KIF21A - kinesin family member 21A Gene

Also Known as FEOM1; CFEOM1; FEOM3A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55605

About KIF21A

Cytogenetic location: 12q12 Genomic coordinates (GRCh38): 12:39,293,228-39,443,120 (from NCBI)

This gene has 14 transcripts (splice variants), 287 orthologues, 41 paralogues and is associated with 4 phenotypes. Broad expression in brain (RPKM 25.3), kidney (RPKM 9.6) and 22 other tissues.

Summary

This gene encodes a member of the KIF4 subfamily of kinesin-like motor proteins. The encoded protein is characterized by an N-terminal motor domain a coiled-coil stalk domain and a C-terminal WD-40 repeat domain. This protein may be involved in microtubule dependent transport. Mutations in this gene are the cause of congenital fibrosis of extraocular muscles-1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010]

KIF21A Products (7)

mRNA	Protein	Name
NM_001173463.2	NP_001166934.1	kinesin-like protein KIF21A isoform 3
NM_001173464.2	NP_001166935.1	kinesin-like protein KIF21A isoform 1
NM_001173465.2	NP_001166936.1	kinesin-like protein KIF21A isoform 4
NM_001378439.1	NP_001365368.1	kinesin-like protein KIF21A isoform 5
NM_001378440.1	NP_001365369.1	kinesin-like protein KIF21A isoform 6
NM_001378441.1	NP_001365370.1	kinesin-like protein KIF21A isoform 7
NM_017641.4	NP_060111.2	kinesin-like protein KIF21A isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ankyrin repeat binding	IPI IPI: Inferred from physical interaction	29183992	GOA
enables plus-end-directed microtubule motor activity	IDA IDA: Inferred from direct assay	24120883	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19020088	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cortical microtubule organization	IMP IMP: Inferred from mutant phenotype	24120883	GOA
involved in regulation of axon guidance	IMP IMP: Inferred from mutant phenotype	24120883	GOA
involved in regulation of microtubule depolymerization	IMP IMP: Inferred from mutant phenotype	24120883	GOA
involved in regulation of microtubule polymerization	IMP IMP: Inferred from mutant phenotype	24120883	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in axonal growth cone	IDA IDA: Inferred from direct assay	24120883	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KIF21A Protein Structure

Kinesin

WD40

0
300
600
900
1200
1500
1674 a.a.

Protein Preferred Names	Protein Names
kinesin-like protein KIF21A	kinesin-like protein KIF2

KIF21A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KIF21A	Q7Z4S6	ARFGEF1	Homo sapiens	Q9Y6D6	Anti Bait CoIP	19020088
Intra	KIF21A	Q7Z4S6	ARFGEF1	Homo sapiens	Q9Y6D6	GMS	19020088
Intra	KIF21A	Q7Z4S6	ARFGEF1	Homo sapiens	Q9Y6D6	Anti Tag CoIP	22084092
Intra	KIF21A	Q7Z4S6	KANK1	Homo sapiens	Q14678	Anti Tag CoIP	26496610
Intra	KIF21A	Q7Z4S6	KANK1	Homo sapiens	Q14678	Anti Bait CoIP	19559006
Intra	KIF21A	Q7Z4S6	KANK1	Homo sapiens	Q14678	Pull Down	19559006
Intra	KIF21A	Q7Z4S6	KANK1	Homo sapiens	Q14678	Anti Tag CoIP	22084092

