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HES4 - hes family bHLH transcription factor 4 Gene

Also Known as bHLHb42

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 57801

About HES4

Cytogenetic location: 1p36.33 Genomic coordinates (GRCh38): 1:998,964-1,000,097 (from NCBI)

This gene has 4 transcripts (splice variants), 171 orthologues and 12 paralogues. Broad expression in fat (RPKM 3.0), prostate (RPKM 2.2) and 19 other tissues.

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anterior/posterior pattern specification and regulation of transcription by RNA polymerase II. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

HES4 Products (3)

mRNA	Protein	Name
NM_001142467.2	NP_001135939.1	transcription factor HES-4 isoform 1
NM_001410700.1	NP_001397629.1	transcription factor HES-4 isoform 3
NM_021170.4	NP_066993.1	transcription factor HES-4 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HES4 Protein Structure

HLH

Hairy_orange

0
100
200
221 a.a.

Protein Preferred Names	Protein Names
transcription factor HES-4	bHLH factor Hes4

Related Diseases

Diseases	Alias
Trichuriasis	Whipworm Infection Whipworm Disease Trichocephaliasis Infection By Trichuris Trichura Trichuriasis Infection Trichuris Trichiura Infection Infection By Trichuris Trichiura Trichocephalosis Infection By Trichocephalus Trichiura Infection By Trichuris Infection By Trichuris Trichiuria Trichuriosis Whipworm Infection Due To Trichuris Trichiura Trichocephalus Infestation Trichuris Infestation Whipworm Infestation
Chromosome 1p36 Deletion Syndrome	1p36 Deletion Syndrome Deletion 1p36 Monosomy 1p36 Subtelomeric 1p36 Deletion Monosomy 1p36 Syndrome Distal Monosomy 1p36 Del(1)(P36) Deletion 1pter Monosomy 1pter

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-180127	UR238	Inhibitor	/	Unkown
HY-P11650	HE4-1 leech peptide	Inhibitor	/	Unkown
HY-RS06137	HES4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown