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AZU1 - azurocidin 1 Gene

Also Known as AZU; HBP; NAZC; hHBP; AZAMP; CAP37; HUMAZUR

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 566

About AZU1

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:827,837-832,018 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 238 orthologues and 6 paralogues. Restricted expression toward bone marrow (RPKM 1256.4).

Summary

Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of Microorganisms. This gene encodes a preproprotein that is proteolytically processed to generate a mature azurophil granule Antibiotic protein, with monocyte chemotactic and antimicrobial activity. It is also an important multifunctional inflammatory mediator. This encoded protein is a member of the serine protease gene family but it is not a serine proteinase, because the active site serine and histidine residues are replaced. The genes encoding this protein, neutrophil Elastase 2, and proteinase 3 are in a cluster located at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, Nov 2015]

AZU1 Products (1)

mRNA	Protein	Name
NM_001700.5	NP_001691.1	azurocidin preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables heparan sulfate proteoglycan binding	IDA IDA: Inferred from direct assay	15879141	GOA
enables heparin binding	IMP IMP: Inferred from mutant phenotype	11994286	GOA
enables peptidase activity	IDA IDA: Inferred from direct assay	21550830	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11994286	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in antimicrobial humoral response	IMP IMP: Inferred from mutant phenotype	11994286	GOA
involved in cell chemotaxis	IMP IMP: Inferred from mutant phenotype	24008408	GOA
involved in defense response to virus	IMP IMP: Inferred from mutant phenotype	19274533	GOA
involved in glial cell migration	IDA IDA: Inferred from direct assay	12465046	GOA
involved in intracellular signal transduction	IMP IMP: Inferred from mutant phenotype	24008408	GOA
involved in microglial cell activation	IEP IEP: Inferred from expression pattern	12465046	GOA
involved in monocyte extravasation	IDA IDA: Inferred from direct assay	15879141	GOA
involved in neutrophil-mediated killing of bacterium	IDA IDA: Inferred from direct assay	2312733	GOA
involved in positive regulation of MHC class II biosynthetic process	IEP IEP: Inferred from expression pattern	12465046	GOA
involved in positive regulation of cell adhesion	IDA IDA: Inferred from direct assay	12826073	GOA
involved in positive regulation of fractalkine production	IDA IDA: Inferred from direct assay	12465046	GOA
involved in positive regulation of interleukin-1 beta production	IDA IDA: Inferred from direct assay	12465046	GOA
involved in positive regulation of phagocytosis	IDA IDA: Inferred from direct assay	12465046	GOA
involved in positive regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	12465046	GOA
involved in proteolysis	IDA IDA: Inferred from direct assay	21550830	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in azurophil granule	IDA IDA: Inferred from direct assay	11861296	GOA
located in azurophil granule membrane	IDA IDA: Inferred from direct assay	2312733	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	15879141	GOA
located in membrane	IDA IDA: Inferred from direct assay	2312733	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AZU1 Protein Structure

Trypsin

0
100
200
251 a.a.

Protein Preferred Names	Protein Names
azurocidin	cationic antimicrobial protein 37

Recombinant AZU1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7624	Azurocidin Protein, Human (HEK293, His)	P20160 (I27-P250)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Erysipelas
Camptodactyly-Arthropathy-Coxa Vara-Pericarditis Syndrome	Jacobs Syndrome Arthropathy-Camptodactyly Syndrome Pericarditis-Arthropathy-Camptodactyly Syndrome Xyy Syndrome Pac Syndrome Cacp Syndrome CACP Fibrosing Serositis, Familial Camptodactyly-Arthropathy-Pericarditis Syndrome Cap Syndrome 47, Xyy Syndrome 47,Xyy Syndrome Double Y Syndrome Camptodactyly-Arthropathy-Coxa-Vara-Pericarditis Syndrome Hypertrophic Synovitis, Congenital Familial Congenital Familial Hypertrophic Synovitis Xyy Karyotype Y Disomy Yy Syndrome Familial Fibrosing Serositis Disomy Y Double Y Camptodactyly Arthropathy Coxa Vara Pericarditis Syndrome Arthropathy Camptodactyly Syndrome Camptodactyly Arthropathy Pericarditis Syndrome Pericarditis Arthropathy Camptodactyly Syndrome Jacob'S Syndrome 47,Xyy Cdags Syndrome
Dacryocystitis	Nasolacrimal Sac Infection
Acute Inflammation Of Lacrimal Passage
Cornea Cancer	Malignant Neoplasm Of Cornea Neoplasm Of Cornea Corneal Tumor Malignant Corneal Tumor Malignant Tumor Of Cornea Primary Malignant Neoplasm Of Cornea
Congenital Disorder Of Glycosylation, Type Ig	CDG1G Alg12-Congenital Disorder Of Glycosylation Cdg Ig Congenital Disorder Of Glycosylation Type 1g Congenital Disorder Of Glycosylation Type Ig Cdgig Congenital Disorder Of Glycosylation Ig Congenital Disorder Of Glycosylation 1g Cdg-Ig Alg12-Cdg Cdg Syndrome Type Ig Carbohydrate Deficient Glycoprotein Syndrome Type Ig Mannosyltransferase 8 Deficiency Glycosylation, Congenital Disorder Of, Type Ig
Hepatic Veno-Occlusive Disease	Veno-Occlusive Disease Sinusoidal Obstruction Syndrome Hepatic Venoocclusive Disease Venoocclusive Disease Hepatic Vein Thrombosis Budd-Chiari Syndrome Hepatic Vein Occlusion Veno-Occlusive Disease Of The Liver
Viral Meningitis	Meningitis Viral Meningitis, Viral Viral Meningitis Nec
Pericarditis
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Necrotizing Fasciitis	Fasciitis, Necrotizing

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01298	AZU1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14140	TACC2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown