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Ptk2b - protein tyrosine kinase 2 beta Gene

Also Known as CAKB; Pyk2; CAKbeta; CAK beta

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 50646

Summary

Enables 3-phosphoinositide-dependent protein kinase binding activity; calmodulin-dependent protein kinase activity; and ubiquitin protein Ligase binding activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of cell communication; and positive regulation of cellular biosynthetic process. Located in several cellular components, including dendrite; focal adhesion; and postsynaptic density. Part of NMDA selective glutamate receptor complex. Is active in glutamatergic synapse and postsynapse. Used to study brain ischemia; diabetic angiopathy; and nephritis. Biomarker of anti-basement membrane glomerulonephritis; hypertension; and status epilepticus. Human ortholog(s) of this gene implicated in breast Cancer and hypertension. Orthologous to human PTK2B (protein tyrosine kinase 2 beta). [provided by Alliance of Genome Resources, Apr 2022]

Ptk2b Products (1)

mRNA	Protein	Name
NM_017318.3	NP_059014.2	protein-tyrosine kinase 2-beta

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 3-phosphoinositide-dependent protein kinase binding	IDA IDA: Inferred from direct assay	14585963	RGD
enables calcium/calmodulin-dependent protein kinase activity	IDA IDA: Inferred from direct assay	17188509	RGD
enables enzyme binding	IPI IPI: Inferred from physical interaction	16945503	RGD
enables glutamate receptor binding	IPI IPI: Inferred from physical interaction	11239437	RGD
enables neurotransmitter receptor regulator activity	IMP IMP: Inferred from mutant phenotype	11239437	RGD
enables non-membrane spanning protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	11239437	RGD
enables non-membrane spanning protein tyrosine kinase activity	IMP IMP: Inferred from mutant phenotype	15814199	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	8849729	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	10708762	RGD
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	16945503	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in MAPK cascade	IMP IMP: Inferred from mutant phenotype	15096502	RGD
involved in actin filament organization	IMP IMP: Inferred from mutant phenotype	17127746	RGD
involved in activation of GTPase activity	IMP IMP: Inferred from mutant phenotype	15158121	RGD
involved in activation of Janus kinase activity	IMP IMP: Inferred from mutant phenotype	11818507	RGD
involved in angiogenesis	IMP IMP: Inferred from mutant phenotype	11739395	RGD
involved in blood vessel endothelial cell migration	IMP IMP: Inferred from mutant phenotype	11739395	RGD
involved in cell adhesion	IMP IMP: Inferred from mutant phenotype	11739395	RGD
involved in cell differentiation	IEP IEP: Inferred from expression pattern	10964954	RGD
involved in cellular defense response	IMP IMP: Inferred from mutant phenotype	17188509	RGD
involved in epidermal growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	16945503	RGD
involved in focal adhesion assembly	IMP IMP: Inferred from mutant phenotype	14585963	RGD
involved in glial cell proliferation	IEP IEP: Inferred from expression pattern	11389173	RGD
involved in ionotropic glutamate receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	15814199	RGD
involved in long-term synaptic depression	IMP IMP: Inferred from mutant phenotype	20826662	RGD
involved in long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	11239437	RGD
involved in negative regulation of muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	12668584	RGD
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	17188509	RGD
involved in negative regulation of ossification	IMP IMP: Inferred from mutant phenotype	17537919	RGD
involved in neuron projection development	IMP IMP: Inferred from mutant phenotype	10980697	RGD
involved in oocyte maturation	IMP IMP: Inferred from mutant phenotype	17127746	RGD
involved in peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	14585963	RGD
involved in positive regulation of DNA biosynthetic process	IMP IMP: Inferred from mutant phenotype	21451101	RGD
involved in positive regulation of JUN kinase activity	IMP IMP: Inferred from mutant phenotype	15226266	RGD
involved in positive regulation of cell growth	IMP IMP: Inferred from mutant phenotype	15158121	RGD
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	16945503	RGD
involved in positive regulation of cell population proliferation	IEP IEP: Inferred from expression pattern	11352836	RGD
involved in positive regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	11739373	RGD
involved in positive regulation of excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	11239437	RGD
involved in positive regulation of nitric oxide biosynthetic process	IMP IMP: Inferred from mutant phenotype	21926342	RGD
involved in positive regulation of nitric-oxide synthase activity	IMP IMP: Inferred from mutant phenotype	21926342	RGD
involved in positive regulation of protein metabolic process	IMP IMP: Inferred from mutant phenotype	21451101	RGD
involved in positive regulation of reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	15158121	RGD
involved in positive regulation of synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	11239437	RGD
involved in positive regulation of translation	IMP IMP: Inferred from mutant phenotype	12890645	RGD
involved in postsynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	20071509	RGD
involved in postsynaptic modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	20071509	RGD
involved in response to cAMP	IEP IEP: Inferred from expression pattern	16120467	RGD
involved in response to calcium ion	IEP IEP: Inferred from expression pattern	16120467	RGD
involved in response to cation stress	IDA IDA: Inferred from direct assay	17188509	RGD
involved in response to cocaine	IEP IEP: Inferred from expression pattern	12117546	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	12684223	RGD
involved in response to glucose	IEP IEP: Inferred from expression pattern	11463795	RGD
involved in response to hormone	IEP IEP: Inferred from expression pattern	16713446	RGD
involved in response to hydrogen peroxide	IPI IPI: Inferred from physical interaction	16187300	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	11781137	RGD
involved in response to immobilization stress	IEP IEP: Inferred from expression pattern	12946883	RGD
involved in response to ischemia	IMP IMP: Inferred from mutant phenotype	15814199	RGD
involved in response to mechanical stimulus	IEP IEP: Inferred from expression pattern	15096502	RGD
involved in response to reactive oxygen species	IEP IEP: Inferred from expression pattern	15203192	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	11139427	RGD
involved in stress fiber assembly	IMP IMP: Inferred from mutant phenotype	11739395	RGD

