PTX3 - pentraxin 3 Gene

Also Known as TSG-14; TNFAIP5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5806

About PTX3

Cytogenetic location: 3q25.32 Genomic coordinates (GRCh38): 3:157,436,850-157,443,633 (from NCBI)

This gene has 1 transcript (splice variant), 212 orthologues and 5 paralogues. Biased expression in bone marrow (RPKM 32.2), appendix (RPKM 24.8) and 6 other tissues.

Summary

This gene encodes a member of the pentraxin protein family. The expression of this protein is induced by inflammatory cytokines in response to inflammatory stimuli in several mesenchymal and epithelial cell types, particularly endothelial cells and mononuclear phagocytes. The protein promotes fibrocyte differentiation and is involved in regulating inflammation and complement activation. It also plays a role in angiogenesis and tissue remodeling. The protein serves as a biomarker for several inflammatory conditions. [provided by RefSeq, Jun 2016]

PTX3 Products (1)

mRNA	Protein	Name
NM_002852.4	NP_002843.2	pentraxin-related protein PTX3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables complement component C1q complex binding	IDA IDA: Inferred from direct assay	23544079	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	20363749	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19050261	GOA
enables virion binding	IDA IDA: Inferred from direct assay	23544079	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in innate immune response	IDA IDA: Inferred from direct assay	23544079	GOA
involved in negative regulation by host of viral exo-alpha-sialidase activity	IDA IDA: Inferred from direct assay	23544079	GOA
involved in negative regulation by host of viral glycoprotein metabolic process	IDA IDA: Inferred from direct assay	23544079	GOA
involved in negative regulation of exo-alpha-sialidase activity	IDA IDA: Inferred from direct assay	23544079	GOA
involved in negative regulation of glycoprotein metabolic process	IDA IDA: Inferred from direct assay	23544079	GOA
involved in negative regulation of viral entry into host cell	IDA IDA: Inferred from direct assay	23544079	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	23544079	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTX3 Protein Structure

Pentaxin

0
100
200
300
381 a.a.

Protein Preferred Names	Protein Names
pentraxin-related protein PTX3	TNF alpha-induced protein 5

PTX3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PTX3	P26022	FGF2	Homo sapiens	P09038	Solid Phase Assay	20363749
Intra	PTX3	P26022	FGF2	Homo sapiens	P09038	Affinity Chrom	20363749
Intra	PTX3	P26022	FGF2	Homo sapiens	P09038	ELISA	20363749
Intra	PTX3	P26022	O00602-PRO_0000009136	Homo sapiens	O00602-PRO_0000009136	SPR	21490156
Intra	PTX3	P26022	O00602-PRO_0000009136	Homo sapiens	O00602-PRO_0000009136	EM	21490156
Intra	PTX3	P26022	CFH	Homo sapiens	P08603	Solid Phase Assay	19050261
Intra	PTX3	P26022	CFH	Homo sapiens	P08603	Pull Down	19632990
Intra	PTX3	P26022	CFH	Homo sapiens	P08603	ELISA	19050261
Intra	PTX3	P26022	CFH	Homo sapiens	P08603	SPR	19050261
Intra	PTX3	P26022	CFH	Homo sapiens	P08603-2	ELISA	29374201
Intra	PTX3	P26022	FCN1	Homo sapiens	O00602	ELISA	19632990
Intra	PTX3	P26022	FCN2	Homo sapiens	Q15485	SPR	19632990
Intra	PTX3	P26022	FCN2	Homo sapiens	Q15485	ELISA	19632990
Intra	PTX3	P26022	FCN2	Homo sapiens	Q15485	SPR	21490156
Intra	PTX3	P26022	FCN2	Homo sapiens	Q15485	Pull Down	19632990
Intra	PTX3	P26022	FGF2	Homo sapiens	P09038	Crosslink	22267482
Intra	PTX3	P26022	FGF2	Homo sapiens	P09038	Solution Sedimentation	20363749
Intra	PTX3	P26022	FGF2	Homo sapiens	P09038	GMS	20363749

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PTX3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73714	Pentraxin 3/TSG-14 Protein, Human (HEK293, His)	NP_002843.2 (E18-S381, with natural variants A48D)	≥ 95%, as determined by reducing SDS-PAGE.

