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ZP4 - zona pellucida glycoprotein 4 Gene

Also Known as ZBP; ZP1; ZPB; ZP1B; ZPB2; Zp-4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 57829

About ZP4

Cytogenetic location: 1q43 Genomic coordinates (GRCh38): 1:237,882,404-237,890,922 (from NCBI)

This gene has 2 transcripts (splice variants), 186 orthologues and 4 paralogues. Low expression observed in reference dataset.

Summary

The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus Furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that Furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for Furin cleavage in this process remains controversial based on mouse studies. Previously, this gene has been referred to as ZP1 or ZPB and thought to have similar functions as mouse Zp1. However, a human gene with higher similarity and chromosomal synteny to mouse Zp1 has been assigned the symbol ZP1 and this gene has been assigned the symbol ZP4. [provided by RefSeq, Jul 2008]

ZP4 Products (1)

mRNA	Protein	Name
NM_021186.5	NP_067009.1	zona pellucida sperm-binding protein 4 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables acrosin binding	IPI IPI: Inferred from physical interaction	15950651	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	26879157	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15950651	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in acrosomal vesicle exocytosis	IMP IMP: Inferred from mutant phenotype	19004505	GOA
involved in negative regulation of binding of sperm to zona pellucida	IDA IDA: Inferred from direct assay	18667750	GOA
involved in positive regulation of T cell proliferation	IDA IDA: Inferred from direct assay	19004505	GOA
involved in positive regulation of acrosome reaction	IDA IDA: Inferred from direct assay	18667750	GOA
involved in positive regulation of humoral immune response	IDA IDA: Inferred from direct assay	19004505	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in egg coat	IDA IDA: Inferred from direct assay	29895852	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZP4 Protein Structure

Trefoil

Zona_pellucida

0
100
200
300
400
500
540 a.a.

Protein Preferred Names	Protein Names
zona pellucida sperm-binding protein 4	zona pellucida protein B

ZP4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ZP4	Q12836	GPX4	Homo sapiens	P36969	Far-WB	23355646
Intra	ZP4	Q12836	ZP4	Homo sapiens	Q12836	EM	26879157
Intra	ZP4	Q12836	ZP4	Homo sapiens	Q12836	IR Spectrometry	26879157
Intra	ZP4	Q12836	GSTM3	Homo sapiens	P21266	Pull Down	23355646
Intra	ZP4	Q12836	GAPDHS	Homo sapiens	O14556	Far-WB	23355646
Intra	ZP4	Q12836	ACR	Homo sapiens	P10323	ELISA	15950651
Intra	ZP4	Q12836	GSTM3	Homo sapiens	P21266	Far-WB	23355646
Intra	ZP4	Q12836	ODF2	Homo sapiens	Q5BJF6-5	Far-WB	23355646
Intra	ZP4	Q12836	ALDOA	Homo sapiens	P04075	Far-WB	23355646
Intra	ZP4	Q12836	ZP4	Homo sapiens	Q12836	X-Ray Diffraction	26879157
Intra	ZP4	Q12836	ENO1	Homo sapiens	P06733	Far-WB	23355646
Intra	ZP4	Q12836	P10323-PRO_0000027518	Homo sapiens	P10323-PRO_0000027518	ELISA	15950651
Intra	ZP4	Q12836	PKM	Homo sapiens	P14618-2	Far-WB	23355646
Intra	ZP4	Q12836	TPI1	Homo sapiens	P60174-1	Far-WB	23355646

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Ovarian Dysgenesis 2	Premature Ovarian Failure 4 ODG2 Ovarian Dysgenesis, Hypergonadotropic, X-Linked Ovarian Failure, Hypergonadotropic, Due To Ovarian Dysgenesis Ovarian Failure Hypergonadotropic Due To Ovarian Dysgenesis X-Linked Hypergonadotropic Ovarian Dysgenesis POF4 Dysgenesis, Ovarian, Type 2
Cataract 1, Multiple Types	Cataract 1 Multiple Types CTRCT1 Cataract 1, Multiple Types, With Or Without Microcornea Czp1 Cae1 Pulverulent Zonular Cataract Cataract, Duffy-Linked Cataract, Zonular Pulverulent, 1 Duffy Linked Cataract Zonular Pulverulent Cataract 1 Cataract Duffy-Linked Cataract-Microcornea Syndrome Cataract Zonular Pulverulent 1 Ccmc Cznp Czp Zonular Nuclear Pulverulent Cataract Cataract, Zonular Pulverulent-1 Zonular Pulverulent Cataract Cataract, Zonular Pulverulent 1 Cataract Microcornea Syndrome
Voyeurism
Usher Syndrome, Type Iiia	Usher Syndrome Type 3 Ush3 Usher Syndrome Type 3a USH3A Usher Syndrome, Type Iii Usher Syndrome, Type 3 Usher Syndrome, Type 3a Usher Syndrome Type Iiia Usher Syndrome 3a Usher'S Syndrome Type 3 Usher Syndrome Iii Usher Syndrome Type Iii
Glaucoma, Primary Open Angle	Glaucoma 1, Open Angle, E Primary Open Angle Glaucoma POAG Adult-Onset Primary Open Angle Glaucoma Chronic Simple Glaucoma GLC1E Primary Open Angle Glaucoma 1e Glaucoma, Open Angle, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16189	ZP4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ZP4	VGNC	VGNC:78985
Rattus norvegicus	ZP4	RGD	RGD:628708
Felis catus	ZP4	VGNC	VGNC:67374
Bos taurus	ZP4	VGNC	VGNC:37367
Canis familiaris	ZP4	VGNC	VGNC:48843