NUDT1 - nudix hydrolase 1 Gene

Homo sapiens

Also known as MTH1

Gene ID: 4521 | Gene type: protein coding

About NUDT1

Cytogenetic location: 7p22.3 Genomic coordinates (GRCh38): 7:2,242,226-2,251,145 (from NCBI)

This gene has 9 transcripts (splice variants), 197 orthologues and 3 paralogues. Broad expression in bone marrow (RPKM 17.0), testis (RPKM 13.9) and 24 other tissues.

Summary

Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an Enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A rare single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described. [provided by RefSeq, Dec 2018]

NUDT1 Products(10)

mRNA	Protein	Name
NM_001367553.1	NP_001354482.1	oxidized purine nucleoside triphosphate hydrolase isoform p18
NM_001367554.1	NP_001354483.1	oxidized purine nucleoside triphosphate hydrolase isoform 3
NM_001367555.1	NP_001354484.1	oxidized purine nucleoside triphosphate hydrolase isoform 3
NM_002452.4	NP_002443.3	oxidized purine nucleoside triphosphate hydrolase isoform p18
NM_198948.2	NP_945186.1	oxidized purine nucleoside triphosphate hydrolase isoform p18
NM_198949.2	NP_945187.1	oxidized purine nucleoside triphosphate hydrolase isoform p22
NM_198950.2	NP_945188.1	oxidized purine nucleoside triphosphate hydrolase isoform p18
NM_198952.2	NP_945190.1	oxidized purine nucleoside triphosphate hydrolase isoform p22
NM_198953.1	NP_945191.1	oxidized purine nucleoside triphosphate hydrolase isoform p18
NM_198954.1	NP_945192.1	oxidized purine nucleoside triphosphate hydrolase isoform p22

NUDT1 Protein Structure

NUDIX

0
100
179 a.a.

Protein Preferred Names

Protein Names

oxidized purine nucleoside triphosphate hydrolase

2-hydroxy-dATP diphosphatase

Recombinant NUDT1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74740	MTH1 Protein, Human (His)	P36639-4/NP_002443.3 (M1-V156)	≥95%

Related Diseases

Diseases

Alias

Familial Adenomatous Polyposis

Adenomatous Polyposis Coli	Fap
Familial Polyposis Coli	Familial Multiple Polyposis Syndrome
Adenomatous Polyposis Of The Colon	Familial Intestinal Polyposis
Fpc	Familial Adenomatous Polyposis Of The Colon
Familial Multiple Polyposis	Familial Polyposis Of The Colon
Hereditary Polyposis Coli	Polyposis, Adenomatous Intestinal
Adenomatous Familial Polyposis	Adenomatous Familial Polyposis Syndrome
Myh-Associated Polyposis	Colorectal Adenomatous Polyposis
Adenomatous Polyposis, Familial	Mutyh-Associate Polyposis

Gastric Papillary Adenocarcinoma

Papillary Adenocarcinoma Of Stomach

Familial Adenomatous Polyposis 2

Mutyh-Related Attenuated Familial Adenomatous Polyposis	FAP2
Colorectal Adenomatous Polyposis, Autosomal Recessive	Adenomas, Multiple Colorectal
Mutyh-Associated Polyposis	Mutyh-Related Attenuated Familial Polyposis Coli
Mutyh-Related Attenuated Fap	Adenomas, Multiple Colorectal, Autosomal Recessive
Mutyh-Related Afap	Adenomas Multiple Colorectal Autosomal Recessive
Colorectal Adenomatous Polyposis Autosomal Recessive	Adenomatous Polyposis, Familial, Type 2

Lung Benign Neoplasm

Lung Neoplasms	Tumor Of The Lung
Lung Tumor

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Lynch Syndrome

Hereditary Nonpolyposis Colon Cancer	Hereditary Nonpolyposis Colorectal Cancer
Hereditary Nonpolyposis Colorectal Carcinoma	Hereditary Nonpolyposis Colorectal Neoplasms
Familial Nonpolyposis Colon Cancer	Hnpcc
Coca 1	Hereditary Defective Mismatch Repair Syndrome
Hereditary Non-Polyposis Colon Cancer	Hereditary Non-Polyposis Colon Cancer Syndrome
Hereditary Non-Polyposis Colorectal Cancer	Hereditary Non-Polyposis Colorectal Cancer Syndrome
Hereditary Nonpolyposis Colon Cancer Syndrome	Hereditary Nonpolyposis Colorectal Cancer Syndrome
Hereditary Nonpolyposis Colorectal Neoplasm	Hnpcc - Hereditary Nonpolyposis Colon Cancer
Cancer Family Syndrome	Familial Nonpolyposis Colorectal Cancer
Colon Cancer, Familial Nonpolyposis	Colorectal Neoplasms, Hereditary Nonpolyposis
Cancer, Colorectal, Nonpolyposis, Hereditary	Colorectal Cancer, Hereditary Nonpolyposis, Type 1

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112081	BAY-707	Inhibitor	99.64%	Unkown
HY-158062	LC-1-40		/	Unkown
HY-RS09661	NUDT1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NUDT1	RGD	RGD:621080
Felis catus	NUDT1	VGNC	VGNC:68589
Macaca mulatta	NUDT1	VGNC	VGNC:75550
Mus musculus	NUDT1	MGD	MGI:109280
Canis familiaris	NUDT1	VGNC	VGNC:44024
Bos taurus	NUDT1	VGNC	VGNC:32325
Others	NUDT1	NCBI

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