CHRNA9 - cholinergic receptor nicotinic alpha 9 subunit Gene

Also Known as NACHRA9; HSA243342

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55584

About CHRNA9

Cytogenetic location: 4p14 Genomic coordinates (GRCh38): 4:40,335,333-40,355,217 (from NCBI)

This gene has 3 transcripts (splice variants), 260 orthologues and 45 paralogues. Low expression observed in reference dataset.

Summary

This gene is a member of the ligand-gated ionic channel family and nicotinic acetylcholine receptor gene superfamily. It encodes a plasma membrane protein that forms homo- or hetero-oligomeric divalent cation channels. This protein is involved in cochlea hair cell development and is also expressed in the outer hair cells (OHCs) of the adult cochlea. [provided by RefSeq, Feb 2012]

CHRNA9 Products (1)

mRNA	Protein	Name
NM_017581.4	NP_060051.2	neuronal acetylcholine receptor subunit alpha-9 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables acetylcholine-gated monoatomic cation-selective channel activity	IDA IDA: Inferred from direct assay	25282151	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25282151	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within positive regulation of cytosolic calcium ion concentration	IGI IGI: Inferred from genetic interaction	18420419	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of acetylcholine-gated channel complex	IDA IDA: Inferred from direct assay	25282151	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	25282151	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHRNA9 Protein Structure

Neur_chan_LBD

Neur_chan_memb

0
100
200
300
400
479 a.a.

Protein Preferred Names	Protein Names
neuronal acetylcholine receptor subunit alpha-9	NACHR alpha 9

CHRNA9 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	CHRNA9	Q9UGM1	3l21v_bunmu	Bungarus multicinctus	P60616	X-Ray Diffraction	25282151
Cross	CHRNA9	Q9UGM1	3l21v_bunmu	Bungarus multicinctus	P60616	Pull Down	25282151

Cross: Cross-species interaction Intra: Intraspecies interaction

CHRNA9 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81023	CHRNA9 Antibody	WB, IHC-P	Human, Rat

Related Diseases

Diseases	Alias
Tobacco Addiction	Nicotine Dependence Tobacco Addiction, Susceptibility To Nicotine Addiction Tobacco Use Disorder Smoking Habit Nicotine Dependence, Protection Against Nicotine Addiction, Protection From Cigarette Habituation Cigarette Habituation, Susceptibility To Smoking Habit, Susceptibility To Nicotine Dependence, Susceptibility To Nicotine Addiction, Susceptibility To Addiction, Tobacco, Susceptibility To Compulsive Tobacco User Syndrome Tobacco Dependence Tobacco Dependence Syndrome Cigarette Addiction Cigarette Dependence Smoking Addiction Smokers Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02673	CHRNA9 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CHRNA9	VGNC	VGNC:27329
Canis familiaris	CHRNA9	VGNC	VGNC:39241
Felis catus	CHRNA9	VGNC	VGNC:78469
Macaca mulatta	CHRNA9	VGNC	VGNC:70947
Rattus norvegicus	CHRNA9	RGD	RGD:621534
Mus musculus	CHRNA9	MGD	MGI:1202403
Others	CHRNA9	NCBI