2. Gene
  3. CPSF3 - cleavage and polyadenylation specific factor 3 Gene

CPSF3 - cleavage and polyadenylation specific factor 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CPSF73; NEDMHS; CPSF-73; NEDMHSN

Gene ID: 51692 | Gene type: protein coding

About CPSF3

Cytogenetic location: 2p25.1 Genomic coordinates (GRCh38): 2:9,423,654-9,473,101 (from NCBI)

This gene has 5 transcripts (splice variants), 245 orthologues, 3 paralogues and is associated with 1 phenotype. Broad expression in testis (RPKM 20.7), lymph node (RPKM 8.6) and 24 other tissues.

Summary

This gene encodes a member of the metallo-beta-lactamase family. The encoded protein is a 73kDa subunit of the cleavage and polyadenylation specificity factor and functions as an endonuclease that recognizes the pre-mRNA 3'-cleavage site AAUAAA prior to polyadenylation. It also cleaves after the pre-mRNA sequence ACCCA during histone 3'-end pre-mRNA processing. [provided by RefSeq, Oct 2012]

CPSF3 Products(5)

mRNA Protein Name
NM_001321833.2 NP_001308762.1 cleavage and polyadenylation specificity factor subunit 3 isoform b
NM_001321834.2 NP_001308763.1 cleavage and polyadenylation specificity factor subunit 3 isoform b
NM_001321835.2 NP_001308764.1 cleavage and polyadenylation specificity factor subunit 3 isoform c
NM_001321836.2 NP_001308765.1 cleavage and polyadenylation specificity factor subunit 3 isoform d
NM_016207.4 NP_057291.1 cleavage and polyadenylation specificity factor subunit 3 isoform a

CPSF3 Protein Structure

Lactamase_B

Lactamase_B: Metallo-beta-lactamase superfamily (21 - 191)

Beta-Casp

Beta-Casp: Beta-Casp domain (246 - 366)

RMMBL

RMMBL: Zn-dependent metallo-hydrolase RNA specificity domain (381 - 421)

CPSF73-100_C

CPSF73-100_C: Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term (477 - 683)

  • 0
  • 200
  • 400
  • 600
  • 684 a.a.
Protein Preferred Names Protein Names

cleavage and polyadenylation specificity factor subunit 3

cleavage and polyadenylation specific factor 3, 73kDa

Related Diseases

Diseases Alias
Neurodevelopmental Disorder With Microcephaly, Hypotonia, Nystagmus, And Seizures

NEDMHS
Neurodevelopmental Disorder With Hypotonia, Microcephaly, And Seizures

NEDHYMS
Oculopharyngeal Muscular Dystrophy

OPMD

Muscular Dystrophy, Oculopharyngeal

Dystrophy, Oculopharyngeal Muscular

Oculopharyngeal Dystrophy

Progressive Muscular Dystrophy, Oculopharyngeal Type

Muscular Dystrophy Oculopharyngeal

Dystrophy, Muscular, Oculopharyngeal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-110133 JTE-607 Inhibitor 99.27% Unkown
HY-RS03118 CPSF3 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CPSF3 VGNC VGNC:61141
Rattus norvegicus CPSF3 RGD RGD:1305767
Macaca mulatta CPSF3 VGNC VGNC:106142
Mus musculus CPSF3 MGD MGI:1859328
Bos taurus CPSF3 VGNC VGNC:27672
Canis familiaris CPSF3 VGNC VGNC:39575