LRP1B - LDL receptor related protein 1B Gene

Also Known as LRP-1B; LRPDIT; LRP-DIT

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 53353

About LRP1B

Cytogenetic location: 2q22.1-q22.2 Genomic coordinates (GRCh38): 2:140,231,423-142,131,016 (from NCBI)

This gene has 5 transcripts (splice variants), 233 orthologues, 14 paralogues and is associated with 159 phenotypes. Biased expression in brain (RPKM 3.0), thyroid (RPKM 1.8) and 4 other tissues.

Summary

This gene encodes a member of the low density lipoprotein (LDL) receptor family. These receptors play a wide variety of roles in normal cell function and development due to their interactions with multiple ligands. Disruption of this gene has been reported in several types of Cancer. [provided by RefSeq, Jun 2016]

LRP1B Products (1)

mRNA	Protein	Name
NM_018557.3	NP_061027.2	low-density lipoprotein receptor-related protein 1B precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of receptor complex	IDA IDA: Inferred from direct assay	23382219	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LRP1B Protein Structure

Ldl_recept_a

EGF_CA

Ldl_recept_b

FXa_inhibition

Ldl_recept_a

FXa_inhibition

Ldl_recept_b

FXa_inhibition

Ldl_recept_b

Ldl_recept_a

cEGF

Ldl_recept_b

FXa_inhibition

Ldl_recept_a

EGF_CA

Ldl_recept_b

EGF

0
800
1600
2400
3200
4000
4599 a.a.

Protein Preferred Names	Protein Names
low-density lipoprotein receptor-related protein 1B	LRP-deleted in tumors

Related Diseases

Diseases	Alias
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Male Urethral Cancer	Male Urethral Malignant Neoplasm
Meier-Gorlin Syndrome 2	MGORS2 Meier-Gorlin Syndrome, Type 2
Epilepsy, Idiopathic Generalized 9	Epilepsy, Idiopathic Generalized, Susceptibility To, 9 EIG9 Epilepsy, Juvenile Myoclonic 6 Idiopathic Generalized Epilepsy 9 Epilepsy, Juvenile Myoclonic, Susceptibility To, 6 Susceptibility To Idiopathic Generalized Epilepsy 9 Juvenile Myoclonic Epilepsy 6 EJM6 Susceptibility To Juvenile Myoclonic Epilepsy 6 Epilepsy, Idiopathic, Generalized, Susceptibility To, Type 9
Hypermethioninemia Due To Adenosine Kinase Deficiency	Adk Hypermethioninemia Hypermethioninemia Encephalopathy Due To Adenosine Kinase Deficiency Hypermethioninemia Encephalopathy Due To Adk Deficiency Mrt8 Mental Retardation, Autosomal Recessive 8, Formerly Mrt8, Formerly HMAKD Mental Retardation, Autosomal Recessive 8
Meningioma, Familial	Meningioma Familial Meningioma Meningioma, Familial, Susceptibility To Meningeal Neoplasm Meningeal Neoplasms Meningiomas Meningioma, Nf2-Related, Somatic Meningioma, Sis-Related Meningothelial Cell Tumor Neoplasm Of The Meninges Primary Meningeal Tumor Familial Multiple Meningioma MNGMA Meningioma, Benign, No Icd-O Subtype Intracranial Meningioma Meningothelial Cell Neoplasm Supratentorial Meningioma Primary Neoplasm Of Spinal Meninges Benign Intracranial Meningioma Benign Meningioma Meningeal Tumours Meningeal Sarcoma Of Unspecified Site Meningothelial Sarcoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07796	LRP1B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29133	Lrp1b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LRP1B	RGD	RGD:1306160
Macaca mulatta	LRP1B	VGNC	VGNC:74443
Mus musculus	LRP1B	MGD	MGI:2151136
Canis familiaris	LRP1B	VGNC	VGNC:42774