CD177 - CD177 molecule Gene

Also Known as NB1; PRV1; HNA2A; PRV-1; HNA-2a; NB1 GP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 57126

About CD177

Cytogenetic location: 19q13.31 Genomic coordinates (GRCh38): 19:43,353,686-43,366,081 (from NCBI)

This gene has 3 transcripts (splice variants), 97 orthologues and 2 paralogues. Biased expression in bone marrow (RPKM 83.5), colon (RPKM 72.9) and 1 other tissue.

Summary

This gene encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Mutations in this gene are associated with myeloproliferative diseases. Over-expression of this gene has been found in patients with polycythemia rubra vera. Autoantibodies against the protein may result in pulmonary transfusion reactions, and it may be involved in Wegener's granulomatosis. A related pseudogene, which is adjacent to this gene on chromosome 19, has been identified. [provided by RefSeq, Apr 2014]

CD177 Products (1)

mRNA	Protein	Name
NM_020406.4	NP_065139.2	CD177 antigen precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium-dependent protein binding	IPI IPI: Inferred from physical interaction	17580308	GOA
enables integrin binding	IPI IPI: Inferred from physical interaction	21193407	GOA
enables protease binding	IPI IPI: Inferred from physical interaction	17244676	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell adhesion	IMP IMP: Inferred from mutant phenotype	28807980	GOA
involved in cell-cell adhesion via plasma-membrane adhesion molecules	IMP IMP: Inferred from mutant phenotype	17580308	GOA
involved in cell-cell junction maintenance	IMP IMP: Inferred from mutant phenotype	23202369	GOA
involved in leukocyte cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	17580308	GOA
involved in neutrophil extravasation	IMP IMP: Inferred from mutant phenotype	17580308	GOA
NOT involved in neutrophil migration	IMP IMP: Inferred from mutant phenotype	28240246	GOA
involved in neutrophil migration	IMP IMP: Inferred from mutant phenotype	28807980	GOA
involved in positive regulation of neutrophil degranulation	IGI IGI: Inferred from genetic interaction	21193407	GOA
involved in positive regulation of superoxide anion generation	IGI IGI: Inferred from genetic interaction	21193407	GOA
involved in protein localization to cell surface	IMP IMP: Inferred from mutant phenotype	17244676	GOA
involved in regulation of endocytosis	IDA IDA: Inferred from direct assay	28807980	GOA
involved in regulation of integrin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	28807980	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	12675722	GOA
located in plasma membrane raft	IDA IDA: Inferred from direct assay	21193407	GOA
located in secretory granule membrane	IDA IDA: Inferred from direct assay	18462208	GOA
located in tertiary granule membrane	IDA IDA: Inferred from direct assay	18462208	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
CD177 antigen	NB1 glycoprotein

CD177 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CD177	Q8N6Q3	KCNIP3	Homo sapiens	Q9Y2W7	Validated Y2H	32296183
Intra	CD177	Q8N6Q3	KCNIP3	Homo sapiens	Q9Y2W7	Y2H Prey Pooling	32296183
Intra	CD177	Q8N6Q3	KCNIP3	Homo sapiens	Q9Y2W7	Y2H Array	25416956
Intra	CD177	Q8N6Q3	KCNIP3	Homo sapiens	Q9Y2W7	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD177 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7801	CD177 Protein, Human (HEK293, His)	AAH29167.1 (L22-G407)	≥ 95%, as determined by reducing SDS-PAGE.

