CXCL16 - C-X-C motif chemokine ligand 16 Gene

Also Known as SRPSOX; CXCLG16; SR-PSOX

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 58191

About CXCL16

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:4,733,533-4,739,928 (from NCBI)

This gene has 5 transcripts (splice variants) and 88 orthologues. Broad expression in lung (RPKM 40.7), testis (RPKM 23.8) and 24 other tissues.

Summary

Enables chemokine activity. Involved in several processes, including positive regulation of cell growth; response to interferon-gamma; and response to tumor necrosis factor. Located in extracellular space. Biomarker of COVID-19 and systemic scleroderma. [provided by Alliance of Genome Resources, Apr 2022]

CXCL16 Products (2)

mRNA Protein Name
NM_001100812.2 NP_001094282.2 C-X-C motif chemokine 16 isoform 1 precursor
NM_001386809.1 NP_001373738.1 C-X-C motif chemokine 16 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chemokine activity IDA
IDA: Inferred from direct assay
18373975 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of cell growth IMP
IMP: Inferred from mutant phenotype
18373975 GOA
involved in positive regulation of cell migration IMP
IMP: Inferred from mutant phenotype
18373975 GOA
involved in response to cytokine IDA
IDA: Inferred from direct assay
18373975 GOA
involved in response to tumor necrosis factor IDA
IDA: Inferred from direct assay
18373975 GOA
involved in response to type II interferon IDA
IDA: Inferred from direct assay
18373975 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
18373975 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

C-X-C motif chemokine 16

  • CXC chemokine ligand 16

Recombinant CXCL16 Proteins

Cat. No. Product Name Accession Purity
HY-P72961 CXCL16 Protein, Human (HEK293, His) Q9H2A7 (N30-T205)/NP_071342.2 (N49-T224) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P77910 CXCL16 Protein, Human (HEK293, Fc) Q9H2A7 (N30-T205) ≥ 95%, as determined by Bis-Tris PAGE.

CXCL16 Antibodies

Cat. No. Product Name Application Reactivity
HY-P84793 CXCL16 Antibody (YA4490) IHC-P, FC, ELISA Human
HY-P84793A CXCL16 Antibody (YA4490)(PBS only) IHC-P, FC, ELISA Human

Related Diseases

Diseases Alias
Systemic Scleroderma

  • Scleroderma

  • Progressive Systemic Sclerosis

  • Systemic Sclerosis

  • Scleroderma, Systemic

  • Scleroderma Syndrome

  • Dermatosclerosis

  • Familial Progressive Scleroderma

  • Progressive Scleroderma

  • Scleroderma Disease

  • Scleroderma, Localized

  • Diffuse Scleroderma

  • Scleroderma, Familial Progressive
Systemic Lupus Erythematosus

  • Lupus Nephritis

  • SLE

  • Disseminated Lupus Erythematosus

  • Systemic Lupus Erythematosus, Susceptibility To

  • Lupus Erythematosus, Systemic

  • Lupus Nephritis, Susceptibility To

  • Libman-Sacks Disease

  • Systemic Lupus Erythematosus Susceptibility To

  • Sle - Lupus Erythematosus, Systemic

  • Le Syndrome

  • Lupus

  • Lupus Erythematosus Systemic

  • Lupus Erythematosus, Systemic, Susceptibility To

  • Lupus Vulgaris

  • Lupus Erythematosus, Discoid

  • Lupus Erythematosus

  • Systemic Lupus Erythematosus Nos

  • Sle - [Systemic Lupus Erythematosus]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-122197 ML339 Antagonist 99.88% Unkown
HY-133151 CXCR6 antagonist 1 Antagonist / Unkown
HY-RS03389 CXCL16 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16693 Cxcl16 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23128 Cxcl16 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991752 Anti-Mouse CXCL16 Antibody (12-81) Inhibitor 97.425% Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CXCL16 VGNC VGNC:71422
Bos taurus CXCL16 VGNC VGNC:27851
Mus musculus CXCL16 MGD MGI:1932682
Rattus norvegicus CXCL16 RGD RGD:1562928
Felis catus CXCL16 VGNC VGNC:61298
Canis familiaris CXCL16 VGNC VGNC:53326
Others CXCL16 NCBI