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Fibrosis Of Extraocular Muscles, Congenital, 1	Fibrosis Of Extraocular Muscles, Congenital, 3b CFEOM1 Blepharoptosis With Absent Eye Movements Congenital Fibrosis Of The Extraocular Muscles 1 Congenital Fibrosis Of Extraocular Muscles Type 1 Fibrosis Ophthalmoplegia, Congenital Feom1 Locus Congenital Ophthalmoplegia Feom1 CFEOM3B Fibrosis, Extraocular Muscles, Congenital, Type 1 Congenital Fibrosis Of The Extraocular Muscles
Congenital Fibrosis Of The Extraocular Muscles	Congenital Fibrosis Of Extraocular Muscles Cfeom Feom Congenital External Ophthalmoplegia Congenital Fibrosis Syndrome General Fibrosis Syndrome
Ocular Motility Disease	Ocular Motility Disorders Abnormality Of Eye Movement Disorder Of Eye Movements Eye Movement Disorder Eye Movement Disorders
Fibrosis Of Extraocular Muscles, Congenital, 2	CFEOM2 Feom2 Locus Fibrosis Of Extraocular Muscles, Congenital, Autosomal Recessive Congenital Fibrosis Of The Extraocular Muscles 2 Congenital Fibrosis Of Extraocular Muscles Autosomal Recessive Exotropic Strabismus Fixus Feom2 Fibrosis, Extraocular Muscles, Congenital, Type 2
Hypotropia
Paralytic Squint	Paralytic Strabismus Incomitant Dissociation
Hypertropia
Tukel Syndrome	Cfeom-U Congenital Fibrosis Of The Extraocular Muscles 4 Fibrosis Of Extraocular Muscles, Congenital, With Ulnar Hand Anomalies Fibrosis Of Extraocular Muscles, Congenital, 4 Cfeom4 Congenital Extraocular Muscle Fibrosis With Ulnar Hand Anomalies Congenital Fibrosis Of The Extraocular Muscles
Third Cranial Nerve Disease	Disorder Of Oculomotor Nerve Oculomotor Nerve Disorder Oculomotor Nerve Paralysis Third Cranial Nerve Disorder
Myotonic Cataract
Microphthalmia, Isolated 5	Isolated Microphthalmia 5 MCOP5 Microphthalmia, Posterior, With Retinitis Pigmentosa, Foveoschisis, And Optic Disc Drusen Microphthalmia-Retinitis Pigmentosa-Foveoschisis-Optic Disc Drusen Syndrome Posterior Microphthalmia With Retinitis Pigmentosa, Foveoschisis And Optic Disc Drusen Nanophthalmos-Retinitis Pigmentosa-Foveoschisis-Optic Disc Drusen Syndrome Microphthalmia, Isolated, 5 Microphthalmia Mfrp-Related Posterior Microphthalmia With Retinitis Pigmentosa, Foveoschisis And Optic Disk Drusen Microphthalmia, Isolated, Type 5
Exotropia	Divergent Concomitant Strabismus Divergent Strabismus Divergent Squint External Strabismus Xt - [Exotropia]
Congenital Ptosis	Congenital Blepharoptosis Congenital Eyelid Ptosis
Ptosis	Blepharoptosis Drooping Eyelid Droopy Eyelid Ptosis Of Eyelid Paralysis Of Levator Palpebrae Superioris
Strabismus	Strabismus, Susceptibility To Strabismus, Susceptibility To, 1 Strabismus 1
Marcus Gunn Phenomenon	Jaw-Winking Syndrome Marcus-Gunn Syndrome Jaw-Winking Maxillopalpebral Synkinesis Abnormal Innervation Syndrome Of Eyelid Jaw-Blinking Pterygoid-Levator Synkinesis Familial Marcus Gunn Phenomenon Marcus Gunn Syndrome Mandibulo-Palpebral Synkinesis-Ptosis Syndrome Marcus-Gunn Phenomenon
Kearns-Sayre Syndrome	Ophthalmoplegia Mitochondrial Cytopathy KSS Ophthalmoplegia, Pigmentary Degeneration Of Retina, And Cardiomyopathy Oculocraniosomatic Syndrome Chronic Progressive External Ophthalmoplegia With Myopathy Cpeo With Myopathy Total Ophthalmoplegia Ophthalmoplegia-Plus Syndrome Ophthalmoplegia, Progressive External, With Ragged-Red Fibers Cpeo With Ragged-Red Fibers Oculomotor Paralysis Renal Tubulopathy, Diabetes Mellitus, And Cerebellar Ataxia Due To Duplication O Renal Tubulopathy, Diabetes Mellitus, And Cerebellar Ataxia Due To Duplication Of Mitochondrial Dna Proximal Tubulopathy, Diabetes Mellitus And Cerebellar Ataxia Cpeo With Ragged Red Fibers Ophthalmoplegia Plus Syndrome Ophthalmoplegia, Progressive External, With Ragged Red Fibers Kearns-Sayre Mitochondrial Cytopathy Mitochondrial Myopathies
