ORM1 - orosomucoid 1 Gene

Also Known as ORM; AGP1; AGP-A; HEL-S-153w

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5004

About ORM1

Cytogenetic location: 9q32 Genomic coordinates (GRCh38): 9:114,323,098-114,326,479 (from NCBI)

This gene has 2 transcripts (splice variants), 137 orthologues and 1 paralogue. Restricted expression toward liver (RPKM 4993.2).

Summary

This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression. [provided by RefSeq, Jul 2008]

ORM1 Products (1)

mRNA Protein Name
NM_000607.4 NP_000598.2 alpha-1-acid glycoprotein 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16272158 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of interleukin-6 production IDA
IDA: Inferred from direct assay
23973664 GOA
involved in negative regulation of tumor necrosis factor production IDA
IDA: Inferred from direct assay
23973664 GOA
involved in positive regulation of interleukin-1 beta production IDA
IDA: Inferred from direct assay
8774350 GOA
involved in positive regulation of interleukin-1 production IDA
IDA: Inferred from direct assay
8774350 GOA
involved in positive regulation of tumor necrosis factor production IDA
IDA: Inferred from direct assay
8774350 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
8774350 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ORM1 Protein Structure

Lipocalin

Lipocalin: Lipocalin / cytosolic fatty-acid binding protein family (40 - 179)

  • 0
  • 100
  • 201 a.a.
Protein Preferred Names Protein Names

alpha-1-acid glycoprotein 1

  • AGP 1

ORM1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ORM1 P02763 ORM2 Homo sapiens P19652
Anti Tag CoIP
33961781
Intra
ORM1 P02763 ORM2 Homo sapiens P19652
Anti Tag CoIP
28514442
Intra
ORM1 P02763 SERPINE1 Homo sapiens P05121
FACS
16272158
Intra
ORM1 P02763 SERPINE1 Homo sapiens P05121
Confocal
16272158
Cross: Cross-species interaction Intra: Intraspecies interaction

ORM1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P86781 Alpha 1 Acid Glycoprotein Antibody (YA6474) WB, IHC-P Human

Related Diseases

Diseases Alias
Appendicitis

  • Acute Appendicitis

  • Acute Appendicitis With Generalized Peritonitis

  • Acute Appendicitis Nos

  • Acute Appendicitis With Peritoneal Abscess

  • Appendiceal Inflammation

  • Appendicitis, Unqualified

  • Acute Appendix Inflammation

  • Acute Appendicitis With Diffuse Peritonitis Following Rupture Or Perforation

  • Acute Appendicitis With Free Peritonitis

  • Acute Appendicitis With Free Perforation To The Abdominal Cavity

  • Perforated Appendix With Generalised Peritonitis

  • Appendicitis With Perforation And Free Pus In The Peritoneal Cavity

  • Perforated Appendix With Localised Peritonitis

  • Acute Appendicitis With Contained Perforation To A Localised Abscess

  • Acute Appendicitis With Localised Peritonitis With Rupture Or Perforation

  • Acute Appendicitis With Localised Peritonitis Without Rupture Or Perforation

  • Acute Appendicitis With Perforation And Contained Peritonitis Into An Abscess

  • Appendicitis With Abscess

  • Appendicitis With Peritoneal Abscess

  • Ruptured Appendix Nos

  • Acute Appendicitis With No Perforation Or Abscess And No Visible Pus

  • Acute Appendicitis With No Specification If Perforated Or Not

  • Acute Appendicitis With Phlegmone
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09831 ORM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18779 Orm1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25268 Orm1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ORM1 RGD RGD:67390