNAT1 NCBI