Vapb - vesicle-associated membrane protein, associated protein B and C Gene

Also Known as VAP-B; VAMP-B; VAP33b; D2Abb2e; Vamp33b

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56491

Summary

Predicted to enable several functions, including FFAT motif binding activity; protein dimerization activity; and tubulin binding activity. Predicted to be involved in several processes, including IRE1-mediated unfolded protein response; endoplasmic reticulum organization; and modulation by host of viral genome replication. Predicted to act upstream of or within response to unfolded protein. Located in membrane. Is expressed in dorsal root ganglion. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 8; autosomal dominant adult-onset proximal spinal muscular atrophy; and spinal muscular atrophy. Orthologous to human VAPB (VAMP associated protein B and C). [provided by Alliance of Genome Resources, Apr 2022]

Vapb Products (1)

mRNA Protein Name
NM_019806.6 NP_062780.2 vesicle-associated membrane protein-associated protein B

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
24251978 MGI
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
14561759 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

vesicle-associated membrane protein-associated protein B

  • VAMP-associated protein 33b

  • VAMP-associated protein B

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15603 VAPB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18156 Vapb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24630 Vapb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vapb NCBI NCBI:9217