NID1 - nidogen 1 Gene

Also Known as NID

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4811

About NID1

Cytogenetic location: 1q42.3 Genomic coordinates (GRCh38): 1:235,975,830-236,065,090 (from NCBI)

This gene has 2 transcripts (splice variants), 264 orthologues, 14 paralogues and is associated with 1 phenotype. Broad expression in placenta (RPKM 93.1), gall bladder (RPKM 48.2) and 20 other tissues.

Summary

This gene encodes a member of the nidogen family of basement membrane glycoproteins. The protein interacts with several Other components of basement membranes, and may play a role in cell interactions with the extracellular matrix. [provided by RefSeq, Jul 2008]

NID1 Products (1)

mRNA	Protein	Name
NM_002508.3	NP_002499.2	nidogen-1 precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Referencias	Source
enables collagen binding	IDA IDA: Inferred from direct assay	22952693	GOA
enables laminin binding	IDA IDA: Inferred from direct assay	22952693	GOA
enables proteoglycan binding	IPI IPI: Inferred from physical interaction	22952693	GOA

Cellular Component GO Annotation	Evidence	Referencias	Source
located in basement membrane	IDA IDA: Inferred from direct assay	22952693	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NID1 Protein Structure

NIDO

G2F

EGF_3

EGF_CA

cEGF

EGF_3

Thyroglobulin_1

Ldl_recept_b

FXa_inhibition

0
200
400
600
800
1000
1247 a.a.

Protein Preferred Names	Protein Names
nidogen-1	NID-1

NID1 Antibodies

Referencia número	Nombre del producto	Aplicación	Reactivity
HY-P83142	Entactin Antibody (YA2887)	WB, IHC-P	Human
HY-P83142A	Entactin Antibody (YA2887)(PBS only)	WB, IHC-P	Human

Related Diseases

Diseases	Alias
Isolated Dandy-Walker Malformation Without Hydrocephalus
Focal Epilepsy	Partial Epilepsy Epilepsies, Partial Localisation-Related Epilepsy
Hydrocephalus	Hydrocephalus, Nonsyndromic, Autosomal Recessive Hydrocephalus, X-Linked Hydrocephalus Adverse Event Hydrocephaly Nos
Pierson Syndrome	Microcoria-Congenital Nephrotic Syndrome Microcoria-Congenital Nephrosis Syndrome PIERS Microcoria - Congenital Nephrosis Microcoria - Congenital Nephrotic Syndrome PIERSS
Glomerulonephritis	Bright'S Disease
Adenoid Cystic Carcinoma	Adenocystic Carcinoma Cribriform Carcinoma Cylindroma Carcinoma Adenoid Cystic Carcinoma, Adenoid Cystic Adenoid Cystic Carcinoma Of Salivary Gland Eccrine Dermal Cylindroma Carcinoma, Cribriform
Nephrotic Syndrome, Type 5, With Or Without Ocular Abnormalities	NPHS5 Nephrotic Syndrome Type 5 Nephrotic Syndrome Type 5, With Or Without Ocular Abnormalities Nephrotic Syndrome 5 With Or Without Ocular Abnormalities Nephrotic Syndrome, Type 5, With/Without Ocular Abnormalities
Deafness, Autosomal Dominant 56	DFNA56 Autosomal Dominant Nonsyndromic Deafness 56 Autosomal Dominant Deafness 56 Deafness, Autosomal Dominant, 56 Deafness, Autosomal Dominant, Type 56
Corneal Abscess
X-Linked Alport Syndrome	Nephropathy And Deafness, X-Linked
Schwartz-Jampel Syndrome, Type 1	Schwartz-Jampel Syndrome SJS1 Schwartz-Jampel-Aberfeld Syndrome Sjs Chondrodystrophic Myotonia Schwartz-Jampel Syndrome Type 1 Sja Syndrome Aberfeld Syndrome Burton Skeletal Dysplasia Burton Syndrome Catel-Hempel Syndrome Myotonic Chondrodystrophy Myotonic Myopathy, Dwarfism, Chondrodystrophy, Ocular And Facial Anomalies Osteochondromuscular Dystrophy Myotonic Myopathy, Dwarfism, Chondrodystrophy, And Ocular And Facial Abnormalities Schwartz-Jampel Syndrome 1 Dysostosis Enchondralis Metaepiphysaria, Catel-Hempel Type Catel-Hempel Type Dysostosis Enchondralis Metaepiphysaria Schwartz Jampel Syndrome Myotonic Myopathy Dwarfism Chondrodystrophy And Ocular And Facial Abnormalities Schwartz Jampel Aberfeld Syndrome Congenital Blepharophimosis, Myopia, Myopathy Syndrome Kniest-Like Dysplasia With Pursed Lips And Ectopia Lentis
Deafness, Autosomal Recessive 21	DFNB21 Autosomal Recessive Nonsyndromic Deafness 21 Autosomal Recessive Deafness 21 Deafness, Autosomal Recessive, 21 Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 21 Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 21 Deafness, Autosomal Recessive, Type 21
Alport Syndrome	Hereditary Nephritis Alport Syndrome, X-Linked Hemorrhagic Hereditary Nephritis Congenital Hereditary Hematuria Hemorrhagic Familial Nephritis Familial Nephritis Thin Basement Membrane Disease Thin Basement Membrane Nephropathy Hematuria-Nephropathy-Deafness Syndrome Hematuric Hereditary Nephritis Hereditary Familial Congenital Hemorrhagic Nephritis Hereditary Hematuria Syndrome Hereditary Interstitial Pyelonephritis Alport Deafness-Nephropathy Alport Hearing Loss-Nephropathy Alports Syndrome Nephritis, Hereditary
Macular Degeneration, Age-Related, 1	Macular Degeneration Age-Related Macular Degeneration Macular Degeneration, Age-Related Age Related Macular Degeneration Age Related Macular Degeneration 1 ARMD1 Senile Macular Degeneration Maculopathy, Age-Related, 1 Macular Degeneration, Age-Related, Reduced Risk Of Age Related Maculopathy 1 Age Related Maculopathies Age Related Maculopathy Senile Macular Retinal Degeneration Macular Degeneration Of Retina Age-Related Maculopathy Amd Armd Age-Related Maculopathy, Susceptibility To Maculopathy Age-Related Macular Degeneration, Age-Related, 1, Susceptibility To Maculopathy, Age-Related Macular Degeneration, Age-Related, Type 1 Macular Degeneration, Age-Related, 2
Porencephaly
Goodpasture Syndrome	Anti-Glomerular Basement Membrane Disease Anti-Gbm Disease Pulmonary Renal Syndrome Anti-Glomerular Basement Membrane Antibody Disease Glomerulonephritis - Pulmonary Hemorrhage Rapidly Progressive Glomerulonephritis With Pulmonary Hemorrhage Anti-Gbm Syndrome Goodpasture'S Syndrome Anti-Basement Membrane Glomerulonephritis
Junctional Epidermolysis Bullosa	Epidermolysis Bullosa, Junctional Jeb Epidermolysis Bullosa Atrophicans Congenital Junctional Epidermolysis Bullosa Epidermolysis Bullosa Junctional Junctional Eb - [Epidermolysis Bullosa] Jeb - [Junctional Epidermolysis Bullosa] Lucidolytic Epidermolysis Bullosa
Chromosome 2q35 Duplication Syndrome	Syndactyly Syndactyly Type 1 Sdty1 Zygodactyly Syndactyly, Type I Sd1 Syndactyly, Type 1, With Or Without Craniosynostosis Symphalangism Non-Syndromic Syndactyly Symphalangy Webbing Of Digits Syndactyly, Type 1
Muscular Dystrophy, Congenital Merosin-Deficient, 1a	MDC1A Lama2-Related Muscular Dystrophy Atrophie Blanche Muscular Dystrophy, Congenital Merosin-Deficient Congenital Merosin-Deficient Muscular Dystrophy 1a Merosin-Negative Congenital Muscular Dystrophy Muscular Dystrophy White Matter Spongiosis Merosin Deficient Congenital Muscular Dystrophy Muscular Dystrophy Congenital, Merosin Negative Muscular Dystrophy, Congenital, Merosin Deficient Or Partially Deficient Cmd1a Congenital Muscular Dystrophy Due To Laminin Alpha2 Deficiency Congenital Muscular Dystrophy Type 1a Laminin Alpha-2 Deficiency Merosin-Deficient Congenital Muscular Dystrophy Muscular Dystrophy, Congenital, Merosin-Deficient Lama2 Md Laminin Alpha 2 Deficiency Laminin Alpha-2 Deficient Muscular Dystrophy Merosin-Deficient Muscular Dystrophy Muscular Dystrophy Due To Lama2 Deficiency Merosin-Deficient Congenital Muscular Dystrophy 1a Cardiomyopathy, Familial Idiopathic
Autosomal Recessive Alport Syndrome	Alport Syndrome, Recessive Type Alport Syndrome, Autosomal Recessive Alport Syndrome Autosomal Recessive Alport Syndrome Recessive Type Nephropathy And Deafness
Autosomal Dominant Alport Syndrome	Alport Syndrome, Autosomal Dominant Alport Syndrome Dominant Type Renal Failure And Sensorineural Hearing Loss Alport Syndrome, Dominant Type
Hematuria, Benign Familial	Benign Familial Hematuria BFH Thin Membrane Nephropathy Tmn Thin Basement Membrane Nephropathy Thin-Basement-Membrane Nephropathy Hematuria, Familial Benign Hematuria Benign Familial Hematuria, Benign, Familial Thin Basement Membrane Disease
Walker-Warburg Syndrome	Hard Syndrome Walker-Warburg Congenital Muscular Dystrophy Cerebroocular Dysplasia-Muscular Dystrophy Syndrome Cod-Md Syndrome Chemke Syndrome Hydrocephalus, Agyria And Retinal Dysplasia Cerebroocular Dysgenesis Cerebroocular Dysplasia Muscular Dystrophy Syndrome Hard +/- E Syndrome Pagon Syndrome Warburg Syndrome Hydrocephalus, Agyria, And Retinal Dysplasia Mddga Muscular Dystrophy-Dystroglycanopathy , Type A Muscular Dystrophy-Dystroglycanopathy [With Brain And Eye Anomalies], Type A Hydrocephalus-Agyria-Retinal Dysplasia Syndrome Wws Dystrophy, Muscular, Dystroglycanopathy, Type A

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-RS09294	NID1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18778	Nid1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25267	Nid1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NID1	RGD	RGD:3178
Bos taurus	NID1	VGNC	VGNC:55991
Mus musculus	NID1	MGD	MGI:97342
Macaca mulatta	NID1	VGNC	VGNC:75349
Canis familiaris	NID1	VGNC	VGNC:43807
Felis catus	NID1	VGNC	VGNC:68495
Others	NID1	NCBI