ANGPT4 - angiopoietin 4 Gene

Also Known as ANG3; ANG4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51378

About ANGPT4

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:869,900-916,334 (from NCBI)

This gene has 1 transcript (splice variant), 189 orthologues and 25 paralogues. Biased expression in fat (RPKM 1.7), ovary (RPKM 1.2) and 11 other tissues.

Summary

Angiopoietins are proteins with important roles in vascular development and angiogenesis. All Angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells. The protein encoded by this gene functions as an agonist and is an angiopoietin. [provided by RefSeq, Jul 2008]

ANGPT4 Products (2)

mRNA Protein Name
NM_001322809.2 NP_001309738.1 angiopoietin-4 isoform 2 precursor
NM_015985.4 NP_057069.1 angiopoietin-4 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables receptor tyrosine kinase binding IDA
IDA: Inferred from direct assay
10051567 GOA
enables transmembrane receptor protein tyrosine kinase activator activity IDA
IDA: Inferred from direct assay
10051567 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
12958144 GOA
NOT involved in endothelial cell proliferation IDA
IDA: Inferred from direct assay
10025962 GOA
involved in negative regulation of angiogenesis IDA
IDA: Inferred from direct assay
16790085 GOA
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
12958144 GOA
involved in negative regulation of blood vessel endothelial cell migration IDA
IDA: Inferred from direct assay
16790085 GOA
involved in positive regulation of angiogenesis IDA
IDA: Inferred from direct assay
15284220 GOA
involved in positive regulation of blood vessel endothelial cell migration IDA
IDA: Inferred from direct assay
15284220 GOA
involved in positive regulation of endothelial cell migration IDA
IDA: Inferred from direct assay
12958144 GOA
involved in positive regulation of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
15851516 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
10025962 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANGPT4 Protein Structure

Fibrinogen_C

Fibrinogen_C: Fibrinogen beta and gamma chains, C-terminal globular domain (289 - 500)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 503 a.a.
Protein Preferred Names Protein Names

angiopoietin-4

Recombinant ANGPT4 Proteins

Cat. No. Product Name Accession Purity
HY-P74411 Angiopoietin-4 Protein, Human (HEK293, Fc) Q9Y264-1 (M282-I503) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Angiosarcoma

  • Hemangiosarcoma
Glaucoma 3, Primary Congenital, A

  • Buphthalmos

  • Glaucoma, Congenital

  • Congenital Glaucoma

  • Glaucoma 3a, Primary Open Angle, Congenital, Juvenile, Or Adult Onset

  • GLC3A

  • Glc3

  • Buphthalmia

  • Primary Congenital Glaucoma

  • Glaucoma, Primary Open Angle, Juvenile-Onset

  • Simple Buphthalmos

  • Buphthalmus

  • Glaucoma, Primary Open Angle, Adult-Onset

  • Primary Congenital Glaucoma 3a

  • Primary Infantile Glaucoma Type 3a

  • Glaucoma 3a, Primary Congenital

  • Glaucoma, Congenital, Primary, Type 3a

  • Hydrophthalmos

  • Cystic Eyeball
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00689 ANGPT4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18851 Angpt4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25343 Angpt4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ANGPT4 VGNC VGNC:37856
Bos taurus ANGPT4 VGNC VGNC:25889
Macaca mulatta ANGPT4 VGNC VGNC:69812
Rattus norvegicus ANGPT4 RGD RGD:1307539
Felis catus ANGPT4 VGNC VGNC:67557
Mus musculus ANGPT4 MGD MGI:1336887
Others ANGPT4 NCBI