PTX3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82428	Pentraxin 3 Antibody (YA2173)	WB, FC	Human, Mouse

Related Diseases

Diseases	Alias
Takayasu Arteritis	Aortic Arch Syndrome Pulseless Disease Takayasu'S Arteritis Idiopathic Aortitis Young Female Arteritis Aortic Arch Arteritis Aortic Arches Defect Aortic Arch Defects Takayasu Disease Aortic Arch Syndromes Takayasu'S Disease Ta Obliterative Aortitis Aortic Arch Giant-Cell Arteritis Subclavian-Carotid Obstruction Syndrome Idiopathic Medial Aortopathy And Arteriopathy Takayasu Syndrome Obliterative Brachiocephalic Arteritis Syndrome Raeder-Harbitz Syndrome Chronic Subclavian-Carotid Obstruction Syndrome Giant-Cell Aortitis Takayasu Aortitis Nonspecific Aortoarteritis Sclerosing Aortitis And Arteritis Martorell 2 Syndrome Young Female Aortic Arch Arteritis Syndrome
Aspergillosis	Aspergillosis, Susceptibility To Infection Due To Aspergillus Aspergilloma Aspergillus Nodule Simple Aspergilloma Aspergillus Aspergillus Flavus Infection Aspergillus Fumigatus Infection Aspergillus Infection Infection By Aspergillus Fumigatus Intracavitary Aspergillus Fungus Ball Aspergillus Terreus
Cryptococcosis	Cryptococcus Neoformans Infection Torulosis Busse-Buschke'S Disease Cryptococcal Infection European Cryptococcosis Torula Infection By Cryptococcus Neoformans Cryptococcosis Infection European Blastomycosis European Blastomycotic Infection European Blastomycoses Infection Torula Histolytica Infection
Vasculitis	Angiitis Autoimmune Vasculitis Systemic Vasculitis Vasculitis, Autoimmune
Acute Chest Syndrome	Acute Chest Syndrome In Sickle Cell Disease
Poems Syndrome	Crow-Fukase Syndrome Osteosclerotic Myeloma Polyneuropathy Organomegaly Polyneuropathy, Organomegaly, Endocrinopathy, M Protein, And Skin Changes Syndrome Pep Syndrome Polyneuropathy-Endocrinopathy-Plasma Cell Dyscrasia Syndrome Takatsuki Syndrome
Acute Myocardial Infarction	Cardiac Attack Heart Attack
Coronary Stenosis	Coronary Artery Stenosis
Appendicitis	Acute Appendicitis Acute Appendicitis With Generalized Peritonitis Acute Appendicitis Nos Acute Appendicitis With Peritoneal Abscess Appendiceal Inflammation Appendicitis, Unqualified Acute Appendix Inflammation Acute Appendicitis With Diffuse Peritonitis Following Rupture Or Perforation Acute Appendicitis With Free Peritonitis Acute Appendicitis With Free Perforation To The Abdominal Cavity Perforated Appendix With Generalised Peritonitis Appendicitis With Perforation And Free Pus In The Peritoneal Cavity Perforated Appendix With Localised Peritonitis Acute Appendicitis With Contained Perforation To A Localised Abscess Acute Appendicitis With Localised Peritonitis With Rupture Or Perforation Acute Appendicitis With Localised Peritonitis Without Rupture Or Perforation Acute Appendicitis With Perforation And Contained Peritonitis Into An Abscess Appendicitis With Abscess Appendicitis With Peritoneal Abscess Ruptured Appendix Nos Acute Appendicitis With No Perforation Or Abscess And No Visible Pus Acute Appendicitis With No Specification If Perforated Or Not Acute Appendicitis With Phlegmone
Pre-Eclampsia	Preeclampsia Gestational Hypertension Hypertension Induced By Pregnancy Pre-Eclamptic Toxaemia Pregnancy Associated Hypertension Proteinuric Hypertension Of Pregnancy Hypertension, Pregnancy-Induced, Susceptibility To Preeclampsia/Eclampsia Pregnancy Toxemia Toxaemia Of Pregnancy Gestational Proteinuric Hypertension Pregnancy-Induced Hypertension Toxemia Of Pregnancy Preeclampsia, Susceptibility To Transient Hypertension Of Pregnancy Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria Gestational Hypertension Nos Mild Proteinuric Hypertension Of Pregnancy Pih - [Pregnancy-Induced Hypertension] Pregnancy-Induced Hypertension Nos Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria Pe - [Pre-Eclampsia] Pre-Eclampsia Nos Pre-Eclamptic Nos Pregnancy Pre-Eclampsia Puerperal Pre-Eclampsia Pre-Eclampsia Toxaemia Toxaemia In Pregnancy Pet - [Pre-Eclamptic Toxaemia] Maternal Toxaemia
Erythema Nodosum
