PLK1 - polo like kinase 1 Gene

Species: Bos taurus

Gene Type: protein coding
Gene ID: 538238

About PLK1

Primary_assembly 25: 21,334,598-21,345,432 forward strand.ARS-UCD1.2:CM008192.2

This gene has 2 transcripts (splice variants), 188 orthologues and 4 paralogues.

PLK1 Products (1)

mRNA Protein Name
NM_001038173.2 NP_001033262.1 serine/threonine-protein kinase PLK1

PLK1 Protein Structure

PKc_like

PKc_like: cl21453 (42 - 306)

POLO_box_1

POLO_box_1: cd13118 (404 - 491)

POLO_box_2

POLO_box_2: cd13117 (506 - 587)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 602 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase PLK1

  • PLK-1

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12137 Volasertib Inhibitor 99.97% Yes
HY-12137A Volasertib trihydrochloride Inhibitor 99.12% Yes

Clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Phase
HY-12037 Rigosertib sodium Inhibitor 99.57% Phase 3
HY-W286743 Nε-(Carboxymethyl)-L-lysine Activator 99.70% Phase 3
HY-50698 BI 2536 Inhibitor 99.95% Phase 2
HY-15828 Onvansertib Inhibitor 99.86% Phase 2
HY-147298 Plogosertib Inhibitor 98.59% Phase 2
HY-50877 GSK461364 Inhibitor 99.82% Phase 1
HY-15160 TAK-960 Inhibitor 99.75% Phase 1
HY-12045 HMN-214 Inhibitor 99.94% Phase 1
HY-15160B TAK-960 dihydrochloride Inhibitor 99.15% Phase 1
HY-15160A TAK-960 hydrochloride Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (42)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12037A Rigosertib Inhibitor 99.01% Unkown
HY-100789 ON1231320 Inhibitor 99.90% Unkown
HY-11003 GW843682X Inhibitor 99.89% Unkown
HY-15161 Ro3280 Inhibitor 99.46% Unkown
HY-15155 MLN0905 Inhibitor 99.94% Unkown
HY-108597 TC-S 7005 Inhibitor 99.68% Unkown
HY-12134 Poloxin Inhibitor 98.05% Unkown
HY-N0885 Telocinobufagin Inhibitor 99.93% Unkown
HY-15158 SBE13 Hydrochloride Inhibitor 98.56% Unkown
HY-158031 PLK1/BRD4-IN-5 Inhibitor 98.80% Unkown
HY-18009 (Z)-LFM-A13 Inhibitor 99.80% Unkown
HY-179560 PMV6-PEG4-BI2536 Inhibitor 98.47% Unkown
HY-110002 LFM-A13 Inhibitor 99.65% Unkown
HY-15159 Cyclapolin 9 Inhibitor 98.09% Unkown
HY-160558 PLK1/BRD4-IN-3 Inhibitor 98.55% Unkown
HY-173212 PLK1-IN-13 Inhibitor / Unkown
HY-N8692 Dihydrobaicalein Inhibitor 99.94% Unkown
HY-149100 PLK1-IN-6 Inhibitor / Unkown
HY-169579 PLK1-IN-11 Inhibitor 99.52% Unkown
HY-180989 PROTAC PLK1 Degrader-2 Degrader 99.48% Unkown
HY-77195 Poloxime Inhibitor 95.0% Unkown
HY-15158A SBE13 Inhibitor / Unkown
HY-161521 PLK1-IN-10 Inhibitor / Unkown
HY-173233 PLK1-IN-14 Inhibitor / Unkown
HY-N13795 3,4,3'-Tri-O-methylflavellagic acid Inhibitor / Unkown
HY-180990 POI ligand-3 Inhibitor / Unkown
HY-181001 POI ligand-4 Degrader / Unkown
HY-143471 WNY0824 Inhibitor / Unkown
HY-148974 PLK1-IN-5 Inhibitor / Unkown
HY-112395 BTO-1 Inhibitor / Unkown
HY-172880 PLK1-IN-15 Inhibitor / Unkown
HY-111090 GSK461364 analogue 1 Inhibitor / Unkown
HY-W162436 MCC1019 Inhibitor / Unkown
HY-50698A (S)-BI 2536 Inhibitor / Unkown
HY-18651 (E/Z)-Rigosertib sodium / Unkown
HY-181769 Anticancer agent 306 Inhibitor / Unkown
HY-172364 PLK1-IN-12 Inhibitor / Unkown
HY-181000 PROTAC PLK1 Degrader-3 Degrader / Unkown
HY-115589 YLT-11 Inhibitor / Unkown
HY-181030 BDE30671203 Inhibitor / Unkown
HY-172677 IIP0943 Inhibitor / Unkown
HY-181051 PLK1-IN-16 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens PLK1 NCBI NCBI:5347