AZIN1 - antizyme inhibitor 1 Gene

Also Known as AZI; AZI1; OAZI; AZIA1; OAZIN; ODC1L

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51582

About AZIN1

Cytogenetic location: 8q22.3 Genomic coordinates (GRCh38): 8:102,826,302-102,864,200 (from NCBI)

This gene has 17 transcripts (splice variants), 293 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 50.0), bone marrow (RPKM 45.4) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. RNA editing of this gene, predominantly in the liver tissue, has been linked to the progression of hepatocellular carcinoma. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2014]

AZIN1 Products (10)

mRNA Protein Name
NM_001301668.3 NP_001288597.1 antizyme inhibitor 1 isoform 2
NM_001363010.1 NP_001349939.1 antizyme inhibitor 1 isoform 3
NM_001363011.1 NP_001349940.1 antizyme inhibitor 1 isoform 3
NM_001363012.1 NP_001349941.1 antizyme inhibitor 1 isoform 3
NM_001363013.1 NP_001349942.1 antizyme inhibitor 1 isoform 4
NM_001363014.1 NP_001349943.1 antizyme inhibitor 1 isoform 4
NM_001363024.1 NP_001349953.1 antizyme inhibitor 1 isoform 1
NM_001363083.1 NP_001350012.1 antizyme inhibitor 1 isoform 1
NM_015878.5 NP_056962.2 antizyme inhibitor 1 isoform 1
NM_148174.4 NP_680479.1 antizyme inhibitor 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of polyamine transmembrane transport IDA
IDA: Inferred from direct assay
18508777 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AZIN1 Protein Structure

Orn_Arg_deC_N

Orn_Arg_deC_N: Pyridoxal-dependent decarboxylase, pyridoxal binding domain (45 - 278)

Orn_DAP_Arg_deC

Orn_DAP_Arg_deC: Pyridoxal-dependent decarboxylase, C-terminal sheet domain (282 - 405)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 448 a.a.
Protein Preferred Names Protein Names

antizyme inhibitor 1

  • ornithine decarboxylase antizyme inhibitor

AZIN1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
AZIN1 O14977 OAZ3 Homo sapiens Q9UMX2
Y2H Array
31515488
Intra
AZIN1 O14977 OAZ3 Homo sapiens Q9UMX2
Y2H Prey Pooling
25416956
Intra
AZIN1 O14977 OAZ3 Homo sapiens Q9UMX2
Validated Y2H
25416956
Intra
AZIN1 O14977 OAZ3 Homo sapiens Q9UMX2
Y2H Array
25416956
Intra
AZIN1 O14977 OAZ3 Homo sapiens Q9UMX2-2
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Dyschromatosis Symmetrica Hereditaria

  • Dyschromatosis Symmetrica Hereditaria 1

  • Reticulate Acropigmentation Of Dohi

  • DSH

  • Dsh1

  • Symmetric Dyschromatosis Of The Extremities

  • Rad

  • Familial Reticulate Acropigmentation Of Dohi

  • Acropigmentation Of Dohi

  • Symmetrical Dyschromatosis Of Extremities
Corpus Luteum Cyst

  • Cystic Corpus Luteum

  • Luteal Cystic Ovary Disease

  • Lutein Cyst

  • Granulosa Lutein Cyst
Childhood Astrocytic Tumor

  • Juvenile Astrocytoma

  • Pediatric Astrocytoma
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Aicardi-Goutieres Syndrome

  • Aicardi Goutieres Syndrome

  • Cree Encephalitis

  • Aicardi-Goutières Syndrome

  • Encephalopathy With Basal Ganglia Calcification

  • Ags

  • Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid

  • Pseudotoxoplasmosis Syndrome

  • Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis

  • Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis

  • Aicardi-Goutieres Syndrome 1
Fanconi Anemia, Complementation Group A

  • Fanconi Anemia

  • Fanconi Pancytopenia

  • Fanconi Anemia Complementation Group A

  • FANCA

  • Fa

  • Fanconi Panmyelopathy

  • Fanconi'S Anemia

  • Fanconi Anaemia

  • Fanconi'S Anaemia

  • Fanconi Hypoplastic Anemia

  • Estren-Dameshek Variant Of Fanconi Anemia

  • Estren-Dameshek Variant Of Fanconi Pancytopenia

  • Fanconi Anemia Estren-Dameshek Variant

  • Fanconis Anemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01296 AZIN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus AZIN1 RGD RGD:61934
Felis catus AZIN1 VGNC VGNC:60052
Bos taurus AZIN1 VGNC VGNC:26369
Mus musculus AZIN1 MGD MGI:1859169
Canis familiaris AZIN1 VGNC VGNC:38329
Macaca mulatta AZIN1 VGNC VGNC:70080
Others AZIN1 NCBI