Lpar2 - lysophosphatidic acid receptor 2 Gene

Also Known as Edg4; IPA2; LPA2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 53978

About Lpar2

Chromosome 8: 70,275,079-70,283,752 forward strand.GRCm39:CM001001.3

This gene has 3 transcripts (splice variants), 270 orthologues, 18 paralogues and is associated with 10 phenotypes. Ubiquitous expression in testis adult (RPKM 4.), spleen adult (RPKM 3.8) and 25 other tissues.

Summary

Enables PDZ domain binding activity. Acts upstream of or within G protein-coupled receptor signaling pathway; positive regulation of MAPK cascade; and positive regulation of Rho protein signal transduction. Located in glutamatergic synapse. Is integral component of presynaptic active zone membrane. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; hemolymphoid system gland; and sensory organ. Orthologous to human LPAR2 (lysophosphatidic acid receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Lpar2 Products (1)

mRNA Protein Name
NM_020028.3 NP_064412.2 lysophosphatidic acid receptor 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables PDZ domain binding IPI
IPI: Inferred from physical interaction
15755723 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
15755723 MGI
acts upstream of or within positive regulation of MAPK cascade IDA
IDA: Inferred from direct assay
15755723 MGI
acts upstream of or within positive regulation of Rho protein signal transduction IDA
IDA: Inferred from direct assay
15755723 MGI
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
19766573 MGI
is active in presynaptic active zone membrane IDA
IDA: Inferred from direct assay
19766573 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Lpar2 Protein Structure

7tm_GPCRs

7tm_GPCRs: cl28897 (29 - 302)

7tm_GPCRs

7tm_GPCRs: cd14964 (31 - 55)

7tm_GPCRs

7tm_GPCRs: cd14964 (64 - 85)

7tm_GPCRs

7tm_GPCRs: cd14964 (101 - 123)

7tm_GPCRs

7tm_GPCRs: cd14964 (145 - 161)

7tm_GPCRs

7tm_GPCRs: cd14964 (182 - 205)

7tm_GPCRs

7tm_GPCRs: cd14964 (236 - 258)

7tm_GPCRs

7tm_GPCRs: cd14964 (270 - 295)

  • 0
  • 100
  • 200
  • 300
  • 348 a.a.
Protein Preferred Names Protein Names

lysophosphatidic acid receptor 2

  • LPA receptor 2

  • LPA-2

  • endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 4

  • lysophosphatidic acid receptor Edg-4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-107616 H2L5186303 Antagonist 98.50% Unkown
HY-100676 GRI977143 Agonist 99.29% Unkown
HY-148291 BrP-LPA sodium Antagonist / Unkown
HY-178845 Decyl phosphate Modulator / Unkown
HY-W725737 BrP-LPA Antagonist / Unkown
HY-118539 NSC12404 Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lpar2 NCBI NCBI:9170