PLK1 - polo like kinase 1 Gene

Also Known as PLK; STPK13

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5347

About PLK1

Cytogenetic location: 16p12.2 Genomic coordinates (GRCh38): 16:23,678,889-23,690,367 (from NCBI)

This gene has 9 transcripts (splice variants), 184 orthologues and 4 paralogues. Biased expression in testis (RPKM 20.5), lymph node (RPKM 15.8) and 13 other tissues.

Summary

The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during Mitosis and elevated levels are found in many different types of Cancer. Depletion of this protein in Cancer cells dramatically inhibited cell proliferation and induced apoptosis; hence, it is a target for Cancer therapy. [provided by RefSeq, Sep 2015]

PLK1 Products (1)

mRNA	Protein	Name
NM_005030.6	NP_005021.2	serine/threonine-protein kinase PLK1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IMP IMP: Inferred from mutant phenotype	17461553	GOA
enables anaphase-promoting complex binding	IPI IPI: Inferred from physical interaction	18662541	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	21041660	GOA
enables magnesium ion binding	IMP IMP: Inferred from mutant phenotype	17461553	GOA
enables microtubule binding	IDA IDA: Inferred from direct assay	12939256	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12493754	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	17146433	GOA
enables protein kinase activity	IMP IMP: Inferred from mutant phenotype	17461553	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	12639966	GOA
enables protein serine kinase activity	IDA IDA: Inferred from direct assay	21723128	GOA
enables protein serine/threonine kinase activity	EXP EXP: Inferred from Experiment	18378770	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	12524548	GOA
enables protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	19473992	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in G2/M transition of mitotic cell cycle	IDA IDA: Inferred from direct assay	19160488	GOA
involved in centrosome cycle	IMP IMP: Inferred from mutant phenotype	8991084	GOA
involved in double-strand break repair	IDA IDA: Inferred from direct assay	22325354	GOA
involved in double-strand break repair via alternative nonhomologous end joining	IDA IDA: Inferred from direct assay	37440612	GOA
involved in establishment of mitotic spindle orientation	IDA IDA: Inferred from direct assay	23509069	GOA
acts upstream of or within establishment of protein localization	IMP IMP: Inferred from mutant phenotype	18331714	GOA
involved in microtubule bundle formation	IDA IDA: Inferred from direct assay	12939256	GOA
involved in mitotic G2 DNA damage checkpoint signaling	IDA IDA: Inferred from direct assay	18662541	GOA
involved in mitotic cell cycle	IDA IDA: Inferred from direct assay	18615013	GOA
involved in mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	18477460	GOA
involved in mitotic cytokinesis	IDA IDA: Inferred from direct assay	19468302	GOA
involved in mitotic sister chromatid segregation	IMP IMP: Inferred from mutant phenotype	23455478	GOA
involved in mitotic spindle assembly checkpoint signaling	IMP IMP: Inferred from mutant phenotype	23455478	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	18174154	GOA
involved in negative regulation of cyclin-dependent protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	21041660	GOA
involved in negative regulation of double-strand break repair via homologous recombination	IDA IDA: Inferred from direct assay	28512243	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18174154	GOA
involved in nuclear membrane disassembly	IMP IMP: Inferred from mutant phenotype	20679239	GOA
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	16885022	GOA
involved in positive regulation of peptidyl-threonine phosphorylation	IMP IMP: Inferred from mutant phenotype	21041660	GOA
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	19473992	GOA
involved in positive regulation of proteolysis	IDA IDA: Inferred from direct assay	16885022	GOA
involved in positive regulation of ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	15148369	GOA
involved in positive regulation of ubiquitin-protein transferase activity	IMP IMP: Inferred from mutant phenotype	19473992	GOA
involved in protein destabilization	IDA IDA: Inferred from direct assay	16885022	GOA
involved in protein localization to chromatin	IDA IDA: Inferred from direct assay	21111234	GOA
involved in protein localization to nuclear envelope	IMP IMP: Inferred from mutant phenotype	20679239	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	19468300	GOA
involved in protein phosphorylation	IMP IMP: Inferred from mutant phenotype	17461553	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	16885022	GOA
involved in regulation of cytokinesis	IDA IDA: Inferred from direct assay	17351640	GOA
involved in regulation of cytokinesis	IMP IMP: Inferred from mutant phenotype	12939256	GOA
involved in regulation of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	17495026	GOA
involved in regulation of mitotic metaphase/anaphase transition	IDA IDA: Inferred from direct assay	23509069	GOA
involved in regulation of mitotic metaphase/anaphase transition	IMP IMP: Inferred from mutant phenotype	21041660	GOA
involved in regulation of mitotic spindle assembly	IDA IDA: Inferred from direct assay	22621898	GOA
involved in regulation of protein binding	IMP IMP: Inferred from mutant phenotype	21041660	GOA
involved in regulation of protein localization to cell cortex	IDA IDA: Inferred from direct assay	23509069	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in centrosome	IDA IDA: Inferred from direct assay	8991084	GOA
located in kinetochore	IDA IDA: Inferred from direct assay	17617734	GOA
located in microtubule cytoskeleton	IDA IDA: Inferred from direct assay	21041660	GOA
located in midbody	IDA IDA: Inferred from direct assay	19468300	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18615013	GOA
part of outer kinetochore	IDA IDA: Inferred from direct assay	18195732	GOA
located in spindle	IDA IDA: Inferred from direct assay	12939256	GOA
colocalizes with spindle microtubule	IDA IDA: Inferred from direct assay	21041660	GOA
located in spindle midzone	IDA IDA: Inferred from direct assay	19468302	GOA
located in spindle pole	IDA IDA: Inferred from direct assay	18331714	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLK1 Protein Structure

