KDM4D - lysine demethylase 4D Gene

Also Known as JMJD2D

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55693

About KDM4D

Cytogenetic location: 11q21 Genomic coordinates (GRCh38): 11:94,973,709-94,999,519 (from NCBI)

This gene has 3 transcripts (splice variants), 207 orthologues and 10 paralogues. Biased expression in testis (RPKM 26.3) and brain (RPKM 0.6).

Summary

Enables histone H3-methyl-lysine-9 demethylase activity. Involved in histone H3-K9 demethylation. Acts upstream of or within several processes, including cellular response to ionizing radiation; positive regulation of chromatin binding activity; and positive regulation of double-strand break repair via nonhomologous end joining. Located in site of double-strand break. Biomarker of nephroblastoma. [provided by Alliance of Genome Resources, Apr 2022]

KDM4D Products (1)

mRNA Protein Name
NM_018039.3 NP_060509.2 lysine-specific demethylase 4D

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables histone H3K9 demethylase activity IDA
IDA: Inferred from direct assay
25124442 GOA
enables histone H3K9me2/H3K9me3 demethylase activity IDA
IDA: Inferred from direct assay
21914792 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to ionizing radiation IMP
IMP: Inferred from mutant phenotype
24550317 GOA
acts upstream of or within double-strand break repair via homologous recombination IMP
IMP: Inferred from mutant phenotype
24550317 GOA
involved in inflammatory response IDA
IDA: Inferred from direct assay
21914792 GOA
acts upstream of or within positive regulation of chromatin binding IMP
IMP: Inferred from mutant phenotype
24550317 GOA
acts upstream of or within positive regulation of double-strand break repair via nonhomologous end joining IMP
IMP: Inferred from mutant phenotype
24550317 GOA
acts upstream of or within regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
24550317 GOA
Cellular Component GO Annotation Evidence References Source
located in site of double-strand break IDA
IDA: Inferred from direct assay
24550317 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KDM4D Protein Structure

JmjN

JmjN: jmjN domain (19 - 53)

JmjC

JmjC: JmjC domain, hydroxylase (179 - 295)

  • 0
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  • 400
  • 500
  • 523 a.a.
Protein Preferred Names Protein Names

lysine-specific demethylase 4D

  • [histone H3]-trimethyl-L-lysine(9) demethylase 4D

KDM4D Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
KDM4D Q6B0I6 CEP76 Homo sapiens Q8TAP6
Y2H Prey Pooling
32296183
Intra
KDM4D Q6B0I6 CEP76 Homo sapiens Q8TAP6
Validated Y2H
32296183
Intra
KDM4D Q6B0I6 CEP76 Homo sapiens Q8TAP6
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-104048 QC6352 Inhibitor 99.13% Unkown
HY-148807 Zavondemstat 99.29% Unkown
HY-101928 KDM4D-IN-1 Inhibitor 98.82% Unkown
HY-148807B (S)-Zavondemstat Control 97.51% Unkown
HY-RS07216 KDM4D Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-173135 PROTAC KDM4 degrader-1 / Unkown
HY-157408 KDM4D-IN-3 / Unkown
HY-RS20046 Kdm4d Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26549 Kdm4d Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus KDM4D MGD MGI:3606484
Rattus norvegicus KDM4D RGD RGD:1591045
Macaca mulatta KDM4D VGNC VGNC:73908
Others KDM4D NCBI