BBX - BBX high mobility group box domain containing Gene

Homo sapiens

Also known as HBP2; ARTC1; MDS001; HSPC339

Gene ID: 56987 | Gene type: protein coding

About BBX

This gene has 26 transcripts (splice variants), 199 orthologues and 1 paralogue. Broad expression in testis (RPKM 26.5), thyroid (RPKM 14.4) and 24 other tissues.

Summary

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within bone development. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

BBX Products(3)

mRNA	Protein	Name
NM_001142568.3	NP_001136040.1	HMG box transcription factor BBX isoform 1
NM_001276286.2	NP_001263215.1	HMG box transcription factor BBX isoform 3
NM_020235.7	NP_064620.2	HMG box transcription factor BBX isoform 2

BBX Protein Structure

HMG_box

DUF2028

0
200
400
600
800
941 a.a.

Protein Preferred Names

Protein Names

HMG box transcription factor BBX

Ag recognized by Treg cells 1

Related Diseases

Diseases

Alias

Hemolytic Disease Of Fetus And Newborn, Rh-Induced

Rh Deficiency Syndrome	Rh Disease
HDFNRH	Rh Fetomaternal Incompatibility
Rh-Null Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01392	BBX Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	BBX	RGD	RGD:1309769
Felis catus	BBX	VGNC	VGNC:60076
Bos taurus	BBX	VGNC	VGNC:26433
Mus musculus	BBX	MGD	MGI:1917758
Canis familiaris	BBX	VGNC	VGNC:38394
Macaca mulatta	BBX	VGNC	VGNC:82110