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MESP1 - mesoderm posterior bHLH transcription factor 1 Gene

Also Known as bHLHc5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55897

About MESP1

Cytogenetic location: 15q26.1 Genomic coordinates (GRCh38): 15:89,732,446-89,751,249 (from NCBI)

This gene has 2 transcripts (splice variants), 276 orthologues and 2 paralogues. Biased expression in fat (RPKM 4.6), prostate (RPKM 4.1) and 4 other tissues.

Summary

Enables DNA-binding transcription factor activity and transcription cis-regulatory region binding activity. Involved in several processes, including endothelial cell differentiation; heart development; and positive regulation of transcription by RNA polymerase II. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

MESP1 Products (1)

mRNA	Protein	Name
NM_018670.4	NP_061140.1	mesoderm posterior protein 1

MESP1 Protein Structure

HLH

0
100
200
268 a.a.

Protein Preferred Names	Protein Names
mesoderm posterior protein 1	class C basic helix-loop-helix protein 5

MESP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MESP1	Q9BRJ9	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	MESP1	Q9BRJ9	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	MESP1	Q9BRJ9	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

MESP1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P85278	MESP1 Antibody (YA4970)	WB, ELISA	Human

Related Diseases

Diseases	Alias
Double Outlet Right Ventricle	Double Outlet Right Ventricle With Subpulmonary Ventricular Septal Defect Taussig-Bing Syndrome Dextrotransposition Of Aorta Taussig-Bing Syndrome Or Defect Dorv Dorv With Subpulmonary Vsd Dorv-Tga Double Outlet Right Ventricle With Transposition Of The Great Arteries Double Outlet Right Ventricle With Subpulmonary Interventricular Communication, Transposition Type Taussig-Bing Heart Taussig-Bing Malformation Taussig-Bing Complex Taussig-Bing Defect Taussig-Bing Double Outlet Right Ventricle With Remote Ventricular Septal Defect Double Outlet Right Ventricle With Uncommitted Ventricular Septal Defect Double Outlet Right Ventricle With Non-Committed Interventricular Communication Double Outlet Right Ventricle With Subaortic Or Doubly Committed Interventricular Communication Without Pulmonary Stenosis Double Outlet Right Ventricle With Subaortic Or Doubly Committed Interventricular Communication And Pulmonary Stenosis
Cardiomyopathy, Dilated, 1x	Dilated Cardiomyopathy 1x CMD1X Dilated Cardiomyopathy With Mild Or No Proximal Muscle Weakness Cardiomyopathy, Dilated, With Mild Or No Proximal Muscle Weakness Cardiomyopathy, Dilated 1x Cardiomyopathy, Dilated, Type 1x
Mongolian Spot	Mongolian Macula
Dysostosis	Dysostoses
Hypoplastic Left Heart Syndrome	Hlhs Heart, Hypoplastic Left, Syndrome Hypoplasia Of The Left Heart Left Heart Hypoplasia Syndrome Hlhs - [Hypoplastic Left Heart Syndrome] Hypoplasia Of Aortic Valve, In Hypoplastic Left Heart Syndrome Atresia Of Mitral Valve, In Hypoplastic Left Heart Syndrome Atresia Or Marked Hypoplasia Of Aortic Orifice Or Valve, With Hypoplasia Of Ascending Aorta And Defective Development Of Left Ventricle Atresia Or Marked Hypoplasia, Of Aortic Orifice Or Valve, With Hypoplasia Of Ascending Aorta And Defective Development Of Left Ventricle With Mitral Valve Atresia Aortic Valve Atresia, In Hypoplastic Left Heart Syndrome Ascending Aorta Hypoplasia, In Hypoplastic Left Heart Syndrome
Ventricular Septal Defect	Ventricular Septal Defects Interventricular Septal Defect Heart Septal Defects, Ventricular Ventricular Septal Abnormality Interventricular Septum Defect Ventricular Septum Defect Vsd - [Ventricular Septum Defect] Congenital Ventricular Septal Defect Single Ventricular Septal Defect
Tetralogy Of Fallot	TOF Fallot Tetralogy Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle Tetrad Of Fallot Fallot Tetrad Fallot Disease Fallot Complex Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle Interventricular Septal Defect, In Tetralogy Of Fallot Ventricular Septal Defect With Obstructed Right Ventricular Outflow Tof - [Tetralogy Of Fallot] Pulmonary Atresia With Ventricular Septal Defect [Fallot Type] Pulmonary Atresia, Ventricular Septal Defect And Mapcas Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08342	MESP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174582	Human MESP1 mRNA		/	Unkown
HY-RS20447	Mesp1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26956	Mesp1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MESP1	VGNC	VGNC:63453
Macaca mulatta	MESP1	VGNC	VGNC:74618
Canis familiaris	MESP1	VGNC	VGNC:43163
Mus musculus	MESP1	MGD	MGI:107785
Rattus norvegicus	MESP1	RGD	RGD:1311751
Bos taurus	MESP1	VGNC	VGNC:106820
Others	MESP1	NCBI