Ikbke - inhibitor of kappaB kinase epsilon Gene

Also Known as Ikki; IKK-E; IKK-i; IKKepsilon

Species: Mus musculus

Gene Type: protein coding

Gene ID: 56489

About Ikbke

Chromosome 1: 131,182,080-131,207,344 reverse strand.GRCm39:CM000994.3

This gene has 7 transcripts (splice variants), 199 orthologues, 3 paralogues and is associated with 10 phenotypes. Broad expression in thymus adult (RPKM 2.8), large intestine adult (RPKM 16.) and 18 other tissues.

Summary

Enables IkappaB kinase activity; K48-linked polyubiquitin modification-dependent protein binding activity; and ubiquitin protein Ligase binding activity. Involved in several processes, including interleukin-17-mediated signaling pathway; mRNA stabilization; and positive regulation of type I interferon-mediated signaling pathway. Predicted to be located in PML body and mitochondrial membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including future brain; sensory organ; submandibular gland primordium; thymus primordium; and turbinate bone primordium. Orthologous to human IKBKE (inhibitor of nuclear factor kappa B kinase subunit epsilon). [provided by Alliance of Genome Resources, Apr 2022]

Ikbke Products (1)

mRNA	Protein	Name
NM_019777.3	NP_062751.2	inhibitor of nuclear factor kappa-B kinase subunit epsilon

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables IkappaB kinase activity	IDA IDA: Inferred from direct assay	10421793	MGI
enables K48-linked polyubiquitin modification-dependent protein binding	IDA IDA: Inferred from direct assay	24882218	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	21822257	MGI
enables protein kinase activity	IDA IDA: Inferred from direct assay	21822257	MGI
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	24882218	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to virus	IDA IDA: Inferred from direct assay	24882218	MGI
involved in gene expression	IMP IMP: Inferred from mutant phenotype	21822257	MGI
involved in immune response	IMP IMP: Inferred from mutant phenotype	21822257	MGI
involved in interleukin-17-mediated signaling pathway	IDA IDA: Inferred from direct assay	21822257	MGI
involved in mRNA stabilization	IMP IMP: Inferred from mutant phenotype	21822257	MGI
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	21822257	MGI
involved in positive regulation of lipid storage	IMP IMP: Inferred from mutant phenotype	23741427	MGI
involved in positive regulation of type I interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	27129230	MGI
involved in regulation of protein-containing complex assembly	IMP IMP: Inferred from mutant phenotype	21822257	MGI
involved in response to type I interferon	IDA IDA: Inferred from direct assay	24882218	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ikbke Protein Structure

PKc_like

Ubl_IKKE

TBK1_CCD1

TBK1_IKKE-like_C

0
200
400
600
717 a.a.

Protein Preferred Names	Protein Names
inhibitor of nuclear factor kappa-B kinase subunit epsilon	I-kappa-B kinase epsilon IKK-epsilon inducible I kappa-B kinase inducible IKappaB kinase inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon

Ikbke Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Ikbke	Q9R0T8	Traf3ip2	Mus musculus	Q8N7N6	Anti Bait CoIP	21822257

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-D0162	Malachite green hemioxalate		98.0%	Unkown
HY-RS06661	IKBKE Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06662	Ikbke Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06663	Ikbke Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ikbke	NCBI	NCBI:9641