Pkinase

POLO_box

0
100
200
300
400
500
603 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein kinase PLK1	PLK-1 cell cycle regulated protein kinase polo (Drosophia)-like kinase serine/threonine-protein kinase 13

PLK1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PLK1	P53350	ERCC6L	Homo sapiens	Q2NKX8	Anti Tag CoIP	35271311
Intra	PLK1	P53350	ERCC6L	Homo sapiens	Q2NKX8	TAP	20360068
Intra	PLK1	P53350	NEK9	Homo sapiens	Q8TD19	Anti Bait CoIP	21642957
Intra	PLK1	P53350	NEK9	Homo sapiens	Q8TD19	Anti Tag CoIP	21642957
Intra	PLK1	P53350	NEK9	Homo sapiens	Q8TD19	Pull Down	21642957
Intra	PLK1	P53350	C1orf226	Homo sapiens	A1L170	Pull Down	32707033
Intra	PLK1	P53350	PSEN1	Homo sapiens	P49768-2	Validated Y2H	32814053
Intra	PLK1	P53350	PSEN1	Homo sapiens	P49768-2	Y2H Pooling	32814053
Intra	PLK1	P53350	PSEN1	Homo sapiens	P49768-2	Y2H Array	32814053
Intra	PLK1	P53350	CHEK2	Homo sapiens	O96017	IF	12493754
Intra	PLK1	P53350	CHEK2	Homo sapiens	O96017	Protein Kinase Assay	20126263
Intra	PLK1	P53350	CHEK2	Homo sapiens	O96017	Protein Kinase Assay	12493754
Intra	PLK1	P53350	CHEK2	Homo sapiens	O96017	Anti Tag CoIP	12493754
Intra	PLK1	P53350	CHEK2	Homo sapiens	O96017	Anti Bait CoIP	12493754
Cross	PLK1	P53350	Tp53bp1	Mus musculus	P70399-1	Pull Down	20126263
Intra	PLK1	P53350	CENPU	Homo sapiens	Q71F23-1	Pull Down	19597481
Intra	PLK1	P53350	CENPU	Homo sapiens	Q71F23-1	ITC	19597481
Intra	PLK1	P53350	CENPU	Homo sapiens	Q71F23-1	X-Ray Diffraction	19597481
Intra	PLK1	P53350	BIRC6	Homo sapiens	Q9NR09	Anti Tag CoIP	26496610
Intra	PLK1	P53350	BIRC6	Homo sapiens	Q9NR09	Anti Bait CoIP	18329369
Intra	PLK1	P53350	SLX4	Homo sapiens	Q8IY92	Pull Down	32707033
Intra	PLK1	P53350	SLX4	Homo sapiens	Q8IY92	Y2H	19596235
Intra	PLK1	P53350	SLX4	Homo sapiens	Q8IY92	Anti Tag CoIP	25852190
Intra	PLK1	P53350	SLX4	Homo sapiens	Q8IY92	Anti Tag CoIP	19596235
Intra	PLK1	P53350	GTSE1	Homo sapiens	Q9NYZ3	Anti Bait CoIP	20577264
Intra	PLK1	P53350	GTSE1	Homo sapiens	Q9NYZ3	IF	20577264
Intra	PLK1	P53350	NHSL2	Homo sapiens	Q5HYW2	Validated Y2H	32296183
Intra	PLK1	P53350	MCM7	Homo sapiens	P33993	CoIP	15654075
Intra	PLK1	P53350	TANK	Homo sapiens	Q92844	Y2H Array	21988832
Intra	PLK1	P53350	TANK	Homo sapiens	Q92844	Anti Tag CoIP	21988832
Intra	PLK1	P53350	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	PLK1	P53350	TP53	Homo sapiens	P04637	Y2H	16753148
Intra	PLK1	P53350	MCM2	Homo sapiens	P49736	TAP	27173435
Intra	PLK1	P53350	MDM2	Homo sapiens	Q00987	Pull Down	19833129
Intra	PLK1	P53350	MDM2	Homo sapiens	Q00987	Anti Bait CoIP	19833129
Intra	PLK1	P53350	MDM2	Homo sapiens	Q00987	Protein Kinase Assay	19833129
Intra	PLK1	P53350	TP53BP1	Homo sapiens	Q12888	Pull Down	20126263
Intra	PLK1	P53350	TP53BP1	Homo sapiens	Q12888	Pull Down	32707033
Intra	PLK1	P53350	AXIN2	Homo sapiens	Q9Y2T1	Anti Bait CoIP	16815967
