Aatf - apoptosis antagonizing transcription factor Gene

Also Known as Trb; Che-1; 4933415H02Rik; 5830465M17Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56321

Summary

Predicted to enable leucine zipper domain binding activity; protein kinase binding activity; and Tau Protein binding activity. Acts upstream of or within several processes, including negative regulation of amyloid precursor protein biosynthetic process; negative regulation of apoptotic signaling pathway; and regulation of mitotic cell cycle. Located in cytoplasm and nucleolus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; liver; and nervous system. Orthologous to human AATF (Apoptosis antagonizing transcription factor). [provided by Alliance of Genome Resources, Apr 2022]

Aatf Products (1)

mRNA Protein Name
NM_019816.1 NP_062790.1 protein AATF

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14627703 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of cell adhesion IMP
IMP: Inferred from mutant phenotype
11071758 MGI
acts upstream of embryonic cleavage IMP
IMP: Inferred from mutant phenotype
11071758 MGI
acts upstream of or within negative regulation of amyloid precursor protein biosynthetic process IDA
IDA: Inferred from direct assay
14627703 MGI
acts upstream of or within negative regulation of apoptotic signaling pathway IGI
IGI: Inferred from genetic interaction
17488777 MGI
acts upstream of or within regulation of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
11071758 MGI
acts upstream of or within ribosome biogenesis IMP
IMP: Inferred from mutant phenotype
11071758 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
14627703 MGI
located in nucleolus IDA
IDA: Inferred from direct assay
11071758 MGI
located in nucleus IDA
IDA: Inferred from direct assay
11071758 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
19911006 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein AATF

  • rb-binding protein Che-1

  • traube protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00034 AATF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20688 Aatf Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27199 Aatf Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aatf NCBI NCBI:26574