Partial Third-Nerve Palsy	Partial Third Nerve Palsy Third Nerve Palsy With Pupil Sparing Third Or Oculomotor Nerve Palsy, Partial Oculomotor Nerve Diseases Oculomotor Nerve Paralysis
Cranial Nerve Disease	Cranial Nerve Disorder Disorder Of Cranial Nerve Cranial Nerve Diseases
Abnormal Retinal Correspondence
Duane Retraction Syndrome	Stilling-Turk-Duane Syndrome Duane'S Syndrome Duane Syndrome Isolated Duane Retraction Syndrome Co-Contractive Retraction Syndrome Duane Anomaly, Isolated Ocular Retraction Syndrome Drs Durs
Duane-Radial Ray Syndrome	Okihiro Syndrome DRRS Dr Syndrome Duane Anomaly With Radial Ray Abnormalities And Deafness Acrorenoocular Syndrome Acrorenocular Syndrome Duane Anomaly With Radial Abnormalities And Deafness Acro-Renal-Ocular Syndrome
Moebius Syndrome	Mobius Syndrome Moebius Sequence Oromandibular-Limb Hypogenesis Spectrum Congenital Facial Diplegia MBS Moebius Congenital Oculofacial Paralysis Absence Or Underdevelopment Of The 6th And 7th Cranial Nerves Congenital Facial Diplegia Syndrome Congenital Oculofacial Paralysis Congenital Ophthalmoplegia And Facial Paresis Moebius Spectrum Möbius Sequence Möbius Syndrome Mobius Ii Syndrome
Esotropia	Convergence In Manifest Squint Crossed Eyes Internal Strabismus Convergent Concomitant Strabismus Convergent Squint Convergent Strabismus Cross-Eye
Fourth Cranial Nerve Palsy	Fourth Nerve Palsy Fourth Cranial Nerve Paresis Fourth Or Trochlear Nerve Palsy 4th Nerve Palsy Fourth Cranial Nerve Paralysis Superior Oblique Palsy Trochlear Nerve Palsy Trochlear Nerve Paralysis Trochlear Nerve Weakness Isolated Trochlear Nerve Palsy Atrophy Of Fourth Cranial Nerve Atrophy Of Trochlear Nerve
Rippling Muscle Disease 2	Rippling Muscle Disease Rmd Lgmd1c RMD2 Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1c Muscular Dystrophy, Limb-Girdle, Type 1c Muscular Dystrophy, Limb-Girdle, Type 1c, Formerly Lgmd1c, Formerly Limb-Girdle Muscular Dystrophy Type 1c Limb-Girdle Muscular Dystrophy Due To Caveolin-3 Deficiency Muscular Dystrophy, Limb-Girdle, Type Ic Rippling Muscle Syndrome Limb-Girdle Muscular Dystrophy 1c Dystrophy, Muscular, Limb-Girdle, Type 1c Disease, Muscle, Rippling, Type 2 Rippling Muscle Disease 1
Optic Nerve Hypoplasia, Bilateral	Optic Nerve Hypoplasia Bilateral Optic Nerve Hypoplasia Optic Nerve Hypoplasia, Familial Bilateral Familial Bilateral Optic Nerve Hypoplasia Isolated Optic Nerve Hypoplasia/Aplasia Optic Nerve Aplasia, Bilateral Onh BONH Bilateral Optic Nerve Aplasia Hypoplasia, Optic Nerve, Bilateral
Amblyopia	Lazy Eye
Keratitis, Hereditary	Keratitis Autosomal Dominant Keratitis Hereditary Keratitis Dominantly Inherited Keratitis Keratitis Hereditary KERH
Refractive Error	Refractive Errors
Facial Nerve Disease	Facial Nerve Disorder Facial Nerve Diseases Neuropathy Of Facial Nerve Disorders Of 7th Cranial Nerve Disorders Of The Seventh Cranial Nerve
Distal Arthrogryposis	Arthrogryposis Multiplex Congenita Arthrogryposis Congenital Multiple Arthrogryposis Congenital Arthromyodysplasia Fibrous Ankylosis Of Multiple Joints Guerin-Stern Syndrome Guérin-Stern Syndrome Myodystrophia Fetalis Deformans Otto Syndrome Rocher-Sheldon Syndrome Rossi Syndrome Amc Multiple Congenital Arthrogryposis Arthrogryposis Syndrome Arthrogryposis, Distal Distal Arthrogryposis Syndrome Freeman-Sheldon Syndrome Arthrogryposis, Distal, Type 2b Congenital Multiplex Arthrogryposis Amyoplasia Congenita Congenital Amyoplasia Amc - [Arthrogryposis Multiplex Congenita]
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07274	KIF21A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21877	Kif21a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28394	Kif21a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	KIF21A	MGD	MGI:109188
Canis familiaris	KIF21A	VGNC	VGNC:42396
Bos taurus	KIF21A	VGNC	VGNC:30595
Rattus norvegicus	KIF21A	RGD	RGD:1305126
Macaca mulatta	KIF21A	VGNC	VGNC:73861
Felis catus	KIF21A	VGNC	VGNC:63112
Others	KIF21A	NCBI