Intra	PLK1	P53350	AURKA	Homo sapiens	O14965	Protein Kinase Assay	18615013
Intra	PLK1	P53350	KAT7	Homo sapiens	O95251	Y2H	18250300
Intra	PLK1	P53350	KAT7	Homo sapiens	O95251	Protein Kinase Assay	18250300
Intra	PLK1	P53350	KAT7	Homo sapiens	O95251	Anti Bait CoIP	18250300
Intra	PLK1	P53350	KAT7	Homo sapiens	O95251	Anti Tag CoIP	18250300
Intra	PLK1	P53350	KAT7	Homo sapiens	O95251	Far-WB	18250300
Intra	PLK1	P53350	SPAG9	Homo sapiens	O60271	TAP	27173435
Intra	PLK1	P53350	SPAG9	Homo sapiens	O60271	Anti Tag CoIP	19596235
Intra	PLK1	P53350	BORA	Homo sapiens	Q6PGQ7	Anti Tag CoIP	35271311
Intra	PLK1	P53350	BORA	Homo sapiens	Q6PGQ7	Anti Tag CoIP	18615013
Intra	PLK1	P53350	CDC25C	Homo sapiens	P30307	CoIP	12595692
Intra	PLK1	P53350	CDC25C	Homo sapiens	P30307	Pull Down	19597481
Intra	PLK1	P53350	BORA	Homo sapiens	Q6PGQ7	Pull Down	32707033
Intra	PLK1	P53350	CDC25C	Homo sapiens	P30307	ITC	17307877
Intra	PLK1	P53350	CDC25C	Homo sapiens	P30307	Anti Bait CoIP	19597481
Intra	PLK1	P53350	CDC25C	Homo sapiens	P30307	Anti Tag CoIP	14532005
Intra	PLK1	P53350	CDC25C	Homo sapiens	P30307	X-Ray Diffraction	17307877
Intra	PLK1	P53350	BORA	Homo sapiens	Q6PGQ7	Anti Tag CoIP	33961781
Intra	PLK1	P53350	BORA	Homo sapiens	Q6PGQ7	Anti Tag CoIP	19596235
Intra	PLK1	P53350	BORA	Homo sapiens	Q6PGQ7	Anti Tag CoIP	28514442
Intra	PLK1	P53350	CDC25C	Homo sapiens	P30307	Fluorescence Spectr	17307877
Intra	PLK1	P53350	FADD	Homo sapiens	Q13158	Anti Bait CoIP	20890306
Intra	PLK1	P53350	FADD	Homo sapiens	Q13158	Immunodepletion CoIP	20890306
Intra	PLK1	P53350	HSPA1A	Homo sapiens	P08107	Confocal	21887822
Intra	PLK1	P53350	HSPA1A	Homo sapiens	P08107	Anti Bait CoIP	21887822
Cross	PLK1	P53350	Dvl2	Mus musculus	Q60838	Pull Down	22609948
Intra	PLK1	P53350	PHC2	Homo sapiens	Q8IXK0	Y2H	21988832
Intra	PLK1	P53350	OFD1	Homo sapiens	O75665	Anti Tag CoIP	21988832
Intra	PLK1	P53350	RACGAP1	Homo sapiens	Q9H0H5	Far-WB	19468302
Intra	PLK1	P53350	RACGAP1	Homo sapiens	Q9H0H5	Protein Kinase Assay	19468302
Intra	PLK1	P53350	RACGAP1	Homo sapiens	Q9H0H5	Protein Kinase Assay	19468300
Intra	PLK1	P53350	DVL2	Homo sapiens	O14641	Pull Down	22609948
Intra	PLK1	P53350	DVL2	Homo sapiens	O14641	Pull Down	32707033
Intra	PLK1	P53350	CASP8	Homo sapiens	Q14790	Y2H Array	32814053
Intra	PLK1	P53350	CASP8	Homo sapiens	Q14790	Validated Y2H	32814053
Intra	PLK1	P53350	CASP8	Homo sapiens	Q14790	Y2H Pooling	32814053
Intra	PLK1	P53350	EVI5	Homo sapiens	O60447	Anti Tag CoIP	16439210
Intra	PLK1	P53350	EVI5	Homo sapiens	O60447	Anti Tag CoIP	26496610
Intra	PLK1	P53350	EVI5	Homo sapiens	O60447	Protein Kinase Assay	16439210
Intra	PLK1	P53350	WEE1	Homo sapiens	P30291	Pull Down	32707033
Intra	PLK1	P53350	EIF4B	Homo sapiens	P23588	Confocal	21887822
Intra	PLK1	P53350	EIF4B	Homo sapiens	P23588	Protein Kinase Assay	21887822
Cross	PLK1	P53350	Q99IB8-PRO_0000045602	Hepatitis C virus	Q99IB8-PRO_0000045602	Anti Tag CoIP	20534861

