CDON - cell adhesion associated, oncogene regulated Gene

Homo sapiens

Also known as CDO; Ihog; CDON1; HPE11; ORCAM

Gene ID: 50937 | Gene type: protein coding

About CDON

Cytogenetic location: 11q24.2 Genomic coordinates (GRCh38): 11:125,956,821-126,063,352 (from NCBI)

This gene has 20 transcripts (splice variants), 202 orthologues, 36 paralogues and is associated with 9 phenotypes. Broad expression in thyroid (RPKM 12.5), ovary (RPKM 11.8) and 17 other tissues.

Summary

This gene encodes a cell surface receptor that is a member of the immunoglobulin superfamily. The encoded protein contains three fibronectin type III domains and five immunoglobulin-like C2-type domains. This protein is a member of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and positively regulates myogenesis. [provided by RefSeq, Aug 2011]

CDON Products(3)

mRNA	Protein	Name
NM_001243597.2	NP_001230526.1	cell adhesion molecule-related/down-regulated by oncogenes isoform 1 precursor
NM_001378964.1	NP_001365893.1	cell adhesion molecule-related/down-regulated by oncogenes isoform 2 precursor
NM_016952.5	NP_058648.4	cell adhesion molecule-related/down-regulated by oncogenes isoform 2 precursor

CDON Protein Structure

Ig_2

I-set

fn3

0
200
400
600
800
1000
1200
1287 a.a.

Protein Preferred Names

Protein Names

cell adhesion molecule-related/down-regulated by oncogenes

Cdon homolog

Recombinant CDON Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70070	CDO Protein, Human (HEK293, His)	Q4KMG0 (D26-P943)	≥95%
HY-P74255	CDO Protein, Human (963a.a, HEK293, His)	Q4KMG0 (M1-D963)	≥95%

Related Diseases

Diseases

Alias

Holoprosencephaly 11

HPE11	Holoprosencephaly-11
Holoprosencephaly, Type 11

Pituitary Stalk Interruption Syndrome

Ectopic Neurohypophysis

Psis

Septopreoptic Holoprosencephaly

Septopreoptic Hpe

Midline Interhemispheric Variant Of Holoprosencephaly

Mih	Mih Type Hpe
Mihf	Mihv
Middle Interhemispheric Fusion Variant	Middle Interhemispheric Variant Of Holoprosencephaly
Syntelencephaly

Lobar Holoprosencephaly

Alobar Holoprosencephaly

Microform Holoprosencephaly

Hpe, Minor Form	Hpe-L
Holoprosencephaly, Minor Form	Holoprosencephaly-Like
Microform Hpe

Semilobar Holoprosencephaly

Coloboma Of Macula

Coloboma	Congenital Ocular Coloboma
Microphthalmia, Isolated, With Coloboma	Agenesis Of Macula
Hereditary Macular Coloboma	Ocular Coloboma
Coloboma Of Eye	Macular Coloboma
Uveoretinal Coloboma

Coloboma, Ocular, Autosomal Dominant

Coloboma, Ocular	Coloboma Of Iris, Choroid, And Retina
Coi	Coloboma, Uveoretinal
COAD	Ocular Coloboma
Uveoretinal Coloboma	Chronic Obstructive Airway Disease

Holoprosencephaly

Holoprosencephaly Sequence	Hpe
Hpe - [Holoprosencephaly]

Solitary Median Maxillary Central Incisor

SMMCI	Fused Incisors
Single Upper Central Incisor	Single Central Maxillary Incisor
Single Median Maxillary Central Incisor	Solitary Median Maxillary Central Incisor Syndrome
Incisors Fused	Incisors, Fused

Generalized Epilepsy With Febrile Seizures Plus, Type 9

GEFSP9	Gefs+9
Generalized Epilepsy With Febrile Seizures Plus 9	Gefs+, Type 9
Generalised Epilepsy With Febrile Seizures Plus 9	Generalised Epilepsy With Febrile Seizures Plus Type 9
Generalized Epilepsy With Febrile Seizures Plus Type 9	Gefs+ Type 9
Epilepsy, Generalized, With Febrile Seizures Plus, Type 9

Brachydactyly, Type A1

Brachydactyly Type A1	BDA1
Farabee-Type Brachydactyly	Farabee Type Brachydactyly
Brachydactyly Farabee Type	Brachydactyly, Farabee Type
Brachydactyly A1	Brachydactyly

Seckel Syndrome 5

SCKL5

Seckel Syndrome, Type 5

Holoprosencephaly 4

HPE4	Holoprosencephaly-4
Holoprosencephaly, Type 4

Myopathy, Congenital, Compton-North

Compton-North Congenital Myopathy	MYPCN
Congenital Lethal Myopathy, Compton-North Type

Megaesophagus

Esophageal Achalasia

Multiple Benign Circumferential Skin Creases On Limbs

Ccsf	Circumferential Skin Creases, Kunze Type
Congenital Circumferential Skin Folds	Kunze-Riehm Syndrome
Kunze Riehm Syndrome	Michelin Tire Baby Syndrome

Fetal Alcohol Spectrum Disorder

Fetal Alcohol Spectrum Disorders

Fetal Alcohol Syndrome

Culler-Jones Syndrome

Postaxial Polydactyly-Anterior Pituitary Anomalies-Facial Dysmorphism Syndrome	CJS
Pallister-Hall Syndrome 2, Formerly	Phs2, Formerly
Pallister-Hall Syndrome 2	Phs2

Greig Cephalopolysyndactyly Syndrome

GCPS	Polysyndactyly With Peculiar Skull Shape
Polysyndactyly With Peculiars Skull Shape	Greig Syndrome
Cephalopolysyndactyly Syndrome	Greig Cephalo-Poly-Syndactyly Syndrome
Cephalopolysyndactyly, Greig Syndrome	Aarskog Syndrome

Basal Cell Nevus Syndrome

Nevoid Basal Cell Carcinoma Syndrome	Gorlin Syndrome
Nbccs	BCNS
Gorlin-Goltz Syndrome	Multiple Basal Cell Nevi, Odontogenic Keratocysts, And Skeletal Anomalies
Cerebral Gigantism Jaw Cysts	Cramer Niederdellmann Syndrome
Gorlin Syndrome Or Gorlin-Goltz Syndrome	Naevoid Basal Cell Carcinoma Syndrome

Encephalopathy, Ethylmalonic

Ethylmalonic Encephalopathy	EE
Epema Syndrome	Encephalopathy, Petechiae, And Ethylmalonic Aciduria
Ethe1 Deficiency	Eme
Syndrome Of Encephalopathy, Petechiae, And Ethylmalonic Aciduria

Pallister-Hall Syndrome

PHS	Hypothalamic Hamartomas
Hypothalamic Hamartoblastoma, Hypopituitarism, Imperforate Anus, And Postaxial Polydactyly	Hypothalamic Hamartoblastoma Syndrome
Hamartoma Of The Hypothalamus	Pallister Hall Syndrome
Hall-Pallister Syndrome	Hypothalamic Hamartoblastoma Hypopituitarism Imperforate Anus And Postaxial Polydactyly
Hamartoma, Hypothalamic

Fetal Alcohol Syndrome

Fetal Alcohol Spectrum Disorders	Arbd
Arnd	Alcohol-Related Birth Defects
Alcohol-Related Neurodevelopmental Disorder	Fas
Fasd	Fetus Or Newborn Affected By Alcohol Transmitted Via Placenta Or Breast Milk
Alcohol Related Birth Defect	Alcohol Related Neurodevelopmental Disorder
Alcohol Affecting Fetus Or Newborn Via Placenta Or Breast Milk	Fetus Or Newborn Affected By Alcohol Transmitted Via Placenta And/Or Breast Milk
Dysmorphism Due To Alcohol	Fetal Etoh Syndrome

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02422	CDON Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CDON	VGNC	VGNC:60716
Bos taurus	CDON	VGNC	VGNC:27151
Canis familiaris	CDON	VGNC	VGNC:39076
Mus musculus	CDON	MGD	MGI:1926387
Rattus norvegicus	CDON	RGD	RGD:708433
Macaca mulatta	CDON	VGNC	VGNC:70961
Others	CDON	NCBI