HJURP - Holliday junction recognition protein Gene

Also Known as FAKTS; URLC9; hFLEG1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55355

About HJURP

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:233,836,702-233,854,535 (from NCBI)

This gene has 9 transcripts (splice variants) and 113 orthologues. Biased expression in bone marrow (RPKM 15.6), testis (RPKM 7.0) and 11 other tissues.

Summary

Enables histone binding activity and identical protein binding activity. Involved in several processes, including CENP-A containing chromatin assembly; regulation of DNA binding activity; and regulation of protein-containing complex assembly. Located in kinetochore; mitochondrion; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]

HJURP Products (3)

mRNA Protein Name
NM_001282962.2 NP_001269891.1 Holliday junction recognition protein isoform b
NM_001282963.2 NP_001269892.1 Holliday junction recognition protein isoform c
NM_018410.5 NP_060880.3 Holliday junction recognition protein isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables histone binding IDA
IDA: Inferred from direct assay
21478274 GOA
enables histone binding IPI
IPI: Inferred from physical interaction
19410544 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
23771058 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19410544 GOA
Biological Process GO Annotation Evidence References Source
involved in CENP-A containing chromatin assembly IMP
IMP: Inferred from mutant phenotype
19410544 GOA
involved in chromosome segregation IMP
IMP: Inferred from mutant phenotype
19410544 GOA
involved in regulation of DNA binding IDA
IDA: Inferred from direct assay
21478274 GOA
involved in regulation of protein-containing complex assembly IDA
IDA: Inferred from direct assay
21478274 GOA
Cellular Component GO Annotation Evidence References Source
located in chromosome, centromeric region IDA
IDA: Inferred from direct assay
19410544 GOA
located in kinetochore IDA
IDA: Inferred from direct assay
19410545 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
19410545 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HJURP Protein Structure

Scm3

Scm3: Centromere protein Scm3 (16 - 76)

HJURP_mid

HJURP_mid: Holliday junction recognition protein-associated repeat (271 - 386)

HJURP_C

HJURP_C: Holliday junction regulator protein family C-terminal repeat (409 - 470)

HJURP_C

HJURP_C: Holliday junction regulator protein family C-terminal repeat (554 - 614)

  • 0
  • 200
  • 400
  • 600
  • 748 a.a.
Protein Preferred Names Protein Names

Holliday junction recognition protein

  • 14-3-3-associated AKT substrate

HJURP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HJURP Q8NCD3 CENPA Homo sapiens P49450
Pull Down
19410544
Intra
HJURP Q8NCD3 CENPA Homo sapiens P49450
Anti Bait CoIP
19410545
Intra
HJURP Q8NCD3 CENPA Homo sapiens P49450
Anti Tag CoIP
19410545
Intra
HJURP Q8NCD3 CENPA Homo sapiens P49450
Confocal
19410545
Intra
HJURP Q8NCD3 CENPA Homo sapiens P49450
Pull Down
21478274
Intra
HJURP Q8NCD3 H4C16 Homo sapiens P62805
Pull Down
19410544
Intra
HJURP Q8NCD3 HJURP Homo sapiens Q8NCD3
GMS
23771058
Intra
HJURP Q8NCD3 HJURP Homo sapiens Q8NCD3
Anti Tag CoIP
23771058
Intra
HJURP Q8NCD3 HJURP Homo sapiens Q8NCD3
Complementation
23771058
Intra
HJURP Q8NCD3 HJURP Homo sapiens Q8NCD3
Pull Down
23771058
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HJURP Proteins

Cat. No. Product Name Accession Purity
HY-P72226 HJURP Protein, Human (His-SUMO) Q8NCD3-1 (M1-V748) ≥ 90%, as determined by reducing SDS-PAGE.

HJURP Antibodies

Cat. No. Product Name Application Reactivity
HY-P83242 HJURP Antibody (YA2987) WB, IHC-P Human
HY-P83242A HJURP Antibody (YA2987)(PBS only) WB, IHC-P Human

Related Diseases

Diseases Alias
Luminal Breast Carcinoma A

  • Breast Tumor Luminal

  • Luminal A Breast Carcinoma

  • Luminal Breast Cancer
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Filippi Syndrome

  • Scott Craniodigital Syndrome With Mental Retardation

  • Type 1 Syndactyly-Microcephaly-Intellectual Disability Syndrome

  • FLPIS

  • Scott Bryant Graham Syndrome

  • Craniodigital-Intellectual Disability Syndrome

  • Scott Craniodigital Syndrome

  • Scott-Bryant-Graham Syndrome

  • Syndactyly, Type I, With Microcephaly And Mental Retardation

  • Syndactyly Type I With Microcephaly And Intellectual Disability

  • Unusual Facial Appearance, Microcephaly, Growth And Intellectual Disability And Syndactyly

  • Craniodigital Syndrome With Intellectual Disability

  • Craniodigital Syndrome-Intellectual Disability Syndrome

  • Craniodigital Syndrome-Intellectual Disability, Scott Type

  • Intellectual Disability-Craniodigital Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06190 HJURP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19204 Hjurp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25692 Hjurp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta HJURP VGNC VGNC:73442
Mus musculus HJURP MGD MGI:2685821
Rattus norvegicus HJURP RGD RGD:1305846
Bos taurus HJURP VGNC VGNC:29863
Canis familiaris HJURP VGNC VGNC:41697
Felis catus HJURP VGNC VGNC:107555
Others HJURP NCBI