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PLK1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76550	PLK1 Protein, Human (Active, sf9, His)	P53350 (M1-S603)	≥ 90%, as determined by reducing SDS-PAGE.

PLK1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80474	Phospho-PLK1 (Thr210) Antibody (YA161)	WB, ICC/IF, FC	Human
HY-P80972	PLK1 Antibody (YA843)	WB, ICC/IF, IP	Human, Rat
HY-P80972A	PLK1 Antibody (YA843)(PBS only)	WB, ICC/IF, IP	Human, Rat
HY-P84387	PLK1 Antibody (YA4084)	WB, IHC-P, FC, ELISA	Human, Mouse, Rat, Monkey
HY-P84387A	PLK1 Antibody (YA4084)(PBS only)	WB, IHC-P, FC, ELISA	Human, Mouse, Rat, Monkey
HY-P85720	PLK1 Antibody (YA5412)	IHC-P, WB	Human, Mouse, Rat
HY-P86183	PLK1 Antibody (YA5875)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Pancreatic Cancer	Pancreatic Carcinoma Familial Pancreatic Carcinoma Pancreatic Neoplasm Carcinoma Of Pancreas Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Cancer Of The Pancreas Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Lung Cancer Susceptibility 3	Lung Adenocarcinoma Adenocarcinoma Of Lung LNCR3 Adenocarcinoma Of Lung, Susceptibility To Bronchogenic Lung Adenocarcinoma Nonsmall Cell Adenocarcinoma Adenocarcinoma Lung Lung Adenocarcinomas Non-Small Cell Adenocarcinoma
Breast Intraductal Papillomatosis	Breast Papillomatosis Intraductal Papillomatosis Of The Breast
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Polyploidy	Polyploid Polyploidy Syndrome
Lymphoma, Non-Hodgkin, Familial	Non-Hodgkin Lymphoma Lymphoma, Non-Hodgkin NHL Lymphoma, Non-Hodgkin, Somatic Lymphoma, Follicular, Somatic Familial Non-Hodgkin Lymphoma Lymphoma Non-Hodgkins Follicular Lymphoma, Somatic Lymphosarcoma Non-Hodgkins Lymphoma
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Mosaic Variegated Aneuploidy Syndrome	Warburton-Anyane-Yeboa Syndrome Mva Syndrome Mosaic Variegated Aneuplody Microcephaly Syndrome Warburton Anyane Yeboa Syndrome
Primary Autosomal Recessive Microcephaly	Autosomal Recessive Primary Microcephaly Mcph True Microcephaly Microcephalia Vera Microcephaly Vera Microcephaly Primary Hereditary Microcephaly, Primary, Autosomal Recessive Primary Microcephaly
Gastric Cancer	Stomach Cancer Stomach Carcinoma Gastric Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Leukemia, Chronic Myeloid	Chronic Myeloid Leukemia Chronic Myelogenous Leukemia CML Chronic Granulocytic Leukemia Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib Chronic Myeloid Leukaemia Chronic Granulocytic Leukaemia Chronic Myelogenous Leukaemia Myeloid Leukemia, Chronic Leukemia, Chronic Myelogenous Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic Cml - Chronic Myelogenous Leukemia Cgl Chronic Myelocytic Leukemia Leukemia, Chronic Myeloid, Atypical ACML Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Myeloid Leukemia Chronic Leukemia, Myeloid, Chronic Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Cml- [Chronic Myeloid Leukaemia] Cgl - [Chronic Granulocytic Leukaemia] Chronic Myelocytic Leukaemia
