Wdr4 - WD repeat domain 4 Gene

Also Known as Wh; mWH; D530049K22Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 57773

Summary

Predicted to contribute to tRNA (guanine-N7-)-methyltransferase activity. Predicted to be involved in tRNA modification. Predicted to act upstream of or within cellular response to DNA damage stimulus and tRNA processing. Predicted to be located in nucleoplasm. Predicted to be part of tRNA methyltransferase complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and thymus. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome. Orthologous to human WDR4 (WD repeat domain 4). [provided by Alliance of Genome Resources, Apr 2022]

Wdr4 Products (6)

mRNA Protein Name
NM_001405110.1 NP_001392039.1 tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform b precursor
NM_001405114.1 NP_001392043.1 tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform c
NM_001405117.1 NP_001392046.1 tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform c
NM_001405119.1 NP_001392048.1 tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform c
NM_001405120.1 NP_001392049.1 tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform c
NM_021322.3 NP_067297.2 tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform a

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
36681682 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4

  • WD repeat-containing protein 4

  • WD40 repeat protein 4

  • protein Wuho homolog

  • tRNA (guanine-N(7)-)-methyltransferase subunit WDR4

Wdr4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Wdr4 Q9EP82 Arhgap17 Mus musculus Q3UIA2
Anti Tag CoIP
36681682
Intra
Wdr4 Q9EP82 Arhgap17 Mus musculus Q3UIA2
Anti Bait CoIP
36681682
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-162080 METTL1-WDR4-IN-1 Inhibitor 99.61% Unkown
HY-162082 METTL1-WDR4-IN-2 Inhibitor 99.14% Unkown
HY-162080A METTL1-WDR4-IN-1 TFA Inhibitor 99.61% Unkown
HY-RS15777 WDR4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22359 Wdr4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28881 Wdr4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Wdr4 NCBI NCBI:10785