CMTR2 - cap methyltransferase 2 Gene

Also Known as AFT; MTr2; HMTr2; FTSJD1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55783

About CMTR2

Cytogenetic location: 16q22.2 Genomic coordinates (GRCh38): 16:71,281,392-71,289,722 (from NCBI)

This gene has 8 transcripts (splice variants), 179 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 7.6), testis (RPKM 6.7) and 25 other tissues.

Summary

Enables mRNA (nucleoside-2'-O-)-methyltransferase activity. Involved in 7-methylguanosine mRNA capping and cap2 mRNA methylation. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

CMTR2 Products (6)

mRNA Protein Name
NM_001099642.2 NP_001093112.1 cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2
NM_001324374.2 NP_001311303.1 cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2
NM_001324377.2 NP_001311306.1 cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2
NM_001324378.2 NP_001311307.1 cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2
NM_001324379.2 NP_001311308.1 cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2
NM_018348.6 NP_060818.4 cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables mRNA (nucleoside-2'-O-)-methyltransferase activity IDA
IDA: Inferred from direct assay
21310715 GOA
Biological Process GO Annotation Evidence References Source
involved in 7-methylguanosine mRNA capping IDA
IDA: Inferred from direct assay
21310715 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
21310715 GOA
located in nucleus IDA
IDA: Inferred from direct assay
21310715 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CMTR2 Protein Structure

FtsJ

FtsJ: FtsJ-like methyltransferase (113 - 319)

  • 0
  • 200
  • 400
  • 600
  • 770 a.a.
Protein Preferred Names Protein Names

cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2

  • FtsJ methyltransferase domain containing 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02872 CMTR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-184488 AT-1965 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CMTR2 RGD RGD:1309394
Mus musculus CMTR2 MGD MGI:2384580
Macaca mulatta CMTR2 VGNC VGNC:71350
Canis familiaris CMTR2 VGNC VGNC:39386
Bos taurus CMTR2 VGNC VGNC:27490
Felis catus CMTR2 VGNC VGNC:61005
Others CMTR2 NCBI