Lymphadenitis	Acute Lymphadenitis Chronic Lymphadenitis Adenitis Chronic Adenitis Acute Adenitis Inflammation Of Lymph Node Adenitis Nos Inflammation Of Gland Lymphatic Gland Inflammation Lymph Gland Inflammation Polyadenitis Chronic Adenitis Of Any Lymph Node Except Mesenteric Chronic Lymphadenitis Except Mesenteric Chronic Non-Specific Lymphadenitis
Leptospirosis	Fort Bragg Fever Weil Disease Leptospirosis Icterohaemorrhagica Nanukayami Fever Canicola Fever Hemorrhagic Jaundice Mud Fever Stuttgart Disease Swamp Fever Rat Catcher'S Yellows Spirochetal Jaundice Weil'S Disease Cane-Cutter Fever Icterohemorrhagic Fever Rice-Field Fever Swineherd'S Disease Weil Syndrome Nanukayami Canine Leptospirosis Equine Infectious Anemia Leptospirosis Canicola Fever Due To Leptospira Autumnalis Gikiyami Leptospira Interrogans Autumnalis Infection Leptospira Interrogans Canicola Infection Leptospira Interrogans Hebdomadis Infection Leptospira Interrogans Pomona Infection Nanukayami Disease Pretibial Fever Seven-Day Fever Eia - [Equine Infectious Anaemia] Leptospira Interrogans Infection
Retinal Vein Occlusion	Occlusion, Of Retinal Vein
Orbital Granuloma
Invasive Aspergillosis	Aspergillosis Invasive
Chronic Salpingo-Oophoritis	Chronic Salpingitis And Oophoritis Chronic Salpingitis/Oophoritis
Double Pterygium
Acute Salpingo-Oophoritis	Acute Salpingitis And Oophoritis
Temporal Arteritis	Polymyalgia Rheumatica Giant Cell Arteritis Cranial Arteritis Horton Disease Gca Horton'S Disease Rhizomelic Pseudopolyarthritis Arteritis Cranialis Arteritis Temporalis Horton'S Arteritis Horton'S Giant Cell Arteritis Horton'S Temporal Arteritis Horton'S Syndrome Gca - [Giant Cell Arteritis] Senile Arthritis Polymyalgia Arteritica Pmr - [Polymyalgia Rheumatica] Forestier-Certonciny Syndrome Rheumatic Polymyalgia Polymyalgia
Trichosporonosis
Bacterial Infectious Disease	Bacterial Infections Bacterial Infection Nos Disease Caused By Bacteria Bacterial Disease Or Disorder
Central Nervous System Vasculitis	Vasculitis, Central Nervous System
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Opportunistic Mycosis	Opportunistic Mycoses Opportunistic Systemic Mycoses
Cardiovascular System Disease	Abnormality Of The Cardiovascular System Cardiovascular Disease Disease Of Subdivision Of Hemolymphoid System Disorder Of Cardiovascular System Cardiovascular Diseases
Hemolytic Uremic Syndrome, Atypical 1	Atypical Hemolytic-Uremic Syndrome Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1 Atypical Hemolytic Uremic Syndrome Hemolytic Uremic Syndrome, Atypical, Susceptibility To Ahus AHUS1 Hemolytic-Uremic Syndrome Ahus 1 Ahus, Susceptibility To, 1 Hemolytic Uremic Syndrome, Atypical Non-Shiga-Like Toxin-Associated Hus Non-Stx-Hus Nonenteropathic Hus Atypical Hus Shiga Toxin-Associated Hemolytic Uremic Syndrome D+ Hus Ehec-Hus Hemolytic Uremic Syndrome Associated With Shiga Toxin-Producing Escherichia Coli Hemolytic Uremic Syndrome With Diarrhea Stec-Hus Shiga-Like Toxin-Associated Hus Stx-Hus Typical Hus Typical Hemolytic Uremic Syndrome Atypical Hemolytic Uremic Syndrome With Anti-Factor H Antibodies Atypical Hus With Anti-Factor H Antibodies Ahus With Anti-Factor H Antibodies Ahus With Neutralizing Autoantibodies Against Factor H Hemolytic Uremic Syndrome Atypical 1 Atypical Hemolytic Uremic Syndrome With H Factor Anomaly D Hus Hemolytic-Uremic Syndrome Without Diarrhea Hemolytic-Uremic Syndrome, Atypical, Type 1 Hemolytic Uremic Syndrome, Typical
Preterm Premature Rupture Of The Membranes	Preterm Premature Rupture Of Membranes PPROM Preterm Premature Rupture Of The Membranes, Susceptibility To Pprom - [Preterm Premature Rupture Of Membranes] Preterm Rupture Of Membranes
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Diabetes Mellitus	Diabetes
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10583	PITX3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11457	PTX3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17750	Ptx3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24217	Ptx3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PTX3	MGD	MGI:104641
Macaca mulatta	PTX3	VGNC	VGNC:110346
Bos taurus	PTX3	VGNC	VGNC:33566
Canis familiaris	PTX3	VGNC	VGNC:45204
Rattus norvegicus	PTX3	RGD	RGD:1593476
Felis catus	PTX3	VGNC	VGNC:69185
Others	PTX3	NCBI