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Stk39 - serine/threonine kinase 39 Gene

Also Known as DCHT; Rnl5; SPAK; RF005

Species: Mus musculus

Gene Type: protein coding

Gene ID: 53416

Summary

Enables protein serine/threonine kinase activity. Involved in several processes, including cellular hypotonic response; negative regulation of transport; and protein phosphorylation. Acts upstream of or within several processes, including negative regulation of potassium ion transmembrane transport; negative regulation of protein phosphorylation; and regulation of inflammatory response. Located in apical plasma membrane and basolateral plasma membrane. Is expressed in brain and metanephros. Used to study Gitelman syndrome and pseudohypoaldosteronism. Orthologous to human STK39 (serine/threonine kinase 39). [provided by Alliance of Genome Resources, Apr 2022]

Stk39 Products (5)

mRNA	Protein	Name
NM_001412544.1	NP_001399473.1	STE20/SPS1-related proline-alanine-rich protein kinase isoform 2
NM_001412545.1	NP_001399474.1	STE20/SPS1-related proline-alanine-rich protein kinase isoform 3
NM_001412546.1	NP_001399475.1	STE20/SPS1-related proline-alanine-rich protein kinase isoform 4
NM_001412547.1	NP_001399476.1	STE20/SPS1-related proline-alanine-rich protein kinase isoform 5
NM_016866.3	NP_058562.1	STE20/SPS1-related proline-alanine-rich protein kinase isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables kinase activity	IMP IMP: Inferred from mutant phenotype	16530727	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12386165	MGI
enables protein serine/threonine kinase activity	IGI IGI: Inferred from genetic interaction	24393035	MGI
enables protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	27782176	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in cellular hypotonic response	IGI IGI: Inferred from genetic interaction	24393035	MGI
involved in cellular response to potassium ion	IDA IDA: Inferred from direct assay	31736353	MGI
involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	31786261	MGI
involved in intracellular chloride ion homeostasis	IGI IGI: Inferred from genetic interaction	29459793	MGI
involved in intracellular signal transduction	IGI IGI: Inferred from genetic interaction	24393035	MGI
involved in macrophage activation	IMP IMP: Inferred from mutant phenotype	31786261	MGI
involved in maintenance of lens transparency	IMP IMP: Inferred from mutant phenotype	25515571	MGI
acts upstream of or within monoatomic ion homeostasis	IMP IMP: Inferred from mutant phenotype	21907141	MGI
involved in negative regulation of pancreatic juice secretion	IMP IMP: Inferred from mutant phenotype	21317537	MGI
involved in negative regulation of potassium ion transmembrane transport	IGI IGI: Inferred from genetic interaction	24393035	MGI
involved in negative regulation of potassium ion transmembrane transporter activity	IGI IGI: Inferred from genetic interaction	24393035	MGI
involved in peptidyl-threonine phosphorylation	IGI IGI: Inferred from genetic interaction	24393035	MGI
involved in peptidyl-threonine phosphorylation	IMP IMP: Inferred from mutant phenotype	27782176	MGI
involved in protein autophosphorylation	IMP IMP: Inferred from mutant phenotype	16530727	MGI
involved in protein phosphorylation	IMP IMP: Inferred from mutant phenotype	16530727	MGI
acts upstream of or within regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	21907141	MGI
acts upstream of or within regulation of inflammatory response	IDA IDA: Inferred from direct assay	21705622	MGI
involved in response to aldosterone	IGI IGI: Inferred from genetic interaction	24039833	MGI
involved in response to dietary excess	IMP IMP: Inferred from mutant phenotype	24761002	MGI
involved in sodium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	31736353	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in apical plasma membrane	IDA IDA: Inferred from direct assay	31736353	MGI
located in apical plasma membrane	IDA IDA: Inferred from direct assay	12386165	MGI
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	12386165	MGI
is active in cell body	IDA IDA: Inferred from direct assay	31736353	MGI
located in membrane	IDA IDA: Inferred from direct assay	12386165	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
STE20/SPS1-related proline-alanine-rich protein kinase	Ste-20 related kinase kidney-specific SPAK serine/threonine kinase 39, STE20/SPS1 homolog serine/threonine-protein kinase 39 ste-20-related kinase

Stk39 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Stk39	Q9Z1W9	Slc12a6	Mus musculus	Q924N4-1	Y2H	12386165
Intra	Stk39	Q9Z1W9	Slc12a2	Mus musculus	P55012	Anti Bait CoIP	14563843
Intra	Stk39	Q9Z1W9	Slc12a2	Mus musculus	P55012	Y2H	12386165

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13940	STK39 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21058	Stk39 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27575	Stk39 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Stk39	NCBI	NCBI:27347