Bok - BCL2-related ovarian killer Gene

Also Known as mtd; matador

Species: Mus musculus

Gene Type: protein coding
Gene ID: 51800

Summary

Enables protein homodimerization activity; signaling receptor binding activity; and ubiquitin protein Ligase binding activity. Involved in several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; ion homeostasis; and regulation of programmed cell death. Acts upstream of or within neuron apoptotic process. Located in several cellular components, including bounding membrane of organelle; mitochondrial membrane; and trans-Golgi network membrane. Is expressed in several structures, including central nervous system; embryo mesenchyme; gut; retina; and vibrissa dermal component. Orthologous to human BOK (BCL2 family Apoptosis regulator BOK). [provided by Alliance of Genome Resources, Apr 2022]

Bok Products (1)

mRNA Protein Name
NM_016778.3 NP_058058.1 bcl-2-related ovarian killer protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23884412 MGI
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
23429263 MGI
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
23884412 MGI
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
26949185 MGI
Biological Process GO Annotation Evidence References Source
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c IMP
IMP: Inferred from mutant phenotype
26015568 MGI
involved in cellular component disassembly involved in execution phase of apoptosis IDA
IDA: Inferred from direct assay
23429263 MGI
involved in negative regulation of mitochondrial depolarization IMP
IMP: Inferred from mutant phenotype
27098698 MGI
involved in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
27098698 MGI
involved in negative regulation of necroptotic process IMP
IMP: Inferred from mutant phenotype
27098698 MGI
involved in negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
27098698 MGI
acts upstream of or within neuron apoptotic process IDA
IDA: Inferred from direct assay
9535847 MGI
involved in positive regulation of PERK-mediated unfolded protein response IMP
IMP: Inferred from mutant phenotype
26015568 MGI
involved in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IDA
IDA: Inferred from direct assay
26949185 MGI
involved in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
26015568 MGI
involved in positive regulation of intrinsic apoptotic signaling pathway IDA
IDA: Inferred from direct assay
23429263 MGI
involved in positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IDA
IDA: Inferred from direct assay
26949185 MGI
involved in protein complex oligomerization IDA
IDA: Inferred from direct assay
26949185 MGI
involved in regulation of cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
27098698 MGI
Cellular Component GO Annotation Evidence References Source
located in cis-Golgi network membrane IDA
IDA: Inferred from direct assay
23429263 MGI
located in early endosome membrane IDA
IDA: Inferred from direct assay
23429263 MGI
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
23429263 MGI
located in mitochondrial membrane IDA
IDA: Inferred from direct assay
23429263 MGI
located in recycling endosome membrane IDA
IDA: Inferred from direct assay
23429263 MGI
located in trans-Golgi network membrane IDA
IDA: Inferred from direct assay
23429263 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

bcl-2-related ovarian killer protein

  • apoptosis activator Mtd

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS18323 Bok Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01570 BOK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24801 Bok Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bok NCBI NCBI:666