STM9005
STM9005 is an orally active and selective inhibitor of the METTL1 tRNA methyltransferase. STM9005 induces differentiation in tumor cells, inhibits cell cycle progression, and downregulates oncoproteins such as MYC and CDK4 across various aggressive tumor cell lines. STM9005 suppresses tumor growth in xenograft models of melanoma, pancreatic ductal adenocarcinoma, and lung cancer, and extends survival in xenograft models of acute myeloid leukemia (AML). STM9005 can be used in research concerning cancers such as melanoma, pancreatic ductal adenocarcinoma, lung cancer, and acute myeloid leukemia.
For research use only. We do not sell to patients.
- CAS No.: 3085023-09-9
- Formula: C21H21Cl2N5O3
- Molecular Weight:462.33
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Biological Activity
Description
IC50 & Target
[1]|
CDK4 |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3085023-09-9
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Molecular Weight 462.33
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Formula C21H21Cl2N5O3
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SMILES
NC1=NC2=CN=CC(N3C[C@@H](OCC3)C(N4[C@H](C5=C(Cl)C=C(Cl)C=C5CC4)C)=O)=C2O1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
STM9005 Related Classifications
HY-190261 Related Classifications
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