SNRK - SNF related kinase Gene

Also Known as HSNFRK

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54861

About SNRK

Cytogenetic location: 3p22.1 Genomic coordinates (GRCh38): 3:43,286,540-43,351,143 (from NCBI)

This gene has 8 transcripts (splice variants), 228 orthologues and 17 paralogues. Ubiquitous expression in bone marrow (RPKM 23.2), thyroid (RPKM 20.1) and 25 other tissues.

Summary

SNRK is a member of the sucrose nonfermenting (SNF)-related kinase family of serine/threonine kinases (Kertesz et al., 2002 [PubMed 12234663]).[supplied by OMIM, Apr 2009]

SNRK Products (3)

mRNA Protein Name
NM_001100594.2 NP_001094064.1 SNF-related serine/threonine-protein kinase isoform 1
NM_001330750.2 NP_001317679.1 SNF-related serine/threonine-protein kinase isoform 2
NM_017719.5 NP_060189.3 SNF-related serine/threonine-protein kinase isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
12234663 GOA
enables magnesium ion binding IDA
IDA: Inferred from direct assay
12234663 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
12234663 GOA
Biological Process GO Annotation Evidence References Source
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
12234663 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNRK Protein Structure

Pkinase

Pkinase: Protein kinase domain (16 - 269)

  • 0
  • 200
  • 400
  • 600
  • 765 a.a.
Protein Preferred Names Protein Names

SNF-related serine/threonine-protein kinase

  • SNF-1 related kinase

Related Diseases

Diseases Alias
Skin Angiosarcoma

  • Angiosarcoma Of Skin

  • Hemangiosarcoma Of The Skin

  • Haemangiosarcoma Of Skin

  • Lymphangiosarcoma Of Skin

  • Cutaneous Angiosarcoma

  • Malignant Haemangioendothelioma Of Skin
Liver Angiosarcoma

  • Angiosarcoma Of Liver

  • Angiosarcoma Of The Liver

  • Hemangiosarcoma Of The Liver

  • Primary Angiosarcoma Of Liver

  • Kupffer Cell Sarcoma Of Liver

  • Kupffer Cell Sarcoma Of Unspecified Site
Neuronopathy, Distal Hereditary Motor, Type Viii

  • Autosomal Dominant Congenital Benign Spinal Muscular Atrophy

  • HMN8

  • Dhmn8

  • Neuropathy, Distal Hereditary Motor, Type Viii

  • Distal Hereditary Motor Neuronopathy Type 8

  • Autosomal Dominant Benign Distal Spinal Muscular Atrophy

  • Congenital Benign Spinal Muscular Atrophy With Contractures

  • Congenital Nonprogressive Spinal Muscular Atrophy

  • Spinal Muscular Atrophy, Distal, Congenital Nonprogressive

  • Spinal Muscular Atrophy, Congenital Benign, With Contractures

  • Distal Hereditary Motor Neuropathy Type Viii

  • Neuronopathy, Distal Hereditary Motor, 8

  • Distal Spinal Muscular Atrophy, Congenital Non-Progressive

  • Spinal Muscular Atrophy Congenital Benign With Contractures
Breast Angiosarcoma

  • Angiosarcoma Of The Breast

  • Hemangiosarcoma Of The Breast

  • Primary Angiosarcoma Of Breast
Skin Sarcoma

  • Cutaneous Sarcoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148062 RSS0680 Degrader 99.85% Unkown
HY-RS13495 SNRK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-164125 6-O-Bis[1-(2-nitrophenyl)-ethoxyphosphoryl]-D-trehalose Inhibitor / Unkown
HY-RS20821 Snrk Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27335 Snrk Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SNRK RGD RGD:69653
Macaca mulatta SNRK VGNC VGNC:84074
Canis familiaris SNRK VGNC VGNC:54995
Mus musculus SNRK MGD MGI:108104
Bos taurus SNRK VGNC VGNC:50156
Felis catus SNRK VGNC VGNC:65531
Others SNRK NCBI