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Prkn - parkin RBR E3 ubiquitin protein ligase Gene

Also Known as Park; Park2

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 56816

Summary

Enables protein kinase binding activity. Involved in several processes, including cellular response to amino acid stimulus; negative regulation of neuron death; and negative regulation of synaptic transmission. Acts upstream of or within negative regulation of neuron death. Located in several cellular components, including bounding membrane of organelle; membrane raft; and postsynaptic density. Colocalizes with mitochondrion. Used to study Parkinson's disease. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 2; and ovarian Cancer. Orthologous to human PRKN (parkin RBR E3 ubiquitin protein Ligase). [provided by Alliance of Genome Resources, Apr 2022]

Prkn Products (1)

mRNA	Protein	Name
NM_020093.1	NP_064478.1	E3 ubiquitin-protein ligase parkin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16332688	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	28608965	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	12716939	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to L-glutamate	IDA IDA: Inferred from direct assay	25478815	RGD
involved in cellular response to L-glutamine	IEP IEP: Inferred from expression pattern	28761318	RGD
involved in cellular response to hydrogen sulfide	IDA IDA: Inferred from direct assay	28608965	RGD
involved in cellular response to manganese ion	IEP IEP: Inferred from expression pattern	19781568	RGD
involved in cellular response to oxidative stress	IMP IMP: Inferred from mutant phenotype	23392669	RGD
involved in mitochondrial fragmentation involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	28761318	RGD
involved in mitochondrion localization	IDA IDA: Inferred from direct assay	20457763	RGD
involved in mitophagy	IDA IDA: Inferred from direct assay	20457763	RGD
involved in negative regulation of excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	19033459	RGD
involved in negative regulation of mitochondrial fission	IMP IMP: Inferred from mutant phenotype	24096089	RGD
acts upstream of or within negative regulation of neuron apoptotic process	IGI IGI: Inferred from genetic interaction	20823226	RGD
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	28761318	RGD
involved in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	23392669	RGD
involved in negative regulation of reactive oxygen species biosynthetic process	IMP IMP: Inferred from mutant phenotype	24096089	RGD
involved in negative regulation of synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	19033459	RGD
involved in positive regulation of ATP biosynthetic process	IMP IMP: Inferred from mutant phenotype	24096089	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	28673964	RGD
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	24096089	RGD
involved in positive regulation of mitochondrial membrane potential	IMP IMP: Inferred from mutant phenotype	24096089	RGD
involved in positive regulation of mitophagy	IMP IMP: Inferred from mutant phenotype	28608965	RGD
involved in protein localization to mitochondrion	IDA IDA: Inferred from direct assay	20457763	RGD
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	20457763	RGD
involved in regulation of postsynaptic membrane neurotransmitter receptor levels	IDA IDA: Inferred from direct assay	25316086	RGD
involved in regulation of postsynaptic membrane neurotransmitter receptor levels	IEP IEP: Inferred from expression pattern	25316086	RGD
involved in regulation of postsynaptic membrane neurotransmitter receptor levels	IMP IMP: Inferred from mutant phenotype	25316086	RGD
involved in response to corticosterone	IEP IEP: Inferred from expression pattern	14663185	RGD
involved in response to curcumin	IEP IEP: Inferred from expression pattern	28698153	RGD
involved in response to endoplasmic reticulum stress	IEP IEP: Inferred from expression pattern	12415119	RGD
involved in response to muscle activity	IEP IEP: Inferred from expression pattern	26678157	RGD
involved in response to unfolded protein	IEP IEP: Inferred from expression pattern	12472897	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	12618056	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi membrane	IDA IDA: Inferred from direct assay	12150907	RGD
located in axon	IDA IDA: Inferred from direct assay	28761318	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	12150907	RGD
located in cytosol	IDA IDA: Inferred from direct assay	20457763	RGD
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	12150907	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	25316086	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	25316086	RGD
located in intracellular vesicle	IDA IDA: Inferred from direct assay	12472897	RGD
located in mitochondrion	IDA IDA: Inferred from direct assay	20457763	RGD
located in neuron projection	IDA IDA: Inferred from direct assay	12925569	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	12472897	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	12925569	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	15480834	RGD
is active in presynapse	IDA IDA: Inferred from direct assay	15480834	RGD
located in presynapse	IDA IDA: Inferred from direct assay	12000718	RGD
located in synapse	IDA IDA: Inferred from direct assay	12150907	RGD
located in synaptic vesicle	IDA IDA: Inferred from direct assay	15480834	RGD
is active in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	15480834	RGD
located in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	11432972	RGD
located in terminal bouton	IDA IDA: Inferred from direct assay	12925569	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase parkin	Parkinson disease (autosomal recessive, juvenile) 2, parkin parkin RBR E3 ubiquitin protein ligase 2 parkin variant SV5DEL parkinson protein 2, E3 ubiquitin protein ligase

Prkn Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Prkn	Q9JK66	Ranbp2	Rattus norvegicus	D4A054	Anti Bait CoIP	16332688

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS25456	Prkn Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11156	PRKN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18966	Prkn Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prkn	NCBI	NCBI:5071