2. Cell Cycle/DNA Damage
  3. Polo-like Kinase (PLK)
  4. Cyclapolin 9

Cyclapolin 9 is a potent, selective and ATP-competitive polo-like kinase 1 (PLK1) inhibitor with an IC50 of 500 nM. Cyclapolin 9 is inactive against other kinases.

For research use only. We do not sell to patients.

Cyclapolin 9 Chemical Structure

Cyclapolin 9 Chemical Structure

CAS No. : 40533-25-3

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 308 In-stock
Solution
10 mM * 1 mL in DMSO USD 308 In-stock
Solid
5 mg USD 280 In-stock
10 mg USD 430 In-stock
25 mg USD 690 In-stock
50 mg USD 970 In-stock
100 mg USD 1300 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Cyclapolin 9 Related Antibodies

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Description

Cyclapolin 9 is a potent, selective and ATP-competitive polo-like kinase 1 (PLK1) inhibitor with an IC50 of 500 nM. Cyclapolin 9 is inactive against other kinases[1][2].

IC50 & Target[2]

PLK1

500 nM (IC50)

In Vitro

Cyclapolin 9 (3 μM) reduces electric field stimulation (EFS)-induced contractions of prostate strips. The α1-adrenergic smooth muscle contraction in the human prostate can be inhibited by Cyclapolin 9[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cyclapolin 9 Related Antibodies
Molecular Weight

307.21

Formula

C9H4F3N3O4S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=[N+]([O-])C2=CC(C(F)(F)F)=CC([N+]([O-])=O)=C2S1)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (65.10 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2551 mL 16.2755 mL 32.5510 mL
5 mM 0.6510 mL 3.2551 mL 6.5102 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2551 mL 16.2755 mL 32.5510 mL 81.3776 mL
5 mM 0.6510 mL 3.2551 mL 6.5102 mL 16.2755 mL
10 mM 0.3255 mL 1.6276 mL 3.2551 mL 8.1378 mL
15 mM 0.2170 mL 1.0850 mL 2.1701 mL 5.4252 mL
20 mM 0.1628 mL 0.8138 mL 1.6276 mL 4.0689 mL
25 mM 0.1302 mL 0.6510 mL 1.3020 mL 3.2551 mL
30 mM 0.1085 mL 0.5425 mL 1.0850 mL 2.7126 mL
40 mM 0.0814 mL 0.4069 mL 0.8138 mL 2.0344 mL
50 mM 0.0651 mL 0.3255 mL 0.6510 mL 1.6276 mL
60 mM 0.0543 mL 0.2713 mL 0.5425 mL 1.3563 mL
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Cyclapolin 9 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclapolin 940533-25-3Cyclapolin9Cyclapolin-9Polo-like Kinase (PLK)PLK1ATP-competitiveantitumorprostateα1-adrenergicInhibitorinhibitorinhibit

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