NUDT1 - nudix hydrolase 1 Gene

Also Known as MTH1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4521

About NUDT1

Cytogenetic location: 7p22.3 Genomic coordinates (GRCh38): 7:2,242,226-2,251,145 (from NCBI)

This gene has 9 transcripts (splice variants), 197 orthologues and 3 paralogues. Broad expression in bone marrow (RPKM 17.0), testis (RPKM 13.9) and 24 other tissues.

Summary

Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A rare single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described. [provided by RefSeq, Dec 2018]

NUDT1 Products (10)

mRNA Protein Name
NM_001367553.1 NP_001354482.1 oxidized purine nucleoside triphosphate hydrolase isoform p18
NM_001367554.1 NP_001354483.1 oxidized purine nucleoside triphosphate hydrolase isoform 3
NM_001367555.1 NP_001354484.1 oxidized purine nucleoside triphosphate hydrolase isoform 3
NM_002452.4 NP_002443.3 oxidized purine nucleoside triphosphate hydrolase isoform p18
NM_198948.2 NP_945186.1 oxidized purine nucleoside triphosphate hydrolase isoform p18
NM_198949.2 NP_945187.1 oxidized purine nucleoside triphosphate hydrolase isoform p22
NM_198950.2 NP_945188.1 oxidized purine nucleoside triphosphate hydrolase isoform p18
NM_198952.2 NP_945190.1 oxidized purine nucleoside triphosphate hydrolase isoform p22
NM_198953.1 NP_945191.1 oxidized purine nucleoside triphosphate hydrolase isoform p18
NM_198954.1 NP_945192.1 oxidized purine nucleoside triphosphate hydrolase isoform p22

NUDT1 Protein Structure

NUDIX

NUDIX: NUDIX domain (31 - 152)

  • 0
  • 100
  • 179 a.a.
Protein Preferred Names Protein Names

oxidized purine nucleoside triphosphate hydrolase

  • 2-hydroxy-dATP diphosphatase

NUDT1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NUDT1 P36639 HEL-S-5 Homo sapiens V9HWA0
Y2H Array
25416956
Intra
NUDT1 P36639 HEL-S-5 Homo sapiens V9HWA0
Y2H Prey Pooling
25416956
Intra
NUDT1 P36639 ACY1 Homo sapiens Q03154
Anti Tag CoIP
33961781
Intra
NUDT1 P36639 ACY1 Homo sapiens Q03154
Y2H Array
31515488
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NUDT1 Proteins

Cat. No. Product Name Accession Purity
HY-P74740 MTH1 Protein, Human (His) P36639-4/NP_002443.3 (M1-V156) ≥ 90%, as determined by reducing SDS-PAGE.

NUDT1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82585 MTH1 Antibody (YA2330) WB, IHC-P, ICC/IF, FC, IP Human

Related Diseases

Diseases Alias
Familial Adenomatous Polyposis

  • Adenomatous Polyposis Coli

  • Fap

  • Familial Polyposis Coli

  • Familial Multiple Polyposis Syndrome

  • Adenomatous Polyposis Of The Colon

  • Familial Intestinal Polyposis

  • Fpc

  • Familial Adenomatous Polyposis Of The Colon

  • Familial Multiple Polyposis

  • Familial Polyposis Of The Colon

  • Hereditary Polyposis Coli

  • Polyposis, Adenomatous Intestinal

  • Adenomatous Familial Polyposis

  • Adenomatous Familial Polyposis Syndrome

  • Myh-Associated Polyposis

  • Colorectal Adenomatous Polyposis

  • Adenomatous Polyposis, Familial

  • Mutyh-Associate Polyposis
Gastric Papillary Adenocarcinoma

  • Papillary Adenocarcinoma Of Stomach
Familial Adenomatous Polyposis 2

  • Mutyh-Related Attenuated Familial Adenomatous Polyposis

  • FAP2

  • Colorectal Adenomatous Polyposis, Autosomal Recessive

  • Adenomas, Multiple Colorectal

  • Mutyh-Associated Polyposis

  • Mutyh-Related Attenuated Familial Polyposis Coli

  • Mutyh-Related Attenuated Fap

  • Adenomas, Multiple Colorectal, Autosomal Recessive

  • Mutyh-Related Afap

  • Adenomas Multiple Colorectal Autosomal Recessive

  • Colorectal Adenomatous Polyposis Autosomal Recessive

  • Adenomatous Polyposis, Familial, Type 2
Lung Benign Neoplasm

  • Lung Neoplasms

  • Tumor Of The Lung

  • Lung Tumor
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Lynch Syndrome

  • Hereditary Nonpolyposis Colon Cancer

  • Hereditary Nonpolyposis Colorectal Cancer

  • Hereditary Nonpolyposis Colorectal Carcinoma

  • Hereditary Nonpolyposis Colorectal Neoplasms

  • Familial Nonpolyposis Colon Cancer

  • Hnpcc

  • Coca 1

  • Hereditary Defective Mismatch Repair Syndrome

  • Hereditary Non-Polyposis Colon Cancer

  • Hereditary Non-Polyposis Colon Cancer Syndrome

  • Hereditary Non-Polyposis Colorectal Cancer

  • Hereditary Non-Polyposis Colorectal Cancer Syndrome

  • Hereditary Nonpolyposis Colon Cancer Syndrome

  • Hereditary Nonpolyposis Colorectal Cancer Syndrome

  • Hereditary Nonpolyposis Colorectal Neoplasm

  • Hnpcc - Hereditary Nonpolyposis Colon Cancer

  • Cancer Family Syndrome

  • Familial Nonpolyposis Colorectal Cancer

  • Colon Cancer, Familial Nonpolyposis

  • Colorectal Neoplasms, Hereditary Nonpolyposis

  • Cancer, Colorectal, Nonpolyposis, Hereditary

  • Colorectal Cancer, Hereditary Nonpolyposis, Type 1
Parkinson Disease, Late-Onset

  • Parkinson Disease

  • Parkinson'S Disease

  • PD

  • PARK

  • Parkinson Disease, Susceptibility To

  • Late Onset Parkinson'S Disease

  • Late Onset Parkinson Disease

  • Paralysis Agitans

  • Primary Parkinsonism

  • Idiopathic Parkinson Disease

  • Parkinson'S

  • Parkinson Disease, Late-Onset, Susceptibility To

  • Parkinson Disease, Age Of Onset, Modifier

  • Lewy Body Parkinson Disease

  • Idiopathic Parkinson'S Disease

  • Pd - [Parkinson Disease]

  • Parkinson Disease Nos

  • Parkinson, Nos

  • Primary Parkinson Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-112081 BAY-707 Inhibitor 99.64% Unkown
HY-158062 LC-1-40 99.09% Unkown
HY-187054 NUDT1 ligand-1 Ligand / Unkown
HY-RS09661 NUDT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18535 Nudt1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25017 Nudt1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NUDT1 RGD RGD:621080
Felis catus NUDT1 VGNC VGNC:68589
Macaca mulatta NUDT1 VGNC VGNC:75550
Mus musculus NUDT1 MGD MGI:109280
Canis familiaris NUDT1 VGNC VGNC:44024
Bos taurus NUDT1 VGNC VGNC:32325
Others NUDT1 NCBI