2. Gene
  3. Ikbke - inhibitor of kappaB kinase epsilon Gene

Ikbke - inhibitor of kappaB kinase epsilon Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Ikki; IKK-E; IKK-i; IKKepsilon

Gene ID: 56489 | Gene type: protein coding

About Ikbke

Chromosome 1: 131,182,080-131,207,344 reverse strand.GRCm39:CM000994.3

This gene has 7 transcripts (splice variants), 199 orthologues, 3 paralogues and is associated with 10 phenotypes. Broad expression in thymus adult (RPKM 2.8), large intestine adult (RPKM 16.) and 18 other tissues.

Summary

Enables IkappaB kinase activity; K48-linked polyubiquitin modification-dependent protein binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including interleukin-17-mediated signaling pathway; mRNA stabilization; and positive regulation of type I interferon-mediated signaling pathway. Predicted to be located in PML body and mitochondrial membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including future brain; sensory organ; submandibular gland primordium; thymus primordium; and turbinate bone primordium. Orthologous to human IKBKE (inhibitor of nuclear factor kappa B kinase subunit epsilon). [provided by Alliance of Genome Resources, Apr 2022]

Ikbke Products(1)

mRNA Protein Name
NM_019777.3 NP_062751.2 inhibitor of nuclear factor kappa-B kinase subunit epsilon

Ikbke Protein Structure

PKc_like

PKc_like: cl21453 (14 - 329)

Ubl_IKKE

Ubl_IKKE: cd17128 (307 - 382)

TBK1_CCD1

TBK1_CCD1: cl39732 (401 - 647)

TBK1_IKKE-like_C

TBK1_IKKE-like_C: cl41735 (669 - 715)

  • 0
  • 200
  • 400
  • 600
  • 717 a.a.
Protein Preferred Names Protein Names

inhibitor of nuclear factor kappa-B kinase subunit epsilon

I-kappa-B kinase epsilon

IKK-epsilon

inducible I kappa-B kinase

inducible IKappaB kinase

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-D0162 Malachite green hemioxalate ≥98.0% Unkown
HY-RS06661 IKBKE Human Pre-designed siRNA Set A / Unkown
HY-RS06662 Ikbke Mouse Pre-designed siRNA Set A / Unkown
HY-RS06663 Ikbke Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ikbke NCBI NCBI:9641