Polg2 - polymerase (DNA directed), gamma 2, accessory subunit Gene

Also Known as p55; mtPolB; polG-beta

Species: Mus musculus

Gene Type: protein coding
Gene ID: 50776

Summary

Enables DNA-directed DNA Polymerase activity and identical protein binding activity. Acts upstream of or within in utero embryonic development; mitochondrion organization; and respiratory electron transport chain. Located in mitochondrion. Is expressed in early conceptus and secondary oocyte. Human ortholog(s) of this gene implicated in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 4 and mitochondrial DNA depletion syndrome. Orthologous to human POLG2 (DNA Polymerase gamma 2, accessory subunit). [provided by Alliance of Genome Resources, Apr 2022]

Polg2 Products (2)

mRNA Protein Name
NM_001353435.1 NP_001340364.1 DNA polymerase subunit gamma-2, mitochondrial isoform 1b
NM_015810.2 NP_056625.2 DNA polymerase subunit gamma-2, mitochondrial isoform 1a

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-directed DNA polymerase activity IDA
IDA: Inferred from direct assay
10666468 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
11172710 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
23197651 MGI
acts upstream of or within mitochondrial DNA metabolic process IMP
IMP: Inferred from mutant phenotype
23197651 MGI
acts upstream of or within mitochondrial DNA replication IMP
IMP: Inferred from mutant phenotype
23197651 MGI
acts upstream of or within mitochondrion organization IMP
IMP: Inferred from mutant phenotype
23197651 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA polymerase subunit gamma-2, mitochondrial

  • DNA polymerase gamma accessory 55 kDa subunit

  • mitochondrial DNA polymerase accessory subunit

  • mitochondrial polymerase gamma 2

Polg2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Polg2 Q9QZM2 Polg2 Mus musculus Q9QZM2
Density Sedimentation
11172710
Intra
Polg2 Q9QZM2 Polg2 Mus musculus Q9QZM2
X-Ray Diffraction
11172710
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10830 POLG2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22735 Polg2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29249 Polg2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Polg2 NCBI NCBI:11232