40533-25-3
40533-25-3
Chemical Structure
Cyclapolin 9
- CAS No.: 40533-25-3
- Formula:C9H4F3N3O4S
- Molecular Weight:307.21
IUPAC Name: 2-carbamoyl-7-nitro-5-(trifluoromethyl)benzo[d]thiazole 3-oxide
InChIKey: FHFLXKUKCSDMLD-UHFFFAOYSA-N
SMILES: O=C(C1=[N+]([O-])C2=CC(C(F)(F)F)=CC([N+]([O-])=O)=C2S1)N
Biological Activity: Cyclapolin 9 is a potent, selective and ATP-competitive polo-like kinase 1 (PLK1) inhibitor with an IC50 of 500 nM. Cyclapolin 9 is inactive against other kinases[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Cyclapolin 9 | 98.09% | Cyclapolin 9 is a potent, selective and ATP-competitive polo-like kinase 1 (PLK1) inhibitor with an IC50 of 500 nM. Cyclapolin 9 is inactive against other kinases. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.80
HY-112395BTO-1 -
Similarity Score 0.55
HY-W0057172-Chloro-3-nitro-5-(trifluoromethyl)benzoic acid -
Similarity Score 0.53
HY-W874850Fluorodifen -
Similarity Score 0.52
HY-148706STAT3-IN-17 -
Similarity Score 0.51
HY-B0607RNitisinone (Standard) -
Similarity Score 0.51
HY-W777526Nitisinone-13C6 -
Similarity Score 0.50
HY-135466RProfluralin (Standard) -
Similarity Score 0.50
HY-W714214Ethalfluralin -
Similarity Score 0.50
HY-19621THS-044 -
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References
- [1]. Martin Hennenberg, et al. Inhibition of Prostate Smooth Muscle Contraction by Inhibitors of Polo-Like Kinases. Front Physiol. 2018 Jun 15;9:734. [Content Brief]
- [2]. Campbell McInnes, et al. Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance. Nat Chem Biol. 2006 Nov;2(11):608-17. [Content Brief]