CD177 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84674	CD177 Antibody (YA4371)	WB, FC, ELISA	Human
HY-P84674A	CD177 Antibody (YA4371)(PBS only)	WB, FC, ELISA	Human

Related Diseases

Diseases	Alias
Polycythemia	Erythrocythemia Polycythemia Vera Polycythaemia Due To High Altitude
Polycythemia Vera	PV Polycythemia Rubra Vera Prv Osler-Vaquez Disease Chronic Erythremia Polycythaemia Rubra Vera Primary Polycythemia Vaquez Disease Polycythemia Vera, Somatic Osler-Vaquez Syndrome Proliferative Polycythaemia Polycythemia Ruba Vera Acquired Primary Erythrocytosis Heilmeyer-Schoner Disease Vaquez Osler Disease Primary Polycythaemia
Essential Thrombocythemia	Essential Thrombocytosis Familial Thrombocytosis Hemorrhagic Thrombocythemia Hereditary Thrombocythemia Primary Thrombocytosis Idiopathic Thrombocythemia Primary Thrombocythemia Thrombocythemia, Essential Essential Thrombocythaemia Et Familial Thrombocythemia Thrombocythemia Essential
Myelofibrosis	Primary Myelofibrosis Agnogenic Myeloid Metaplasia Idiopathic Myelofibrosis Myeloid Metaplasia Myelofibrosis With Myeloid Metaplasia Osteomyelofibrosis Megakaryocytic Myelosclerosis Myelosclerosis Chronic Idiopathic Myelofibrosis Myelofibrosis, Idiopathic Myelofibrosis With Myeloid Metaplasia, Somatic Myelofibrosis, Somatic Aleukemic Myelosis Bone Marrow Fibrosis MYELOF MMM Agnogenic Myeloid Metaplasia With Myelofibrosis Ammm Myelosclerosis With Myeloid Metaplasia Myelofibrosis Nos
Deep Leiomyoma
Myeloproliferative Neoplasm	Myeloproliferative Disorder Chronic Myeloproliferative Disease Myeloproliferative Neoplasms Chronic Myeloproliferative Disorder Cmpd Cmpd, U Chronic Myeloproliferative Disorders Mpd Mpn Myeloproliferative Disorders Myeloproliferative Disease Campomelic Dysplasia
Neutropenia	Leukopenia
Thrombocytosis	Thrombocythaemia
Myopathy, Centronuclear, 1	Autosomal Dominant Centronuclear Myopathy CNM1 Centronuclear Myopathy 1 Ad-Cnm Myopathy, Centronuclear, Autosomal Dominant Myotubular Myopathy, Autosomal Dominant Centronuclear Myopathy, Autosomal, Modifier Of Autosomal Dominant Myotubular Myopathy Dnm2-Related Centronuclear Myopathy Centronuclear Myopathy Autosomal Dominant Myopathies, Structural, Congenital Myopathy, Centronuclear, Type 1
Leukemia, Chronic Myeloid	Chronic Myeloid Leukemia Chronic Myelogenous Leukemia CML Chronic Granulocytic Leukemia Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib Chronic Myeloid Leukaemia Chronic Granulocytic Leukaemia Chronic Myelogenous Leukaemia Myeloid Leukemia, Chronic Leukemia, Chronic Myelogenous Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic Cml - Chronic Myelogenous Leukemia Cgl Chronic Myelocytic Leukemia Leukemia, Chronic Myeloid, Atypical ACML Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Myeloid Leukemia Chronic Leukemia, Myeloid, Chronic Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Cml- [Chronic Myeloid Leukaemia] Cgl - [Chronic Granulocytic Leukaemia] Chronic Myelocytic Leukaemia
Adult Hepatocellular Carcinoma	Adult Primary Hepatocellular Carcinoma Adult Hepatoma Adult Hcc
Myelodysplastic Syndrome	Myelodysplastic Syndromes Myelodysplasia MDS Myelodysplastic Syndrome Included Myelodysplastic Syndrome, Susceptibility To, Included Myelodysplastic Syndrome, Somatic Myelodysplastic Syndrome, Susceptibility To

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02196	CD177 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17501	Cd177 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23958	Cd177 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CD177	RGD	RGD:1562941
Macaca mulatta	CD177	VGNC	VGNC:70912
Mus musculus	CD177	MGD	MGI:1916141
Canis familiaris	CD177	VGNC	VGNC:38934
Bos taurus	CD177	VGNC	VGNC:27006
Others	CD177	NCBI