REG3A - regenerating family member 3 alpha Gene

Also Known as HIP; PAP; PAP1; REG3; INGAP; PAP-H; PBCGF; HIP/PAP; REG-III

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5068

About REG3A

Cytogenetic location: 2p12 Genomic coordinates (GRCh38): 2:79,157,006-79,159,753 (from NCBI)

This gene has 6 transcripts (splice variants), 788 orthologues and 5 paralogues. Biased expression in small intestine (RPKM 2111.4) and duodenum (RPKM 1539.8).

Summary

This gene encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this gene is observed during pancreatic inflammation and liver carcinogenesis. The mature protein also functions as an antimicrobial protein with Antibacterial activity. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Nov 2014]

REG3A Products (3)

mRNA	Protein	Name
NM_002580.3	NP_002571.1	regenerating islet-derived protein 3-alpha precursor
NM_138937.3	NP_620354.1	regenerating islet-derived protein 3-alpha precursor
NM_138938.3	NP_620355.1	regenerating islet-derived protein 3-alpha precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables hormone activity	IDA IDA: Inferred from direct assay	22727489	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	24256734	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of inflammatory response to wounding	IDA IDA: Inferred from direct assay	27830702	GOA
involved in negative regulation of keratinocyte differentiation	IDA IDA: Inferred from direct assay	22727489	GOA
involved in positive regulation of keratinocyte proliferation	IDA IDA: Inferred from direct assay	22727489	GOA
involved in response to wounding	IDA IDA: Inferred from direct assay	22727489	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in extracellular space	IDA IDA: Inferred from direct assay	22727489	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

REG3A Protein Structure

Lectin_C

0
100
175 a.a.

Protein Preferred Names	Protein Names
regenerating islet-derived protein 3-alpha	PAP homologous protein

REG3A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	REG3A	Q06141	ACTB	Homo sapiens	P60709	Anti Tag CoIP	33961781
Intra	REG3A	Q06141	ACTA2	Homo sapiens	P62736	Anti Tag CoIP	28514442
Intra	REG3A	Q06141	ACTC1	Homo sapiens	P68032	Anti Tag CoIP	33961781
Intra	REG3A	Q06141	MDFI	Homo sapiens	Q99750	Validated Y2H	25416956
Intra	REG3A	Q06141	ACTB	Homo sapiens	P60709	Anti Tag CoIP	28514442
Intra	REG3A	Q06141	MDFI	Homo sapiens	Q99750	Y2H Array	25416956
Intra	REG3A	Q06141	KLHL22	Homo sapiens	Q53GT1	Anti Tag CoIP	33961781
Intra	REG3A	Q06141	ACTBL2	Homo sapiens	Q562R1	Anti Tag CoIP	33961781
Intra	REG3A	Q06141	CMAS	Homo sapiens	Q8NFW8	Anti Tag CoIP	33961781
Intra	REG3A	Q06141	ACTBL2	Homo sapiens	Q562R1	Anti Tag CoIP	28514442
Intra	REG3A	Q06141	PUS7	Homo sapiens	Q96PZ0	Anti Tag CoIP	33961781
Intra	REG3A	Q06141	REG3A	Homo sapiens	Q06141	Crosslink	24256734
Intra	REG3A	Q06141	ACTA2	Homo sapiens	P62736	Anti Tag CoIP	33961781
Intra	REG3A	Q06141	SERPINB8	Homo sapiens	P50452	Anti Tag CoIP	33961781
Intra	REG3A	Q06141	REG3A	Homo sapiens	Q06141	3D-EM	24256734
Intra	REG3A	Q06141	CMSS1	Homo sapiens	Q9BQ75	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant REG3A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76002	REG-3 alpha/REG3A Protein, Human (HEK293, His)	Q06141-1 (E27-D175)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Pancreatitis	Mumps Pancreatitis
Acute Pancreatitis	Pancreatitis Pancreatitis, Acute Necrotizing Pancreatitis Nos Acute Pancreas Inflammation
Pancreas Disease	Abnormality Of The Pancreas Pancreatic Diseases
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS18839	Reg3a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11820	REG3A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25331	Reg3a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	REG3A	RGD	RGD:3254
Others	REG3A	NCBI