Cyclapolin 9
Based on 1 Customer Validation
Cyclapolin 9 is a potent, selective and ATP-competitive polo-like kinase 1 (PLK1) inhibitor with an IC50 of 500 nM. Cyclapolin 9 is inactive against other kinases.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.09%
- CAS 番号: 40533-25-3
- 分子式: C9H4F3N3O4S
- 分子量:307.21
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
製品説明
IC50 & Target
[2]|
PLK1 500 nM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
24.8 μM
Compound: cyclapolin 9
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Cytotoxicity against human A549 cells assessed as mitotic progression after 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as mitotic progression after 72 hrs by MTT assay
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[PMID: 17028581] |
| HeLa | IC50 |
6.6 μM
Compound: cyclapolin 9
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Cytotoxicity against human HeLa cells assessed as mitotic progression after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as mitotic progression after 72 hrs by MTT assay
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[PMID: 17028581] |
| HT-29 | IC50 |
7.7 μM
Compound: cyclapolin 9
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Cytotoxicity against human HT-29 cells assessed as mitotic progression after 72 hrs by MTT assay
Cytotoxicity against human HT-29 cells assessed as mitotic progression after 72 hrs by MTT assay
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[PMID: 17028581] |
体外実験
Cyclapolin 9 (3 μM) reduces electric field stimulation (EFS)-induced contractions of prostate strips. The α1-adrenergic smooth muscle contraction in the human prostate can be inhibited by Cyclapolin 9[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
化学情報
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CAS 番号 40533-25-3
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性状 Solid
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分子量 307.21
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分子式 C9H4F3N3O4S
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Color Light yellow to yellow
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SMILES
O=C(C1=[N+]([O-])C2=CC(C(F)(F)F)=CC([N+]([O-])=O)=C2S1)N
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : 20 mg/mL (65.10 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Martin Hennenberg, et al. Inhibition of Prostate Smooth Muscle Contraction by Inhibitors of Polo-Like Kinases. Front Physiol. 2018 Jun 15;9:734. [Content Brief]
[2]. Campbell McInnes, et al. Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance. Nat Chem Biol. 2006 Nov;2(11):608-17. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2551 mL | 16.2755 mL | 32.5510 mL | 81.3776 mL |
| 5 mM | 0.6510 mL | 3.2551 mL | 6.5102 mL | 16.2755 mL | |
| 10 mM | 0.3255 mL | 1.6276 mL | 3.2551 mL | 8.1378 mL | |
| 15 mM | 0.2170 mL | 1.0850 mL | 2.1701 mL | 5.4252 mL | |
| 20 mM | 0.1628 mL | 0.8138 mL | 1.6276 mL | 4.0689 mL | |
| 25 mM | 0.1302 mL | 0.6510 mL | 1.3020 mL | 3.2551 mL | |
| 30 mM | 0.1085 mL | 0.5425 mL | 1.0850 mL | 2.7126 mL | |
| 40 mM | 0.0814 mL | 0.4069 mL | 0.8138 mL | 2.0344 mL | |
| 50 mM | 0.0651 mL | 0.3255 mL | 0.6510 mL | 1.6276 mL | |
| 60 mM | 0.0543 mL | 0.2713 mL | 0.5425 mL | 1.3563 mL |
Cyclapolin 9 関連分類
HY-15159 関連分類
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