ERO1A - endoplasmic reticulum oxidoreductase 1 alpha Gene

Also Known as ERO1L; ERO1-L; ERO1LA; Ero1alpha; ERO1-alpha; ERO1-L-alpha

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 30001

About ERO1A

Cytogenetic location: 14q22.1 Genomic coordinates (GRCh38): 14:52,639,915-52,695,558 (from NCBI)

This gene has 11 transcripts (splice variants), 197 orthologues and 1 paralogue. Broad expression in esophagus (RPKM 69.5), placenta (RPKM 19.1) and 21 other tissues.

Summary

Enables oxidoreductase activity. Involved in chaperone cofactor-dependent protein refolding. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

ERO1A Products (14)

mRNA Protein Name
NM_001382464.1 NP_001369393.1 ERO1-like protein alpha isoform 1 precursor
NM_001382465.1 NP_001369394.1 ERO1-like protein alpha isoform 3 precursor
NM_001382466.1 NP_001369395.1 ERO1-like protein alpha isoform 4 precursor
NM_001382467.1 NP_001369396.1 ERO1-like protein alpha isoform 5 precursor
NM_001382468.1 NP_001369397.1 ERO1-like protein alpha isoform 6 precursor
NM_001382469.1 NP_001369398.1 ERO1-like protein alpha isoform 7 precursor
NM_001382470.1 NP_001369399.1 ERO1-like protein alpha isoform 8 precursor
NM_001382471.1 NP_001369400.1 ERO1-like protein alpha isoform 9 precursor
NM_001382472.1 NP_001369401.1 ERO1-like protein alpha isoform 10 precursor
NM_001382473.1 NP_001369402.1 ERO1-like protein alpha isoform 11 precursor
NM_001382474.1 NP_001369403.1 ERO1-like protein alpha isoform 12 precursor
NM_001382475.1 NP_001369404.1 ERO1-like protein alpha isoform 13 precursor
NM_001382476.1 NP_001369405.1 ERO1-like protein alpha isoform 14 precursor
NM_014584.3 NP_055399.1 ERO1-like protein alpha isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables oxidoreductase activity IDA
IDA: Inferred from direct assay
11707400 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17170699 GOA
Biological Process GO Annotation Evidence References Source
involved in cell redox homeostasis IMP
IMP: Inferred from mutant phenotype
29858230 GOA
involved in chaperone cofactor-dependent protein refolding IDA
IDA: Inferred from direct assay
11707400 GOA
involved in protein folding IMP
IMP: Inferred from mutant phenotype
29858230 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi lumen IDA
IDA: Inferred from direct assay
29858230 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
10671517 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
29858230 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ERO1A Protein Structure

ERO1

ERO1: Endoplasmic Reticulum Oxidoreductin 1 (ERO1) (60 - 457)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 468 a.a.
Protein Preferred Names Protein Names

ERO1-like protein alpha

  • endoplasmic oxidoreductin-1-like protein

ERO1A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ERO1A Q96HE7 LHX4 Homo sapiens Q969G2
Y2H Prey Pooling
32296183
Intra
ERO1A Q96HE7 LHX4 Homo sapiens Q969G2
Y2H Array
32296183
Intra
ERO1A Q96HE7 P4HB Homo sapiens P07237
Anti Tag CoIP
20802462
Intra
ERO1A Q96HE7 APPBP2 Homo sapiens Q92624
Y2H Prey Pooling
25416956
Intra
ERO1A Q96HE7 PDIA3 Homo sapiens P30101
Anti Tag CoIP
20802462
Intra
ERO1A Q96HE7 PDIA3 Homo sapiens P30101
Anti Tag CoIP
17170699
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ERO1A Proteins

Cat. No. Product Name Accession Purity
HY-P70893 ERO1L Protein, Human (HEK293, His) Q96HE7 (E24-H468) ≥ 95%, as determined by reducing SDS-PAGE.

ERO1A Antibodies

Cat. No. Product Name Application Reactivity
HY-P86865 ERO1L Antibody (YA6558) WB, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Cholera

  • Vibrio Cholerae Infection

  • Cholera - Vibrio Cholerae

  • Cholera Due To Vibrio Cholerae

  • Vibrio Cholerae

  • Cholera Syndrome

  • Asiatic Cholera

  • Epidemic Cholera
Hypoascorbemia

  • Scurvy

  • Ascorbic Acid Deficiency

  • Vitamin C Deficiency

  • Vitamin C, Inability To Synthesize

  • Deficiency Of Vitamin C

  • Scorbutus

  • Vitamin C
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-141462 2',4-Dihydroxychalcone 96.59% Unkown
HY-RS04511 ERO1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28082 Ero1a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21564 Ero1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ERO1A VGNC VGNC:72266
Mus musculus ERO1A MGD MGI:1354385
Bos taurus ERO1A VGNC VGNC:28594
Canis familiaris ERO1A VGNC VGNC:40466
Rattus norvegicus ERO1A RGD RGD:621713
Felis catus ERO1A VGNC VGNC:61954
Others ERO1A NCBI