Car2 - carbonic anhydrase 2 Gene

Also Known as Ca2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 54231

About Car2

Primary_assembly 2: 86,741,626-86,756,818 reverse strand.mRatBN7.2:CM026975.1

This gene has 2 transcripts (splice variants), 285 orthologues, 16 paralogues and is associated with 11 phenotypes. Biased expression in Spleen (RPKM 2474.6), Kidney (RPKM 1633.5) and 3 other tissues.

Summary

Enables carbonate dehydratase activity. Involved in several processes, including positive regulation of bone resorption; positive regulation of cellular pH reduction; and positive regulation of osteoclast differentiation. Located in several cellular components, including apical part of cell; basolateral plasma membrane; and microvillus. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 3 and osteopetrosis. Orthologous to human CA2 (Carbonic Anhydrase 2). [provided by Alliance of Genome Resources, Apr 2022]

Car2 Products (1)

mRNA Protein Name
NM_019291.1 NP_062164.1 carbonic anhydrase 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables carbonate dehydratase activity IDA
IDA: Inferred from direct assay
6425289 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
10350214 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to fluid shear stress IEP
IEP: Inferred from expression pattern
16777439 RGD
involved in estrous cycle IEP
IEP: Inferred from expression pattern
23869188 RGD
involved in kidney development IEP
IEP: Inferred from expression pattern
9655354 RGD
involved in odontogenesis of dentin-containing tooth IEP
IEP: Inferred from expression pattern
8766158 RGD
involved in positive regulation of bone resorption IMP
IMP: Inferred from mutant phenotype
8674544 RGD
involved in positive regulation of cellular pH reduction IMP
IMP: Inferred from mutant phenotype
9665810 RGD
involved in positive regulation of osteoclast differentiation IMP
IMP: Inferred from mutant phenotype
10523502 RGD
involved in response to estrogen IEP
IEP: Inferred from expression pattern
16188437 RGD
involved in response to formaldehyde IEP
IEP: Inferred from expression pattern
17285311 RGD
involved in response to pH IEP
IEP: Inferred from expression pattern
8141264 RGD
involved in response to steroid hormone IEP
IEP: Inferred from expression pattern
1903702 RGD
involved in response to zinc ion IEP
IEP: Inferred from expression pattern
16140947 RGD
Cellular Component GO Annotation Evidence References Source
located in apical part of cell IDA
IDA: Inferred from direct assay
2129509 RGD
located in axon IDA
IDA: Inferred from direct assay
3110266 RGD
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
16575514 RGD
located in cytoplasm IDA
IDA: Inferred from direct assay
102414 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
14644548 RGD
located in microvillus IDA
IDA: Inferred from direct assay
16575514 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Car2 Protein Structure

alpha_CA

alpha_CA: cl00012 (0 - 258)

  • 0
  • 100
  • 200
  • 260 a.a.
Protein Preferred Names Protein Names

carbonic anhydrase 2

  • CA-II

  • carbonate dehydratase II

  • carbonic anhydrase II

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-D2620 CAR-2 Inducer / Phase 1

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-183912 PY-4Car2 Inhibitor / Unkown
HY-RS01768 CA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01909 Car2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01910 Car2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01934 CARS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22414 Cars2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28937 Cars2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown