PARP16 - poly(ADP-ribose) polymerase family member 16 Gene

Also Known as ARTD15; pART15; C15orf30

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 54956

About PARP16

This gene has 6 transcripts (splice variants), 209 orthologues and 2 paralogues. Ubiquitous expression in ovary (RPKM 4.7), endometrium (RPKM 3.3) and 25 other tissues.

Summary

Enables kinase binding activity; pentosyltransferase activity; and protein serine/threonine kinase activator activity. Involved in several processes, including IRE1-mediated unfolded protein response; positive regulation of protein serine/threonine kinase activity; and protein ADP-ribosylation. Located in endoplasmic reticulum tubular network and nuclear envelope. [provided by Alliance of Genome Resources, Apr 2022]

PARP16 Products (3)

mRNA	Protein	Name
NM_001316943.2	NP_001303872.1	protein mono-ADP-ribosyltransferase PARP16 isoform 2
NM_001316944.2	NP_001303873.1	protein mono-ADP-ribosyltransferase PARP16 isoform 3
NM_017851.6	NP_060321.3	protein mono-ADP-ribosyltransferase PARP16 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables NAD+-protein ADP-ribosyltransferase activity	IDA IDA: Inferred from direct assay	25043379	GOA
enables NAD+-protein poly-ADP-ribosyltransferase activity	IMP IMP: Inferred from mutant phenotype	22701565	GOA
enables NAD+-protein-aspartate ADP-ribosyltransferase activity	IDA IDA: Inferred from direct assay	25043379	GOA
enables NAD+-protein-glutamate ADP-ribosyltransferase activity	IDA IDA: Inferred from direct assay	25043379	GOA
enables NAD+-protein-lysine ADP-ribosyltransferase activity	IDA IDA: Inferred from direct assay	25043379	GOA
enables kinase binding	IPI IPI: Inferred from physical interaction	23103912	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22701565	GOA
enables protein serine/threonine kinase activator activity	IMP IMP: Inferred from mutant phenotype	23103912	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in IRE1-mediated unfolded protein response	IMP IMP: Inferred from mutant phenotype	23103912	GOA
involved in endoplasmic reticulum unfolded protein response	IMP IMP: Inferred from mutant phenotype	23103912	GOA
involved in negative regulation of cytoplasmic translation	IDA IDA: Inferred from direct assay	34314702	GOA
involved in protein auto-ADP-ribosylation	IDA IDA: Inferred from direct assay	25043379	GOA
involved in protein auto-ADP-ribosylation	IMP IMP: Inferred from mutant phenotype	22701565	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum	IMP IMP: Inferred from mutant phenotype	23103912	GOA
located in endoplasmic reticulum tubular network	IMP IMP: Inferred from mutant phenotype	22701565	GOA
located in nuclear envelope	IDA IDA: Inferred from direct assay	22701565	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PARP16 Protein Structure

PARP

0
100
200
300
323 a.a.

Protein Preferred Names	Protein Names
protein mono-ADP-ribosyltransferase PARP16	ADP-ribosyltransferase diphtheria toxin-like 15

PARP16 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PARP16	Q8N5Y8	FLJ13057	Homo sapiens	Q53SE7	Validated Y2H	25416956
Intra	PARP16	Q8N5Y8	FLJ13057	Homo sapiens	Q53SE7	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Osebold-Remondini Syndrome	Brachydactyly Type A6 Brachymesophalangy With Mesomelic Short Limbs And Carpal And Tarsal Osseous Abnormalities Bda6 Brachydactyly, Type A6
Arthrogryposis, Renal Dysfunction, And Cholestasis 1	Arc Syndrome ARCS1 Arthrogryposis Renal Dysfunction Cholestasis Syndrome Arthrogryposis-Renal Dysfunction-Cholestasis Syndrome Arcs Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome Arthrogryposis, Renal Dysfunction, And Cholestasis Arthrogryposis-Renal Dysfunction-Cholestasis Arthrogryposis - Renal Dysfunction - Cholestasis Arthrogryposis Multiplex Congenita, Renal Dysfunction, And Cholestasis Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome 1 Arthrogryposis Renal Dysfunction And Cholestasis 1 Arthrogryposis With Renal Dysfunction And Cholestasis Syndrome Arthrogryposis, Renal Dysfunction, Cholestasis, Type 1 Kidney Failure Renal Insufficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-150221	DB008	Inhibitor	98.47%	Unkown
HY-148754	PARP10-IN-3	Inhibitor	98.72%	Unkown
HY-148753	PARP10-IN-2	Inhibitor	98.02%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PARP16	MGD	MGI:2446133
Macaca mulatta	PARP16	VGNC	VGNC:84416
Bos taurus	PARP16	VGNC	VGNC:53576
Rattus norvegicus	PARP16	RGD	RGD:1306243
Felis catus	PARP16	VGNC	VGNC:80892
Others	PARP16	NCBI