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Desmoplastic/Nodular Medulloblastoma Medulloblastoma With Extensive Nodularity Desmoplastic Medulloblastoma Medulloblastoma, Somatic Medulloblastoma, Desmoplastic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Mben Medulloblastoma Desmoplastic Neuroectodermal Tumors, Primitive Medulloblastomas Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Cornelia De Lange Syndrome	De Lange Syndrome Brachmann De Lange Syndrome Brachmann-De Lange Syndrome Cdls Bdls Typus Degenerativus Amstelodamensis
Cataract 36	CTRCT36 Catc4 Autosomal Recessive Congenital Cataract 4 Cataract, Autosomal Recessive Congenital 4 Cataract, Type 36
Ataxia-Telangiectasia	Ataxia Telangiectasia Louis-Bar Syndrome AT At1 Ataxia-Telangiectasia Syndrome Ataxia - Telangiectasia Variant Boder-Sedgwick Syndrome Louis Bar Syndrome Cerebello-Oculocutaneous Telangiectasia Immunodeficiency With Ataxia Telangiectasia A-T Ataxia Telangiectasia Syndrome Atm Telangiectasia, Cerebello-Oculocutaneous Ataxia-Telangiectasia Variant
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Cancer Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Gonococcal Keratitis
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Leukemia, Myeloid, Acute Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Esophageal Cancer	Esophageal Carcinoma Carcinoma Of Esophagus Esophageal Squamous Cell Carcinoma, Somatic Esophageal Carcinoma, Somatic Esophagus Cancer Gastric Cardia Adenocarcinoma Esophageal Neoplasms Esophageal Cancer, Somatic Cancer Of Esophagus Cancer Of Oesophagus Carcinoma Of Oesophagus Ca Lower Third Oesophagus Ca Middle Third Oesophagus Malignant Neoplasm Of Distal Third Of Esophagus Malignant Neoplasm Of Lower Third Of Oesophagus Malignant Neoplasm Of Middle Third Of Oesophagus Malignant Neoplasm Of Proximal Third Of Esophagus Malignant Neoplasm Of Upper Third Esophagus Malignant Tumor Of Abdominal Esophagus Malignant Tumor Of Distal Third Of Esophagus Malignant Tumor Of Proximal Third Of Esophagus Malignant Tumor Of The Middle Third Of The Esophagus ESCR Aerodigestive Tract Cancer Escc Esophageal Squamous Cell Carcinoma Cancer, Esophageal Malignant Neoplasm Of Esophagus Squamous Cell Carcinoma Of Esophagus Malignant Neoplasm Of Middle Third Of Esophagus
Rhabdomyosarcoma
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12137A	Volasertib trihydrochloride	Inhibitor	99.12%	Yes

Clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12137	Volasertib	Inhibitor	99.97%	Phase 3
HY-12037	Rigosertib sodium	Inhibitor	99.57%	Phase 3
HY-15828	Onvansertib	Inhibitor	99.86%	Phase 2
HY-147298	Plogosertib	Inhibitor	98.59%	Phase 2
HY-50877	GSK461364	Inhibitor	99.82%	Phase 1
HY-15160	TAK-960	Inhibitor	99.75%	Phase 1
HY-12045	HMN-214	Inhibitor	99.94%	Phase 1

