MVD - mevalonate diphosphate decarboxylase Gene

Also Known as MPD; MDDase; POROK7; FP17780

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4597

About MVD

Cytogenetic location: 16q24.2 Genomic coordinates (GRCh38): 16:88,651,940-88,663,091 (from NCBI)

This gene has 17 transcripts (splice variants), 199 orthologues and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 12.6), duodenum (RPKM 12.3) and 25 other tissues.

Summary

The enzyme mevalonate pyrophosphate decarboxylase catalyzes the conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate in one of the early steps in Cholesterol biosynthesis. It decarboxylates and dehydrates its substrate while hydrolyzing ATP. [provided by RefSeq, Jul 2008]

MVD Products (1)

mRNA Protein Name
NM_002461.3 NP_002452.1 diphosphomevalonate decarboxylase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables Hsp70 protein binding IPI
IPI: Inferred from physical interaction
12646231 GOA
enables diphosphomevalonate decarboxylase activity IDA
IDA: Inferred from direct assay
11792727 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
8626466 GOA
Biological Process GO Annotation Evidence References Source
involved in isoprenoid biosynthetic process IDA
IDA: Inferred from direct assay
11792727 GOA
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
9270019 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
14972328 GOA
NOT located in peroxisome IDA
IDA: Inferred from direct assay
14972328 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MVD Protein Structure

GHMP_kinases_N

GHMP_kinases_N: GHMP kinases N terminal domain (112 - 156)

  • 0
  • 100
  • 200
  • 300
  • 400 a.a.
Protein Preferred Names Protein Names

diphosphomevalonate decarboxylase

  • mevalonate (diphospho) decarboxylase

Related Diseases

Diseases Alias
Porokeratosis 7, Multiple Types

  • POROK7

  • Porokeratosis 7, Disseminated Superficial Actinic Type
Porokeratosis

  • Disseminated Superficial Actinic Porokeratosis

  • Dsap

  • Porokeratosis Of Mibelli

  • Porokeratosis, Disseminated Superficial Actinic

  • Porokeratosis, Disseminated Superficial Actinic, 1
Linear Porokeratosis

  • Congenital Facial Linear Porokeratosis

  • Porokeratosis, Linear
Scirrhous Adenocarcinoma

  • Adenocarcinoma, Scirrhous

  • Adenocarcinoma With Productive Fibrosis
Punctate Porokeratosis

  • Porokeratosis, Punctate

  • Keratoderma, Palmoplantar, Punctate Type Ii
Ck Syndrome

  • CKS

  • X-Linked Intellectual Disability-Microcephaly-Cortical Malformation-Thin Habitus Syndrome

  • Mental Retardation, X-Linked, With Thin Body Habitus And Cortical Malformation
Zellweger Syndrome

  • Cerebrohepatorenal Syndrome

  • Zellweger Leukodystrophy

  • Zs

  • Congenital Iron Overload

  • Chr

  • Zws

  • Severe Pbd-Zsd

  • Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13561 AZM475271 99.89% Unkown
HY-P1596 Gluten Exorphin C Inhibitor 99.86% Unkown
HY-P3632 [DAla2, DArg6] Dynorphin A, (1-13) (porcine) / Unkown
HY-RS08856 MVD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18453 Mvd Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24934 Mvd Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus MVD VGNC VGNC:31767
Canis familiaris MVD VGNC VGNC:43508
Felis catus MVD VGNC VGNC:68364
Rattus norvegicus MVD RGD RGD:621292
Mus musculus MVD MGD MGI:2179327
Macaca mulatta MVD VGNC VGNC:82192
Others MVD NCBI