2. Gene
  3. KDM4D - lysine demethylase 4D Gene

KDM4D - lysine demethylase 4D Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as JMJD2D

Gene ID: 55693 | Gene type: protein coding

About KDM4D

Cytogenetic location: 11q21 Genomic coordinates (GRCh38): 11:94,973,709-94,999,519 (from NCBI)

This gene has 3 transcripts (splice variants), 207 orthologues and 10 paralogues. Biased expression in testis (RPKM 26.3) and brain (RPKM 0.6).

Summary

Enables histone H3-methyl-lysine-9 demethylase activity. Involved in histone H3-K9 demethylation. Acts upstream of or within several processes, including cellular response to ionizing radiation; positive regulation of chromatin binding activity; and positive regulation of double-strand break repair via nonhomologous end joining. Located in site of double-strand break. Biomarker of nephroblastoma. [provided by Alliance of Genome Resources, Apr 2022]

KDM4D Products(1)

mRNA Protein Name
NM_018039.3 NP_060509.2 lysine-specific demethylase 4D

KDM4D Protein Structure

JmjN

JmjN: jmjN domain (19 - 53)

JmjC

JmjC: JmjC domain, hydroxylase (179 - 295)

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  • 523 a.a.
Protein Preferred Names Protein Names

lysine-specific demethylase 4D

[histone H3]-trimethyl-L-lysine(9) demethylase 4D

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-104048 QC6352 Inhibitor 99.48% Unkown
HY-101928 KDM4D-IN-1 Inhibitor 99.95% Unkown
HY-148807 Zavondemstat Inhibitor / Unkown
HY-148807A Zavondemstat L-lysine Inhibitor / Unkown
HY-RS07216 KDM4D Human Pre-designed siRNA Set A / Unkown
HY-157408 KDM4D-IN-3 / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus KDM4D MGD MGI:3606484
Rattus norvegicus KDM4D RGD RGD:1591045
Macaca mulatta KDM4D VGNC VGNC:73908
Others KDM4D NCBI