Pre-clinical Phase

Bioactive Molecules (51)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-50698	BI 2536	Inhibitor	99.95%	Unkown
HY-12037A	Rigosertib	Inhibitor	99.01%	Unkown
HY-100789	ON1231320	Inhibitor	99.90%	Unkown
HY-11003	GW843682X	Inhibitor	99.89%	Unkown
HY-15161	Ro3280	Inhibitor	99.46%	Unkown
HY-15155	MLN0905	Inhibitor	99.94%	Unkown
HY-W286743	Nε-(Carboxymethyl)-L-lysine	Activator	99.70%	Unkown
HY-108597	TC-S 7005	Inhibitor	99.68%	Unkown
HY-12134	Poloxin	Inhibitor	98.05%	Unkown
HY-N0885	Telocinobufagin	Inhibitor	99.93%	Unkown
HY-150259	MDEG-541	Degrader	98.68%	Unkown
HY-15158	SBE13 Hydrochloride	Inhibitor	98.56%	Unkown
HY-123467	Lasiokaurin	Inhibitor	99.68%	Unkown
HY-158031	PLK1/BRD4-IN-5	Inhibitor	98.80%	Unkown
HY-18009	(Z)-LFM-A13	Inhibitor	99.80%	Unkown
HY-179560	PMV6-PEG4-BI2536	Inhibitor	98.47%	Unkown
HY-110002	LFM-A13	Inhibitor	99.65%	Unkown
HY-15159	Cyclapolin 9	Inhibitor	98.09%	Unkown
HY-160558	PLK1/BRD4-IN-3	Inhibitor	98.55%	Unkown
HY-N8692	Dihydrobaicalein	Inhibitor	99.94%	Unkown
HY-173212	PLK1-IN-13	Inhibitor	98.02%	Unkown
HY-149100	PLK1-IN-6	Inhibitor	99.60%	Unkown
HY-15160B	TAK-960 dihydrochloride	Inhibitor	99.15%	Unkown
HY-77195	Poloxime	Inhibitor	95.0%	Unkown
HY-180989	PROTAC PLK1 Degrader-2	Degrader	99.48%	Unkown
HY-169579	PLK1-IN-11	Inhibitor	99.52%	Unkown
HY-15158A	SBE13	Inhibitor	/	Unkown
HY-W162436	MCC1019	Inhibitor	/	Unkown
HY-N13795	3,4,3'-Tri-O-methylflavellagic acid	Inhibitor	/	Unkown
HY-181001	POI ligand-4	Degrader	/	Unkown
HY-148974	PLK1-IN-5	Inhibitor	/	Unkown
HY-208742	ZNL-02-096	Inhibitor	/	Unkown
HY-112395	BTO-1	Inhibitor	/	Unkown
HY-172880	PLK1-IN-15	Inhibitor	/	Unkown
HY-161521	PLK1-IN-10	Inhibitor	/	Unkown
HY-173233	PLK1-IN-14	Inhibitor	/	Unkown
HY-181769	Anticancer agent 306	Inhibitor	/	Unkown
HY-18651	(E/Z)-Rigosertib sodium		/	Unkown
HY-180990	POI ligand-3	Inhibitor	/	Unkown
HY-172364	PLK1-IN-12	Inhibitor	/	Unkown
HY-143471	WNY0824	Inhibitor	/	Unkown
HY-181000	PROTAC PLK1 Degrader-3	Degrader	/	Unkown
HY-115589	YLT-11	Inhibitor	/	Unkown
HY-50698A	(S)-BI 2536	Inhibitor	/	Unkown
HY-111090	GSK461364 analogue 1	Inhibitor	/	Unkown
HY-181030	BDE30671203	Inhibitor	/	Unkown
HY-172677	IIP0943	Inhibitor	/	Unkown
HY-184863	PLK1-IN-17	Inhibitor	/	Unkown
HY-183427	KBJK557	Inhibitor	/	Unkown
HY-181051	PLK1-IN-16	Inhibitor	/	Unkown
HY-15160A	TAK-960 hydrochloride	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PLK1	VGNC	VGNC:33033
Rattus norvegicus	PLK1	RGD	RGD:3352
Mus musculus	PLK1	MGD	MGI:97621
Canis familiaris	PLK1	VGNC	VGNC:44695
Felis catus	PLK1	VGNC	VGNC:68905
Others	PLK1	NCBI