Cellular Component GO Annotation	Evidence	References	Source
part of NMDA selective glutamate receptor complex	IDA IDA: Inferred from direct assay	11239437	RGD
part of NMDA selective glutamate receptor complex	IMP IMP: Inferred from mutant phenotype	15814199	RGD
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	20071509	RGD
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	20071509	RGD
located in apical dendrite	IDA IDA: Inferred from direct assay	10583467	RGD
located in axon	IDA IDA: Inferred from direct assay	15128873	RGD
located in cell body	IDA IDA: Inferred from direct assay	10022914	RGD
located in cell cortex	IDA IDA: Inferred from direct assay	17127746	RGD
located in cell projection	IDA IDA: Inferred from direct assay	10022914	RGD
located in dendrite	IDA IDA: Inferred from direct assay	10583467	RGD
located in focal adhesion	IDA IDA: Inferred from direct assay	17157995	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	22973009	RGD
located in growth cone	IDA IDA: Inferred from direct assay	10583467	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	10583467	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	16945503	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	22973009	RGD
located in postsynaptic density	IDA IDA: Inferred from direct assay	11239437	RGD
is active in postsynaptic density, intracellular component	IDA IDA: Inferred from direct assay	20071509	RGD
is active in postsynaptic density, intracellular component	IMP IMP: Inferred from mutant phenotype	20071509	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
protein-tyrosine kinase 2-beta	CADTK CAK-beta FADK 2 PTK2 protein tyrosine kinase 2 beta PTK2B protein tyrosine kinase 2 beta calcium-dependent tyrosine kinase calcium-regulated non-receptor proline-rich tyrosine kinase cell adhesion kinase beta focal adhesion kinase 2 proline

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148061	DB1113		99.86%	Unkown
HY-148063	DB0614		99.92%	Unkown
HY-148066	DB0662	Degrader	99.66%	Unkown
HY-RS26981	Ptk2b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11402	PTK2B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20473	Ptk2b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ptk2b	NCBI	NCBI:2185