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NOTCH1 - notch receptor 1 Gene

Also Known as N1ICD

Species: Canis lupus familiaris (sub-species: familiaris)

Gene Type: protein coding

Gene ID: 480676

About NOTCH1

Primary_assembly 9: 49,851,628-49,894,186 forward strand.ROS_Cfam_1.0:CM025108.1

This gene has 3 transcripts (splice variants), 273 orthologues and 3 paralogues.

NOTCH1 Products (2)

mRNA	Protein	Name
XM_038677974.1	XP_038533902.1	neurogenic locus notch homolog protein 1
XM_038677974.1	XP_038533902.1	neurogenic locus notch homolog protein 1

NOTCH1 Protein Structure

EGF_CA

Notch

NOD

NODP

JMTM_Notch1

ANKYR

ANK

ANKYR

Ank_2

ANK

0
400
800
1200
1600
2000
2400
2574 a.a.

Protein Preferred Names	Protein Names
neurogenic locus notch homolog protein 1	Notch homolog 1, translocation-associated notch 1

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (4)

Cat. No.	Product Name	Purity	Rare Diseases
HY-10585	Valproic acid	99.89%	Unkown
HY-10585A	Valproic acid sodium	99.65%	Unkown
HY-10585AR	Valproic acid sodium (Standard)	98.92%	Unkown
HY-10585B	Valproic acid sodium (2:1)	/	Unkown

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-N0711	Carvacrol		99.98%	Phase 3
HY-15670	BMS-906024	Inhibitor	99.91%	Phase 1
HY-12860	BMS-986115	Inhibitor	99.90%	Phase 1

Bioactive MoleculesInhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99258	Brontictuzumab	Inhibitor	95.00%	Phase 1
HY-P991423	MEDI0639	Inhibitor	98.78%	Phase 1

Pre-clinical Phase

Bioactive Molecules (40)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13027	DAPT		99.97%	Unkown
HY-N0133	Tangeretin		99.36%	Unkown
HY-134978A	(+)SHIN2	Inhibitor	99.30%	Unkown
HY-N0232	Psoralidin		99.90%	Unkown
HY-124284	Hexamethylene bisacetamide		99.56%	Unkown
HY-N5112B	β,β-Dimethylacrylshikonin		99.30%	Unkown
HY-14174	MRK-560	Inhibitor	99.92%	Unkown
HY-10585R	Valproic acid (Standard)		99.97%	Unkown
HY-164404	NADI-351	Inhibitor	99.83%	Unkown
HY-10585S2	Valproic acid-d15		99.80%	Unkown
HY-N1510	Kaempferol 3-O-gentiobioside	Inhibitor	99.88%	Unkown
HY-10585S1	Valproic acid-d6		99.83%	Unkown
HY-144899	ASR-490	Inhibitor	99.20%	Unkown
HY-10585S	Valproic acid-d4		98.0%	Unkown
HY-12465	Z-Ile-Leu-aldehyde		97.0%	Unkown
HY-N11709	Theasaponin E1		98.68%	Unkown
HY-N2896	Arjunolic acid		98.83%	Unkown
HY-10585S4	Valproic acid-d4-1		99.5%	Unkown
HY-P1985	Notch 1		95.39%	Unkown
HY-10585AS1	Valproic acid-d14 sodium		96.73%	Unkown
HY-164466	CAD204520	Inhibitor	99.22%	Unkown
HY-164466A	CAD204520 dihydrochloride	Inhibitor	99.26%	Unkown
HY-P1985A	Notch 1 TFA		/	Unkown
HY-RS09445	NOTCH1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-141876	PRT543		/	Unkown
HY-183626	PAI-1-IN-1		/	Unkown
HY-10585AS	Valproic acid-d7 sodium		/	Unkown
HY-103539	3,5-Bis(4-nitrophenoxy)benzoic acid	Inhibitor	98.50%	Unkown
HY-10585AG	Valproic acid sodium (GMP)		/	Unkown
HY-10585S3	Valproic acid-d4 sodium		/	Unkown
HY-118900	CP-654577		/	Unkown
HY-120372	BMS-871	Inhibitor	/	Unkown
HY-181975	ATOX1-IN-1	Inhibitor	/	Unkown
HY-E70178	Protein O-Glucosyltransferase 1		/	Unkown
HY-N9790	Procyanidin B2 3,3'-di-O-gallate	Inhibitor	/	Unkown
HY-RS09446	Notch1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09447	Notch1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W794759	Valproic acid magnesium		/	Unkown
HY-N12768	Rhodojaponin VI	Inhibitor	/	Unkown
HY-W714200	Neburon		/	Unkown

Bioactive MoleculesInhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991328	MAb604.107	Inhibitor	/	Unkown
HY-P992275	Anti-Nicastrin Antibody (A5226A)	Inhibitor	/	Unkown
HY-P990476	Anti-NOTCH1 Antibody	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	NOTCH1	NCBI	NCBI:4851