AZU1 - azurocidin 1 Gene

Homo sapiens

Also known as AZU; HBP; NAZC; hHBP; AZAMP; CAP37; HUMAZUR

Gene ID: 566 | Gene type: protein coding

About AZU1

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:827,837-832,018 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 238 orthologues and 6 paralogues. Restricted expression toward bone marrow (RPKM 1256.4).

Summary

Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of Microorganisms. This gene encodes a preproprotein that is proteolytically processed to generate a mature azurophil granule Antibiotic protein, with monocyte chemotactic and antimicrobial activity. It is also an important multifunctional inflammatory mediator. This encoded protein is a member of the serine protease gene family but it is not a serine proteinase, because the active site serine and histidine residues are replaced. The genes encoding this protein, neutrophil Elastase 2, and proteinase 3 are in a cluster located at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, Nov 2015]

AZU1 Products(1)

mRNA	Protein	Name
NM_001700.5	NP_001691.1	azurocidin preproprotein

AZU1 Protein Structure

Trypsin

0
100
200
251 a.a.

Protein Preferred Names

Protein Names

azurocidin

cationic antimicrobial protein 37

Recombinant AZU1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7624	Azurocidin Protein, Human (HEK293, His)	P20160 (I27-P250)	≥95%

Related Diseases

Diseases

Alias

Erysipelas

Camptodactyly-Arthropathy-Coxa Vara-Pericarditis Syndrome

Jacobs Syndrome	Arthropathy-Camptodactyly Syndrome
Pericarditis-Arthropathy-Camptodactyly Syndrome	Xyy Syndrome
Pac Syndrome	Cacp Syndrome
CACP	Fibrosing Serositis, Familial
Camptodactyly-Arthropathy-Pericarditis Syndrome	Cap Syndrome
47, Xyy Syndrome	47,Xyy Syndrome
Double Y Syndrome	Camptodactyly-Arthropathy-Coxa-Vara-Pericarditis Syndrome
Hypertrophic Synovitis, Congenital Familial	Congenital Familial Hypertrophic Synovitis
Xyy Karyotype	Y Disomy
Yy Syndrome	Familial Fibrosing Serositis
Disomy Y	Double Y
Camptodactyly Arthropathy Coxa Vara Pericarditis Syndrome	Arthropathy Camptodactyly Syndrome
Camptodactyly Arthropathy Pericarditis Syndrome	Pericarditis Arthropathy Camptodactyly Syndrome
Jacob'S Syndrome	47,Xyy
Cdags Syndrome

Dacryocystitis

Nasolacrimal Sac Infection

Acute Inflammation Of Lacrimal Passage

Cornea Cancer

Malignant Neoplasm Of Cornea	Neoplasm Of Cornea
Corneal Tumor	Malignant Corneal Tumor
Malignant Tumor Of Cornea	Primary Malignant Neoplasm Of Cornea

Congenital Disorder Of Glycosylation, Type Ig

CDG1G	Alg12-Congenital Disorder Of Glycosylation
Cdg Ig	Congenital Disorder Of Glycosylation Type 1g
Congenital Disorder Of Glycosylation Type Ig	Cdgig
Congenital Disorder Of Glycosylation Ig	Congenital Disorder Of Glycosylation 1g
Cdg-Ig	Alg12-Cdg
Cdg Syndrome Type Ig	Carbohydrate Deficient Glycoprotein Syndrome Type Ig
Mannosyltransferase 8 Deficiency	Glycosylation, Congenital Disorder Of, Type Ig

Hepatic Veno-Occlusive Disease

Veno-Occlusive Disease	Sinusoidal Obstruction Syndrome
Hepatic Venoocclusive Disease	Venoocclusive Disease
Hepatic Vein Thrombosis	Budd-Chiari Syndrome
Hepatic Vein Occlusion	Veno-Occlusive Disease Of The Liver

Viral Meningitis

Meningitis Viral	Meningitis, Viral
Viral Meningitis Nec

Pericarditis

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Necrotizing Fasciitis

Fasciitis, Necrotizing