ECSIT - ECSIT signaling integrator Gene
Also Known as SITPEC
Species: Homo sapiens
About ECSIT
This gene has 20 transcripts (splice variants) and 192 orthologues. Ubiquitous expression in heart (RPKM 25.2), ovary (RPKM 18.4) and 25 other tissues.
Summary
Predicted to enable DNA-binding transcription factor activity and chromatin binding activity. Involved in regulation of oxidoreductase activity and regulation of protein complex stability. Located in cytosol; mitochondrion; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
ECSIT Products (4)
| mRNA | Protein | Name |
|---|---|---|
| NM_001142464.3 | NP_001135936.1 | evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform 2 precursor |
| NM_001142465.3 | NP_001135937.1 | evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform 3 precursor |
| NM_001243204.2 | NP_001230133.1 | evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform 4 precursor |
| NM_016581.5 | NP_057665.2 | evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform 1 precursor |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables molecular adaptor activity |
IDA
IDA: Inferred from direct assay
|
25371197 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
17344420 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in regulation of oxidoreductase activity |
IDA
IDA: Inferred from direct assay
|
17344420 | GOA |
| involved in regulation of protein complex stability |
IDA
IDA: Inferred from direct assay
|
17344420 | GOA |
| involved in toll-like receptor 4 signaling pathway |
IDA
IDA: Inferred from direct assay
|
25371197 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in cytoplasm |
IDA
IDA: Inferred from direct assay
|
17344420 | GOA |
| located in mitochondrion |
IDA
IDA: Inferred from direct assay
|
17344420 | GOA |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
17344420 | GOA |
ECSIT Protein Structure
ECSIT: Evolutionarily conserved signalling intermediate in Toll pathway (40 - 267)
ECSIT_C: C-terminal domain of the ECSIT protein (269 - 393)
- 0
- 100
- 200
- 300
- 400
- 431 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial |
|
ECSIT Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
ECSIT | Q9BQ95 | TARS3 | Homo sapiens | A2RTX5 | 32296183 | |
|
Intra
|
ECSIT | Q9BQ95 | MAGEB2 | Homo sapiens | O15479 | 32296183 | |
|
Intra
|
ECSIT | Q9BQ95 | MAGEB2 | Homo sapiens | O15479 | 32296183 | |
|
Intra
|
ECSIT | Q9BQ95 | CTNNA3 | Homo sapiens | Q9UI47-2 | 32296183 | |
|
Intra
|
ECSIT | Q9BQ95 | APOE | Homo sapiens | P02649 | 21163940 | |
|
Intra
|
ECSIT | Q9BQ95 | APOE | Homo sapiens | P02649 | 21163940 | |
|
Intra
|
ECSIT | Q9BQ95 | PSEN2 | Homo sapiens | P49810 | 21163940 | |
|
Intra
|
ECSIT | Q9BQ95 | PSEN2 | Homo sapiens | P49810 | 21163940 | |
|
Intra
|
ECSIT | Q9BQ95 | PSEN1 | Homo sapiens | P49768 | 21163940 | |
|
Intra
|
ECSIT | Q9BQ95 | PSEN1 | Homo sapiens | P49768 | 21163940 | |
|
Intra
|
ECSIT | Q9BQ95 | NXF1 | Homo sapiens | Q9UBU9 | 32296183 | |
|
Intra
|
ECSIT | Q9BQ95 | FARSA | Homo sapiens | Q9Y285 | 21163940 | |
|
Intra
|
ECSIT | Q9BQ95 | AIRIM | Homo sapiens | Q9NX04 | 32296183 |
Recombinant ECSIT Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P76311 | ECSIT Protein, Human (His) | Q9BQ95-1 (Q246-S431) | ≥ 95%, as determined by reducing SDS-PAGE. |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Mitochondrial Complex I Deficiency, Nuclear Type 20 |
|
|
| Nuclear Type Mitochondrial Complex I Deficiency |
|
|
| Hemophagocytic Lymphohistiocytosis, Familial, 3 |
|
|
| Mitochondrial Complex I Deficiency, Nuclear Type 1 |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Felis catus | ECSIT | VGNC | VGNC:61715 |
| Mus musculus | ECSIT | MGD | MGI:1349469 |
| Rattus norvegicus | ECSIT | RGD | RGD:1359488 |
| Macaca mulatta | ECSIT | VGNC | VGNC:72142 |
| Canis familiaris | ECSIT | VGNC | VGNC:40188 |
| Bos taurus | ECSIT | VGNC | VGNC:28313 |
| Others | ECSIT | NCBI |