Pmm2 - phosphomannomutase 2 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 54128

Summary

Predicted to enable phosphomannomutase activity. Predicted to be involved in mannose metabolic process and protein N-linked glycosylation. Located in cytoplasm and neuronal cell body. Is expressed in several structures, including alimentary system; brain; liver; nose; and respiratory system. Used to study congenital disorder of glycosylation type I. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation and congenital disorder of glycosylation Ia. Orthologous to human PMM2 (phosphomannomutase 2). [provided by Alliance of Genome Resources, Apr 2022]

Pmm2 Products (2)

mRNA Protein Name
NM_001362485.1 NP_001349414.1 phosphomannomutase 2 isoform 2
NM_016881.3 NP_058577.1 phosphomannomutase 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phosphomannomutase activity IMP
IMP: Inferred from mutant phenotype
27053713 MGI
Biological Process GO Annotation Evidence References Source
involved in GDP-mannose biosynthetic process from glucose IMP
IMP: Inferred from mutant phenotype
27053713 MGI
involved in GDP-mannose biosynthetic process from mannose IMP
IMP: Inferred from mutant phenotype
27053713 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16115222 MGI
is active in cytosol IDA
IDA: Inferred from direct assay
27053713 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
16115222 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

phosphomannomutase 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-124890 Thr101 Inhibitor 99.48% Unkown
HY-RS10767 PMM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-113002 α-D-Glucose 1,6-bisphosphate Activator / Unkown
HY-RS19368 Pmm2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25860 Pmm2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pmm2 NCBI NCBI:5373