PAFAH2 - platelet activating factor acetylhydrolase 2 Gene

This gene encodes platelet-activating factor acetylhydrolase isoform 2, a single-subunit intracellular enzyme that catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). However, this Lipase exhibits a broader substrate specificity than simply platelet activating factor. Two Other isoforms of intracellular platelet-activating factor acetylhydrolase exist, and both are multi-subunit Enzymes. Additionally, there is a single-subunit serum isoform of this enzyme. [provided by RefSeq, Jul 2008]