Ero1a - endoplasmic reticulum oxidoreductase 1 alpha Gene

Also Known as Ero1l; ERO1-L

Species: Mus musculus

Gene Type: protein coding
Gene ID: 50527

Summary

This gene encodes a member of the endoplasmic reticulum oxidoreductin family. The encoded protein is localized to the endoplasmic reticulum and promotes the formation of disulfide bonds by oxidizing protein disulfide isomerase. This gene may play a role in endoplasmic reticulum stress-induced Apoptosis and the cellular response to hypoxia. [provided by RefSeq, Feb 2011]

Ero1a Products (1)

mRNA Protein Name
NM_015774.3 NP_056589.1 ERO1-like protein alpha precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables oxidoreductase activity IDA
IDA: Inferred from direct assay
15601821 MGI
enables protein-disulfide reductase activity IDA
IDA: Inferred from direct assay
20308425 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within L-ascorbic acid metabolic process IMP
IMP: Inferred from mutant phenotype
28106121 MGI
acts upstream of or within brown fat cell differentiation IDA
IDA: Inferred from direct assay
18492766 MGI
acts upstream of or within cell redox homeostasis IGI
IGI: Inferred from genetic interaction
23589496 MGI
acts upstream of or within collagen fibril organization IMP
IMP: Inferred from mutant phenotype
28106121 MGI
acts upstream of or within endoplasmic reticulum unfolded protein response IDA
IDA: Inferred from direct assay
15601821 MGI
acts upstream of or within extracellular matrix organization IGI
IGI: Inferred from genetic interaction
22981861 MGI
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
IMP: Inferred from mutant phenotype
19752026 MGI
acts upstream of or within peptidyl-proline hydroxylation to 4-hydroxy-L-proline IGI
IGI: Inferred from genetic interaction
22981861 MGI
acts upstream of or within protein folding IDA
IDA: Inferred from direct assay
15601821 MGI
acts upstream of or within protein maturation by protein folding IGI
IGI: Inferred from genetic interaction
22981861 MGI
involved in release of sequestered calcium ion into cytosol IMP
IMP: Inferred from mutant phenotype
19752026 MGI
involved in response to endoplasmic reticulum stress IDA
IDA: Inferred from direct assay
19752026 MGI
acts upstream of or within response to oxidative stress IDA
IDA: Inferred from direct assay
25452428 MGI
acts upstream of or within skeletal muscle tissue development IMP
IMP: Inferred from mutant phenotype
28106121 MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
28106121 MGI
Cellular Component GO Annotation Evidence References Source
is active in endoplasmic reticulum IMP
IMP: Inferred from mutant phenotype
28106121 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ERO1-like protein alpha

  • ERO1-L-alpha

  • ERO1-like

  • endoplasmic oxidoreductin-1-like protein

  • endoplasmic reticulum oxidation 1

  • endoplasmic reticulum oxidoreductase alpha

  • endoplasmic reticulum oxidoreductin-1-like protein

  • oxidoreductin-1-L-alpha

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-141462 2',4-Dihydroxychalcone 96.59% Unkown
HY-RS04511 ERO1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28082 Ero1a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21564 Ero1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ero1a NCBI NCBI:30001