Gata4 - GATA binding protein 4 Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 54254

Summary

Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; NFAT protein binding activity; and cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including cell growth involved in cardiac muscle cell development; positive regulation of BMP signaling pathway; and transdifferentiation. Located in nucleus. Used to study myocardial infarction. Biomarker of congenital heart disease and pulmonary hypertension. Human ortholog(s) of this gene implicated in congenital heart disease (multiple). Orthologous to human GATA4 (GATA binding protein 4). [provided by Alliance of Genome Resources, Apr 2022]

Gata4 Products (1)

mRNA	Protein	Name
NM_144730.1	NP_653331.1	transcription factor GATA-4

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	8007990	RGD
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	11994297	RGD
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	10330176	RGD
enables NFAT protein binding	IPI IPI: Inferred from physical interaction	22198280	RGD
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	11994297	RGD
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	20855530	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	20081228	RGD
enables sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	12704188	RGD
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	12606287	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cardiac muscle cell differentiation	IEP IEP: Inferred from expression pattern	20486789	RGD
involved in cell growth involved in cardiac muscle cell development	IDA IDA: Inferred from direct assay	20971938	RGD
involved in cellular response to glucose stimulus	IEP IEP: Inferred from expression pattern	17525155	RGD
involved in negative regulation of autophagy	IMP IMP: Inferred from mutant phenotype	19901028	RGD
involved in positive regulation of BMP signaling pathway	IDA IDA: Inferred from direct assay	12606287	RGD
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11994297	RGD
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11827958	RGD
involved in regulation of cardiac muscle cell contraction	IMP IMP: Inferred from mutant phenotype	21702924	RGD
involved in response to mechanical stimulus	IDA IDA: Inferred from direct assay	21084678	RGD
involved in response to vitamin A	IEP IEP: Inferred from expression pattern	23333085	RGD
involved in transdifferentiation	IMP IMP: Inferred from mutant phenotype	23948075	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
transcription factor GATA-4	DNA-binding protein GATA-GT2 GATA-binding factor 4

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-128326	ZAK-IN-1	Inhibitor	98.43%	Unkown
HY-103484	GATA4-NKX2-5-IN-1	Inhibitor	99.24%	Unkown
HY-RS05292	GATA4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174481	Mouse Gata4 mRNA		/	Unkown
HY-174673	Human GATA4 mRNA		/	Unkown
HY-RS18176	Gata4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24650	Gata4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gata4	NCBI	NCBI:2626