Folh1 - folate hydrolase 1 Gene

Also Known as GCP2; mopsm

Species: Mus musculus

Gene Type: protein coding
Gene ID: 53320

Summary

Enables Carboxypeptidase activity and dipeptidase activity. Acts upstream of or within folic acid-containing compound metabolic process and proteolysis. Is integral component of plasma membrane. Is expressed in central nervous system; male reproductive gland or organ; metanephros; and submandibular gland. Orthologous to several human genes including FOLH1 (folate hydrolase 1). [provided by Alliance of Genome Resources, Apr 2022]

Folh1 Products (2)

mRNA Protein Name
NM_001159706.1 NP_001153178.1 glutamate carboxypeptidase 2 isoform 2
NM_016770.3 NP_058050.3 glutamate carboxypeptidase 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables carboxypeptidase activity IDA
IDA: Inferred from direct assay
21908619 MGI
enables dipeptidase activity IDA
IDA: Inferred from direct assay
21908619 MGI
enables peptidase activity IDA
IDA: Inferred from direct assay
11210180 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within folic acid-containing compound metabolic process IDA
IDA: Inferred from direct assay
11210180 MGI
acts upstream of or within proteolysis IDA
IDA: Inferred from direct assay
21908619 MGI
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
21908619 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
11210180 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glutamate carboxypeptidase 2

  • FGCP

  • GCPII

  • N-acetylated-alpha-linked acidic dipeptidase I

  • NAALADase I

  • folylpoly-gamma-glutamate carboxypeptidase

  • glutamate carboxypeptidase II

  • mGCP

  • membrane glutamate carboxypeptidase

  • prostate-specific membrane antigen homolog

  • pteroylpoly-gamma-g

Recombinant Folh1 Proteins

Cat. No. Product Name Accession Purity
HY-P71240 PSMA Protein, Mouse (HEK293, His) O35409 (I44-A752) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700006 PSMA Protein, Mouse (Biotinylated, HEK293, His) O35409 (K45-A752) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P991708 Olsutamig Inhibitor 99.00% Phase 2
HY-P990752 Nezastomig / Phase 2

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05028 FOLH1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18175 Folh1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24649 Folh1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991359 Anti-FOLH1/PSMA Antibody (J591) Inhibitor 95.05% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Folh1 NCBI NCBI:2346